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Encyclopedia > H3N2
Flu

H3N2 is a subtype of the species Influenza A virus (sometimes called bird flu virus). H3N2 has mutated into various strains including the Hong Kong Flu strain (now extinct) and the annual flu. Image File history File links Physcian_examining_a_child. ... Influenza, commonly known as the flu or the grippe, is a contagious disease of the upper airways and the lungs, caused by an RNA virus of the orthomyxoviridae family. ... Flu season is mostly a colloquial term used to describe the regular outbreak in flu cases, or even cases of the common cold during the late fall or winter. ... Model of Influenza Virus from NIH The flu vaccine is a vaccine to protect against the highly variable influenza virus. ... This article is about flu treatment in humans for mild human flu, which includes both efforts to reduce symptoms and to battle the flu virus itself. ... This article covers usage of the words used to describe flu in birds. ... H5N1 flu refers to the transmission and infection of H5N1. ... Flu research includes molecular virology, pathogenesis, host immune responses, and epidemiology. ... Influenzavirus A is a genus of a family of viruses called Orthomyxoviridae in virus classification. ... Avian influenza (also known as bird flu) is a type of influenza virulent in birds. ... In biology, mutations are changes to the genetic material (usually DNA or RNA). ...


The annual flu (also called "seasonal flu" or "human flu") kills an estimated 36,000 people in the United States each year. The annual flu vaccine is made by combining vaccines for the new versions of H1N1 and H3N2 viruses that nature produces each year. The dominant strain of annual flu in January 2006 is H3N2. Measured resistance to the standard antiviral drugs amantadine and rimantadine in H3N2 has increased from 1% in 1994 to 12% in 2003 to 91% in 2005. [1] "[C]ontemporary human H3N2 influenza viruses are now endemic in pigs in southern China and can reassort with avian H5N1 viruses in this intermediate host." [2] Flu season is mostly a colloquial term used to describe the regular outbreak in flu cases, or even cases of the common cold during the late fall or winter. ... Human Flu refers to a subset of Orthomyxoviridae that create influenza in humans and are endemic in humans. ... A vaccine is an antigenic preparation used to produce active immunity to a disease, in order to prevent or ameliorate the effects of infection by any natural or wild strain of the organism. ... January 2006 : January - February - March - April - May - June - July - August - September - October - November - December- → 31 January 2006 (Tuesday) U.S. President George W. Bush delivers the State of the Union Address to a joint session of the U.S. Congress (the House of Representatives and the Senate). ... Amantadine, 1-aminoadamantane, is an antiviral drug that was approved by the FDA in 1976 for the treatment of influenza type A in adults. ... Rimantadine (systematic name 1-(1-aminoethyl)adamantane) is an orally administered medicine used to treat, and in rare cases prevent, Influenzavirus A infection. ... 1994 (MCMXCIV) was a common year starting on Saturday of the Gregorian calendar, and was designated the International year of the Family. ... 2003 (MMIII) was a common year starting on Wednesday of the Gregorian calendar. ... 2005 (MMV) was a common year starting on Saturday of the Gregorian calendar. ...

Contents


Hong Kong Flu

The Hong Kong Flu strain of H3N2 evolved from H2N2 by antigenic shift and caused the Hong Kong Flu pandemic of 1968 and 1969 that killed up to 750,000. [3] "An early-onset, severe form of influenza A (H3N2) made headlines when it claimed the lives of several children in the United States in late 2003." [4] Antigenic shift is the process by which two different strains of influenza combine to form a new subtype having a mixture of the surface antigens of the two original strains. ... The Hong Kong Flu was a pandemic outbreak of influenza that began in Hong Kong in 1968 and spread to the United States of America that year. ... 2003 (MMIII) was a common year starting on Wednesday of the Gregorian calendar. ...


Both the H2N2 and H3N2 pandemic strains contained Avian flu virus RNA segments. "While the pandemic human influenza viruses of 1957 (H2N2) and 1968 (H3N2) clearly arose through reassortment between human and avian viruses, the influenza virus causing the 'Spanish flu' in 1918 appears to be entirely derived from an avian source (Belshe 2005)." [5] This article covers usage of the words used to describe flu in birds. ...


