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Encyclopedia > Immunoglobulin G
Molecular surface of an IgG molecule
Molecular surface of an IgG molecule

Immunoglobulin G(IgG) is a monomeric immunoglobulin, built of two heavy chains γ and two light chains. Each molecule has two antigen binding sites. This is the most abundant immunoglobulin and is approximately equally distributed in blood and in tissue liquids, constituting 75% of serum immunoglobulins in humans.[1] Download high resolution version (960x768, 176 KB) Wikipedia does not have an article with this exact name. ... Download high resolution version (960x768, 176 KB) Wikipedia does not have an article with this exact name. ... Schematic of antibody binding to an antigen An antibody is a protein complex used by the immune system to identify and neutralize foreign objects like bacteria and viruses. ... Each antibody binds to a specific antigen; an interaction similar to a lock and key. ... Each antibody binds to a specific antigen; an interaction similar to a lock and key. ... An antigen is a molecule that stimulates an immune response. ... Human blood smear: a - erythrocytes; b - neutrophil; c - eosinophil; d - lymphocyte. ... Blood plasma is the liquid component of blood, in which the blood cells are suspended. ...

Contents

Functions

This is the only isotype that can pass through the human placenta (except for IgG2[2]), thereby providing protection to the fetus in its first weeks of life before its own immune system has developed. Isotype - the International System of Typographic Picture Education - was developed by the Austrian educator and philosopher Otto Neurath, along with the illustrator Gerd Arntz. ... The placenta is an ephemeral (temporary) organ present in female placental vertebrates during gestation (pregnancy), but a placenta has evolved independently also in other animals as well, for instance scorpions and velvet worms. ... Human fetus at eight weeks. ... A scanning electron microscope image of a single neutrophil (yellow), engulfing anthrax bacteria (orange). ...


It can bind to many kinds of pathogens, for example viruses, bacteria, and fungi, and protects the body against them by complement activation (classic pathway), opsonization for phagocytosis and neutralisation of their toxins. A pathogen or infectious agent is a biological agent that causes disease or illness to its host. ... Groups I: dsDNA viruses II: ssDNA viruses III: dsRNA viruses IV: (+)ssRNA viruses V: (-)ssRNA viruses VI: ssRNA-RT viruses VII: dsDNA-RT viruses A virus (from the Latin noun virus, meaning toxin or poison) is a microscopic particle (ranging in size from 20 - 300 nm) that can infect the... Phyla Actinobacteria Aquificae Chlamydiae Bacteroidetes/Chlorobi Chloroflexi Chrysiogenetes Cyanobacteria Deferribacteres Deinococcus-Thermus Dictyoglomi Fibrobacteres/Acidobacteria Firmicutes Fusobacteria Gemmatimonadetes Lentisphaerae Nitrospirae Planctomycetes Proteobacteria Spirochaetes Thermodesulfobacteria Thermomicrobia Thermotogae Verrucomicrobia Bacteria (singular: bacterium) are unicellular microorganisms. ... Divisions Chytridiomycota Zygomycota Ascomycota Basidiomycota The Fungi (singular: fungus) are a large group of organisms ranked as a kingdom within the Domain Eukaryota. ... A complement protein attacking an invader. ... An opsonin is any molecule that acts as a binding enhancer for the process of phagocytosis. ... Phagocytosis is a form of endocytosis wherein large particles are enveloped by the cell membrane of a (usually larger) cell and internalized to form a phagosome, or food vacuole. ... Neutralisation (or neutralization) in the immunological sense refers to the ability of antibodies to block the site(s) on bacteria or viruses that they use to enter their target cell. ...


Delayed-onset food allergy, igG.


Subclasses

Name Percent Crosses placenta easily Complement activator Binds to Fc receptors on phagocytic cells
IgG1 66% yes second highest high affinity
IgG2 23% no third highest extremely low affinity
IgG3 7% yes highest high affinity
IgG4 4% yes no intermediate affinity

The placenta is an ephemeral (temporary) organ present in female placental vertebrates during gestation (pregnancy), but a placenta has evolved independently also in other animals as well, for instance scorpions and velvet worms. ... An antibody digested by papain yields two fragments, two Fab fragments and one Fc fragment Schematic diagram showing Fc receptor interaction with an antibody-coated microbial pathogen The fragment crystallizable region (Fc region) is a region of an antibody composed of two heavy chains that each contribute three or four...

See also

Each antibody binds to a specific antigen; an interaction similar to a lock and key. ...

External links

References

  1. ^ Junqueira, Luiz C.; Jose Carneiro (2003). Basic Histology. McGraw-Hill. ISBN 0838505902. 
  2. ^ Immunology at MCG 3/biologic

 

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