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Encyclopedia > Hashimoto's thyroiditis
Hashimoto's thyroiditis
Classification & external resources
Histology
ICD-10 E06.3
ICD-9 245.2
OMIM 140300
DiseasesDB 5649
eMedicine med/949 
MeSH D050031

Hashimoto's thyroiditis or chronic lymphocytic thyroiditis is an autoimmune disease where the body's own antibodies attack the cells of the thyroid. Image File history File linksMetadata No higher resolution available. ... The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ... The International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) is a coding of diseases and signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or diseases, as classified by the World Health Organization (WHO). ... // E00-E35 - Endocrine diseases (E00-E07) Disorders of thyroid gland (E00) Congenital iodine-deficiency syndrome (E01) Iodine-deficiency-related thyroid disorders and allied conditions (E02) Subclinical iodine-deficiency hypothyroidism (E03) Other hypothyroidism (E030) Congenital hypothyroidism with diffuse goitre (E031) Congenital hypothyroidism without goitre (E032) Hypothyroidism due to medicaments and other... The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ... The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The Disease Bold textDatabase is a free website that provides information about the relationships between medical conditions, symptoms, and medications. ... eMedicine is an online clinical medical knowledge base that was founded in 1996. ... Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ... Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. ... Each antibody binds to a specific antigen; an interaction similar to a lock and key. ... Drawing of the structure of cork as it appeared under the microscope to Robert Hooke from Micrographia which is the origin of the word cell. Cells in culture, stained for keratin (red) and DNA (green). ...


This disorder is believed to be the most common cause of primary hypothyroidism in North America. It occurs far more often in women than in men (10:1 to 20:1), and is most prevalent between 45 and 65 years of age. North America North America is a continent[1] in the Earths northern hemisphere and (chiefly) western hemisphere. ...


In European countries an atrophic form of autoimmune thyroiditis (Ord's thyroiditis) is more common than Hashimoto's thyroiditis. Atrophy is the partial or complete wasting away of a part of the body. ... Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. ... Thyroiditis is an inflammation of the thyroid gland. ...

Contents

Causes

A family history of thyroid disorders is common, with the HLA-DR5 gene most strongly implicated conferring a relative risk of 3 in the UK. HLA-DR antigens are a group of antigens in the Class II/HLA-D family which can be used as indicators of several different diseases (per MeSH): HLA-DR1 Antigen - unknown HLA-DR2 Antigen - Goodpasture syndrome, multiple sclerosis, and narcolepsy HLA-DR3 Antigen - celiac disease, Graves disease, dermatitis herpetiformis... In statistics and mathematical epidemiology, relative risk (RR) of an event associated with the exposure is a ratio of probability of outcome of interest in exposed group versus treatment group. ...


The genes implicated vary in different ethnic groups and the incidence is increased in patients with chromosomal disorders, including Turner's, Down, and Klinefelter's syndromes. Turner syndrome or Ullrich-Turner syndrome encompasses several chromosomal abnormalities, of which monosomy X is the most common. ... Down syndrome or trisomy 21 (usually Downs Syndrome in British English[1]) is a genetic disorder caused by the presence of all or part of an extra 21st chromosome. ... Not to be confused with XYY syndrome or XXX syndrome. ...


The underlying specifics of the immune system destruction of thyroid cells is not clearly understood. Various autoantibodies may be present against thyroid peroxidase, thyroglobulin and TSH receptors, although a small percentage of patients may have none of these antibodies present. A percentage of the population may also have these antibodies without developing Hashimoto's thyroiditis.


Presentation

In many cases, Hashimoto's thyroiditis usually results in hypothyroidism, although in its acute phase, it can cause a transient thyrotoxic state. This article or section does not cite its references or sources. ... Hyperthyroidism (or overactive thyroid gland) is the clinical syndrome caused by an excess of circulating free thyroxine (T4) or free triiodothyronine (T3), or both. ...


Physiologically, antibodies against thyroid peroxidase and/or thyroglobulin cause gradual destruction of follicles in the thyroid gland. Accordingly, the disease can be detected clinically by looking for these antibodies in the blood. It is also characterised by invasion of the thyroid tissue by leukocytes, mainly T-lymphocytes. It is associated with non-Hodgkin lymphoma. Each antibody binds to a specific antigen; an interaction similar to a lock and key. ... Thyroid peroxidase is an enzyme (EC 1. ... Thyroglobulin is a protein secreted by the thyroid gland. ... In botany, a follicle is a type of simple dry fruit produced by certain flowering plants. ... White Blood Cells is also the name of a White Stripes album. ... T cells belong to a group of white blood cells known as lymphocytes and play a central role in cell-mediated immunity. ... Non-Hodgkin lymphoma is a cancer arising from lymphocytes, a type of white blood cells. ...


Symptoms of Hashimoto's thyroiditis include symptoms of hypothyroidism and a goitre. This article or section does not cite its references or sources. ... A goitre (or goiter) (Latin struma), also called a bronchocele, is a swelling in the neck (just below Adams apple or larynx) due to an enlarged thyroid gland. ...


Treatment

Treatment is with daily thyroxine, with the sodium salt of thyroxine liothyronine given when the need to raise levels of circulating thyroxine is urgent. Thyroxine, or 3:5,3:5 tetra­iodothyronine (often abbreviated as T4) is the major hormone secreted by the follicular cells of the thyroid gland. ...


Eponym

Hashimoto Dori in Kyushu uni.
Hashimoto Dori in Kyushu uni.

Also known as Hashimoto's disease, Hashimoto's thyroiditis is named after the Japanese physician Hashimoto Hakaru (1881−1934) of the medical school at Kyushu University,[1] who first described the symptoms in 1912 in a German publication[2]. Image File history File links Size of this preview: 800 × 533 pixelsFull resolution (1536 × 1024 pixel, file size: 303 KB, MIME type: image/jpeg) Ich machte dieses Foto von mir in 2006. ... Image File history File links Size of this preview: 800 × 533 pixelsFull resolution (1536 × 1024 pixel, file size: 303 KB, MIME type: image/jpeg) Ich machte dieses Foto von mir in 2006. ... New Hospital bldg Campus of Maidashi area in prior to Greater East Asia War (This picture exists in Department of Medicine attachment library ) Kyushu University ), abbreviated to Kyudai ), is one of Japans most prestigious national universities and the largest public university on the island of KyÅ«shÅ«. It is... Hashimotos thyroiditis is the most common form of thyroiditis, an autoimmune disease where the bodys own antibodies fight the cells of the thyroid. ... Hashimoto Dori in Kyushu uni. ... New Hospital bldg Campus of Maidashi area in prior to Greater East Asia War (This picture exists in Department of Medicine attachment library ) Kyushu University ), abbreviated to Kyudai ), is one of Japans most prestigious national universities and the largest public university on the island of KyÅ«shÅ«. It is...


Noted sufferers

Vickie Lynn Marshall (November 28, 1967 – February 8, 2007), better known under the stage name of Anna Nicole Smith,[1] was an American model, actress and celebrity. ...

References

  1. ^ Hakaru Hashimoto at Who Named It
  2. ^ H. Hashimoto: Zur Kenntnis der lymphomatösen Veränderung der Schilddrüse (Struma lymphomatosa). Archiv für klinische Chirurgie, Berlin, 1912, 97: 219−248.
  3. ^ The Smoking Gun

Who Named It is a Norwegian database of several thousand eponymous medical signs and the doctors associated with their identification. ...

External links



 

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