The Hong Kong Flu was a pandemic outbreak of influenza that began in Hong Kong in 1968 and spread to the United States of America that year. The outbreak ended the following year, in 1969. A pandemic (from Greek pan all + demos people) is an epidemic (an outbreak of an infectious disease) that spreads worldwide, or at least across a large region. ... Influenza, commonly known as the flu or the grippe, is a contagious disease of the upper airways and the lungs, caused by an RNA virus of the orthomyxoviridae family. ... 1968 (MCMLXVIII) was a leap year starting on Monday (the link is to a full 1968 calendar). ... 1969 (MCMLXIX) was a common year starting on Wednesday (the link is to a full 1969 calendar). ...


The Hong Kong flu was the first known outbreak of the H3N2 strain.


Because of its similarity to the 1957 Asian Flu (which was the H2N2 strain, differing from the Hong Kong flu only in the chemical arrangement of the hemagglutinin protein as a result of antigenic shift) and possibly the subsequent accumulation of related antibodies in the affected population, the Hong Kong flu resulted in much fewer casualties than most pandemics. Casualty estimates vary: between 750,000 and two million people died of the virus worldwide (34,000 people in the United States) during the two years (1968-1969) that it was active. It was therefore the least lethal pandemic in the 20th century. 1957 (MCMLVII) was a common year starting on Tuesday of the Gregorian calendar. ... The Avian Flu was a pandemic outbreak of influenza that originated in China in 1957 and spread worldwide that same year. ... The Asian Flu was a pandemic outbreak of influenza that originated in China in 1957 and spread worldwide that same year. ... Antigenic shift is the process by which two different strains of influenza combine to form a new subtype having a mixture of the surface antigens of the two original strains. ... Schematic of antibody binding to an antigen An antibody is a protein used by the immune system to identify and neutralize foreign objects like bacteria and viruses. ... (19th century - 20th century - 21st century - more centuries) Decades: 1900s 1910s 1920s 1930s 1940s 1950s 1960s 1970s 1980s 1990s As a means of recording the passage of time, the 20th century was that century which lasted from 1901–2000 in the sense of the Gregorian calendar (1900–1999 in the...


Conspiracy Theories

It has been alleged that the Hong Kong Flu was released in the United States as part of a Soviet germ-warfare plot.


Further reading

The Influenza Genome Sequencing Project is funded by the National Institute of Allergy and Infectious Diseases (NIAID) which is a component of the National Institutes of Health (NIH), which is an agency of the United States Department of Health and Human Services. ...

Sources

  1. ^ Reason New York Times
  2. ^ NAP online book
  3. ^ (Detailed chart of its evolution here.)
  4. ^ NAP online book
  5. ^ Chapter Two : Avian Influenza by Timm C. Harder and Ortrud Werner from excellent free on-line Book called Influenza Report 2006 which is a medical textbook that provides a comprehensive overview of epidemic and pandemic influenza.

New Scientist: Bird Flu


  Results from FactBites:
 
Animal Health - Swine Influenza, H3N2 (2086 words)
Two antigenically distinct reassortant viruses (H3N2) were isolated from infected animals: a double-reassortant virus containing genes similar to those of human and swine viruses, and a triple-reassortant virus containing genes similar to those of human, swine, and avian influenza viruses.
Because the U.S. pig population was essentially naive in regard to H3N2 viruses, it was important to determine the extent of viral spread.
H3N2 influenza viruses recovered from Quebec swine in 1990 have previously been shown to be similar to earlier 1975 human strains, suggesting that pigs act as a reservoir for human influenza virus.
Influenza A (H3N2) Outbreak, Nepal | CDC EID (3119 words)
In July 2004, an outbreak of influenza A (H3N2) was detected at 3 Bhutanese refugee camps in southeastern Nepal.
H3N2 viruses continue to drift from the vaccine strain and may remain as the dominant strains during the 2005–2006 influenza season.
The phylogeny of H3N2 HA proteins indicates a drifting of the Nepal isolates from the A/Fujian/411/03 and A/Wyoming/03/03 vaccine strains and shows that these outbreak isolates have a higher genetic homology to A/Wellington/1/04, a prototype strain selected as the 2005–2006 Southern Hemisphere H3 vaccine strain (Figure 2).
  More results at FactBites »


 
 

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