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Encyclopedia > Inhibitory postsynaptic potential

Inhibitory Postsynaptic Potential is commonly abbreviated to IPSP. Impulses are transmitted from neuron to neuron by the release of a chemical transmitter across synaptic clefts from the synaptic vesicles along the axon to the postsynaptic receptors of another neuron. An EPSP has the effect of depolarizing--driving the charge to positive--a neuron and the IPSP has the effect of hyperpolarizing--driving the charge farther negative--it. In general, having more positive ions (or less negative ones) inside the cell will increase the chance (and thus, rate) of action potential firing. Conversely, driving a cell to negativity will usually lower the firing rate. Drawing by Santiago Ramón y Cajal of cells in the pigeon cerebellum. ... Illustration of the major elements in a prototypical synapse. ... An axon, or nerve fibre, is a long slender projection of a nerve cell, or neuron, which conducts electrical impulses away from the neurons cell body or soma. ... Excitatory Postsynaptic Potential is generally abbreviated to Much information is available under the heading synapse, but this is a different concept. ... A. A schematic view of an idealized action potential illustrates its various phases as the action potential passes a point on a cell membrane. ...


Ionic Basis of IPSP

In case of inhibitory synapse the post synaptic neural membrane permiability is increased only to positive potassium ions & negative chloride ions but not sodium ions, causing on influx of chloride ions and efflux of K+, thereby decrease the charge of the resting neuronal potential. This is called hyperpolarised state.


In addition IPSP may produced by closure of sodium or calssium channels.


Currently there is more information available under the heading synapse. Illustration of the major elements in a prototypical synapse. ...


References

Also see:


  Results from FactBites:
 
Dopamine Activates Two Different Receptors to Produce Variability in Sign at an Identified Synapse -- Magoski and ... (6275 words)
reversal potentials of the IPSP and the inhibitory dopamine response
VD4 IPSP and the VD4 inhibitory pressure-applied dopamine response.
As the postsynaptic membrane potential was increased, the IPSP decreased.
Inhibitory postsynaptic potential - Wikipedia, the free encyclopedia (198 words)
An Inhibitory Postsynaptic Potential (commonly abbreviated as IPSP) is the change in membrane voltage of a postsynaptic neuron which results from synaptic activation of inhibitory neurotransmitter receptors.
A postsynaptic potential is considered inhibitory, when the resulting change in membrane voltage makes it more difficult for the cell to fire an action potential, lowering the firing rate of the neuron.
They are the opposite of excitatory postsynaptic potentials (EPSPs), which result from the flow of positive ions into the cell.
  More results at FactBites »


 

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