Hemagglutination (also haemagglutination) is a more specific form of agglutination that involves red blood cells. It has two common uses in the laboratory: blood typing and the quantification of virus dilutions. agglutination ...
Blood Typing
Using antibodies that bind to the A or B blood group in a sample of blood, one can determine the blood type of the individual being tested.
For example, if antibodies that bound to the A blood group were added and agglutination occurred, it could be concluded that the blood was either type A or type AB. Then if antibodies that bound the B group were added and agglutination did not occur, it could be concluded that the blood was type A.
In blood grouping the patient's serum is tested against RBCs of known blood groups and also the patient's RBCs are tested against known serum types. In this way the patient's blood group is confirmed from both RBCs and serum. A direct Coombs test is also done on the patient's blood sample in case there are any confounding antibodies.
The nonspecific hemagglutination inhibitors and natural hemagglutinins in a test serum for a virus hemagglutination-inhibition reaction can be removed at one stroke in a convenient procedure by pretreating the test serum with a composition containing both fixed avian erythrocytes and kaolin particles.
The common procedure heretofore taken for this purpose is a two-step procedure which comprises adding kaolin particles to the test serum, incubating the mixture to adsorb and remove the nonspecific hemagglutination inhibitors, centrifuging the same and incubating the supernatant with erythrocytes to cause neutral agglutinins to be adsorbed on the erythrocytes.
By this pretreatment with the composition of the present invention, both nonspecific hemagglutination inhibitors and natural hemagglutinins in a test serum can be removed at one stroke but the activity of a virus-specific HI antibody occurring in the same serum is not adversely affected.
Hemagglutination slide test for the qualitative and quantitative detection of infectious mononucleosis heterophile antibodies in serum or plasma.
Hemagglutination slide test for the differential qualitative detection and quantitative determination of infectious mononucleosis and other heterophile antibodies in serum or plasma.
Hemagglutination slide test for the qualitative detection and quantitative determination of antibodies to streptococcal extracellular antigens in serum, plasma, or whole blood.
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