| Progress in Transplantation: Treating gout in kidney transplant recipients (1108 words) |
 | Hyperuricemia is defined as serum urate concentrations greater than 416 µml/L (7 mg/dL) with no symptoms of uric acid deposits.4 Uric acid is the end product of purine metabolism and is filtered in the glomeruli before being reabsorbed in the proximal tubule, where it is then excreted distally into the urine. |
| Gout is defined as hyperuricemia of intra-articular monosodium urate crystals with symptomatic occurrences including inflammation at joints, erythema, and decreased range of motion often associated with severe pain or discomfort.4,7 Following initial gout attacks, patients are susceptible to future acute flares unless the underlying cause is remedied and risks factors are modified. |
| Hyperuricemia is a common manifestation in patients with renal dysfunction, as uric acid tends to accumulate. |
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