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Encyclopedia > Hypertriglyceridaemia

In medicine, hypertriglyceridemia denotes high (hyper-) blood levels (-emia) of triglycerides, the most abundant fatty molecule in most organisms. It has been associated with atherosclerosis, even in the absence of hypercholesterolemia (high cholesterol levels). It can also lead to pancreatitis in excessive concentrations. Very high triglyceride levels may also interfere with blood tests; hyponatremia may be reported spuriously (pseudohyponatremia).


Causes include:

Treatment of hypertriglyceridemia is by fat restriction in the diet, as well as with fibrates and statins (two classes of drugs). High doses of fish oils containing omega-3 fatty acids may help.


  Results from FactBites:
 
Lipid Abnormalities Associated with ART May Be Different Than That Associated with Risk for Cardiovascular Disease in ... (2660 words)
Familial combined hyperlipidaemia is caused by overproduction of small VLDL particles in the liver, leading to a parallel increase in apolipoprotein B and is associated with increased cardiovascular risk.
Hypertriglyceridaemia was associated with stavudine and abacavir treatment in a univariate analysis, but no variable survived in the multivariate model.
Patients with familial hypertriglyceridaemia show a normal number of large triglyceride-rich VLDL particles, resulting in a high ratio of VLDL-triglycerides to VLDL-apolipoprotein B. Patients with familial combined hyperlipidaemia, where the number of normally sized particles is increased, are characterized by a low ratio.
MEDLINE_1996-2006 - Results of the search <page 1> (338 words)
Hypertriglyceridaemia is thought to be the aetiology in 3% of patients with acute pancreatitis, often associated with poorly controlled diabetes mellitus or chronic alcohol abuse.
In 2 patients hypertriglyceridaemia was associated with diabetes mellitus, in one patient with pregnancy and in another with chronic alcohol abuse.
Hypertriglyceridaemia is a common and under-diagnosed etiology of acute non-biliary pancreatitis.
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