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Encyclopedia > Hypoxanthine

Hypoxanthine is a naturally occurring purine derivative, and one of the products of the action of xanthine oxidase on xanthine, though more normally in purine degradation, hypoxanthine is oxidized by xanthine oxidase to form xanthine. It is very occasionally found as a constituent of nucleic acids where it is present in the anticodon of tRNA in the form of its nucleotide inosine.


Image:hypoxanthine.jpg


  Results from FactBites:
 
lesch-nyhan03.html (2249 words)
Plasma and 24-h urinary concentrations of hypoxanthine, xanthine and uric acid were measured while subjects were on a purine-restricted diet.
The sensitivity of 24-h urinary hypoxanthine and xanthine excretion rates was 86% and 77%, respectively, and the specificity 100% for both tests.
An elevated hypoxanthine and/or xanthine excretion rate differentiated most heterozygotes for HPRT deficiency from non-carrier women and thus could be useful for carrier diagnosis.
Fetal Plasma Hypoxanthine Level in Growth-Retarded Fetuses Before Labor -- Sawa et al. 82 (12): 4028 -- Journal of ... (2419 words)
Hypoxanthine is one of the purine nucleotides and is presumed
hypoxanthine is correlated with fetal hypoxia and acidosis in
HYPOXANTHINE is one of the intermediates in the degradation
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