|
Amine Reactivity (2694 words) |
 | The tendency of Hofmann eliminations to give the less-substituted double bond isomer is commonly referred to as the Hofmann Rule, and contrasts strikingly with the Zaitsev Rule formulated for dehydrohalogenations and dehydrations. |
| To understand why the base-induced elimination of 4º-ammonium salts behaves differently from that of alkyl halides it is necessary to reexamine the nature of the E2 transition state, first described for dehydrohalogenation. |
| An elimination reaction, complementary to the Hofmann elimination, occurs when 3º-amine oxides, prepared by oxidizing 3º-amines with peroxides, are heated at temperatures of 150 to 200 ºC. This reaction is known as the Cope Elimination. |
Feeds |
Contact