Isabella Clark (-1857) was the first wife of Sir John A. Macdonald, first Prime Minister of Canada. She was his second-cousin; they had a maternalgrandmother in common. She became ill after just two years marriage in 1845 and died of unknown causes after 13 years of misfortunate marriage, set mostly in sickrooms. They had two sons: John and Hugh, the former died at 13 months. She had also developed an addiction to opium mixed with wine.
Isabella supervised the servants, making sure that the house was kept clean, the laundry done, and that dinner was ready for John when he got home at night on the days when he was in town.
Isabella lived to celebrate Hugh's 7th birthday then was finally taken by her long illness three days after Christmas of 1857.
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