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Sensitization of hypoxic tumor cells and control of growth thereof - Patent 4889525 (9951 words) |
 | Method of sensitizing hypoxic tumor cells to radiotherapy and chemotherapy by contacting the cells or the vasculature thereof with an aqueous dispersion of an oxygen carrying perfluoro compound and a dispersant for the compound, and sensitizing chemotherapeutic and protective compositions therefor. |
| A method of controlling the growth of hypoxic tumor cells which comprises (a) sensitizing the cells to chemotherapy by contacting the cells with an aqueous dispersion of any oxygen carrying perfluoro compound and a dispersant for the perfluoro compound, and (b) contacting the cells with a chemotherapeutic agent whose efficacy is oxygen dependent. |
| In accordance with the present invention effective sensitization of hypoxic tumor cells, as a prelude to highly beneficial radiotherapy and/or oxygen-dependent chemotherapy, is achieved by contacting the cells or vasculature thereof with an oxygen carrying perfluoro compound, wherein the perfluoro compound is uniformly dispersed in small particle size in an aqueous medium. |
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PRINCIPLES OF RADIATION ONCOLOGY(Jan.1997) (4402 words) |
| Radiotherapeutic tumor control is achieved by the elimination of all viable cells within a tumor, and a given dose of radiation will result in the death of a certain proportion (not number) of viable cells with each administration. |
| The sigmoidal shape of the curve is a result of the heterogeneity among the tumor cell population for a given neoplasm with regard to the number of viable tumor cells and the proportion of cells that are hypoxic. |
| The concept is based on the notion that tumor cell killing by radiation is an exponential function of dose and that the dose required for a particular tumor control probability is proportional to the logarithm of the number of viable cells in the tumor. |
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