While the undershoot of an action potential is called a hyperpolarization, this definition is too narrow. More broadly, the hyperpolarization of a biological cell means any change in trans-membrane voltage that is more polarized. Thus, hyperpolarizations can be in either the positive or negative direction. In the scientific vernacular however, a hyperpolarization is generally used (technically incorrectly) to describe any movement of membrane potential in a direction that makes it less positive or more negative. (See the article depolarization for a more complete explanation of the (mis)use of this nomenclature).
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A voltage-clamp study of the currents that are activated by membranehyperpolarization of MNV neurones is lacking, and thus the identity of the channels that underlie anomalous inward rectification in these neurones is unknown.
This hyperpolarization was not sustained and decayed during the pulse (Fig.
The injection of hyperpolarizing current (top) caused a change in the membrane potential (bottom) which was followed by a sag in the membrane voltage response (indicated by arrowhead in the left trace).
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