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In May 1931, at age seventeen, Zel'dovich became a laboratory assistant at the Institute of Chemical Physics of the USSR Academy of Sciences.
In 1977 Zel'dovich together with F. Shapiro was awarded the Kurchatov Medal, the highest award in nuclear physics of the USSR.
Zel'dovich worked on the theory of evolution of the hot universe, on the properties of microwave background radiation, on the large-scale structure of the universe, and on the theory of fl holes.