Jacques Francis Albert Pierre Miller is a distinguished research scientist. He is famous for having discovered the function of the thymus and for the identification, in mammalian species of the two major subsets of lymphocytes (T cells and B cells) and their function. In human anatomy, the thymus is a ductless gland located in the upper anterior portion of the chest cavity. ... A lymphocyte is a type of white blood cell involved in the human bodys immune system. ... T cells are a subset of lymphocytes that play a large role in the immune response. ... B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell-mediated immune response). ...

Jacques F.A.P. Miller

Miller was born on April 2, 1931, in Nice, France, as J.F.A.P. Meunier, and grew up in France, Switzerland and China, mostly in Shanghai. After the outbreak of World War II and Japan's entry into the war, his family moved in 1941 to Sydney, Australia, and changed their last name to “Miller”. Image File history File links File history Legend: (cur) = this is the current file, (del) = delete this old version, (rev) = revert to this old version. ... 2 April is the 92nd day of the year (93rd in leap years) in the Gregorian calendar, with 273 days remaining. ... 1931 (MCMXXXI) is a common year starting on Thursday. ... City motto: Nicæa civitas. ... Shanghai (Chinese: 上海 pinyin: â–¶ (help· info); Shanghainese IPA: ; Lumazi: Zanhe) , situated on the banks of the Yangtze River Delta, is Chinas largest city. ... Combatants Allied Powers Axis Powers Commanders {{{commander1}}} {{{commander2}}} Strength {{{strength1}}} {{{strength2}}} Casualties 17 million military deaths 7 million military deaths World War II, also known as the Second World War (sometimes WW2 or WWII), was a mid-20th century conflict that engulfed much of the globe and is accepted as... Sydney, the Emerald City or the Harbour City, is the state capital and most populous city of the Australian state of New South Wales, as well as Australias largest and oldest city (founded in 1788). ...

Following a distinguished undergraduate career in medicine at the University of Sydney, Miller began in the early 1960s his PhD studies at the Chester Beatty Research Institute in South Kensington, London, where he investigated the pathogenesis of lymphocytic leukaemia in mice and the role of the thymus in that disease. This was at a time when the thymus was believed to be a vestigial organ with no function. Miller discovered that the thymus is vital for development and function of the adaptive immune system, by showing that experimental animals without a thymus at birth were incapable of rejecting foreign tissues and resisting many infections. The University of Sydney The University of Sydney, established in 1850, is the oldest university in Australia, and it is located in Sydney, the capital city of the state of New South Wales. ... London is the capital city of the United Kingdom and of England. ... Leukemia (leukaemia in Commonwealth English) is a group of blood diseases characterized by malignancies (cancer) of the blood-forming tissues. ... In human anatomy, the thymus is a ductless gland located in the upper anterior portion of the chest cavity. ... In human anatomy, the thymus is a ductless gland located in the upper anterior portion of the chest cavity. ... In human anatomy, the thymus is a ductless gland located in the upper anterior portion of the chest cavity. ... In human anatomy, the thymus is a ductless gland located in the upper anterior portion of the chest cavity. ...

In 1966, Miller returned to Australia to become a research group leader at The Walter and Eliza Hall Institute of Medical Research (WEHI) in Melbourne, at the invitation of its new director Sir Gustav Nossal, the successor of Sir Macfarlane Burnet. There, he discovered that mammalian lymphocytes can be separated into T cells and B cells, and that these interact to allow normal antibody production (T cell help). His work also showed that the thymus produces the T cells, that it removes autoreactive T cells (central T cell tolerance) and several other landmark findings in immunology. These are considered crucial to understanding diseases such as cancer, autoimmunity and AIDS, as well as processes such as transplant rejection, allergy and antiviral immunity. Miller is semi-retired since 1996 and still works several days each week at the WEHI. The Walter and Eliza Hall Institue of Medical Research is located in Parkville, Melbourne. ... Melbourne is the state capital and largest city in the Australian state of Victoria, and the second-largest city in Australia (after Sydney), with a population of approximately 3. ... Gustav Joseph Victor Nossal (born June 4, 1931 in Vienna, Austria) is a distinguished research scientist. ... Sir Frank MacFarlane Burnet (September 3, 1899–August 31, 1985) was an Australian biologist. ... A lymphocyte is a type of white blood cell involved in the human bodys immune system. ... T cells are a subset of lymphocytes that play a large role in the immune response. ... B cells are lymphocytes that play a large role in the humoral immune response (as opposed to the cell-mediated immune response). ... Schematic of antibody binding to an antigen An antibody is a protein used by the immune system to identify and neutralize foreign objects like bacteria and viruses. ... In human anatomy, the thymus is a ductless gland located in the upper anterior portion of the chest cavity. ... T cells are a subset of lymphocytes that play a large role in the immune response. ... T cells are a subset of lymphocytes that play a large role in the immune response. ... Immunology is a broad branch of biomedical science that covers the study of all aspects of the immune system in all organisms. ... When normal cells are damaged beyond repair, they are eliminated by apoptosis. ... Autoimmune diseases arise from an overactive immune response of the body against substances and tissues normally present in the body. ... The Red Ribbon is the global symbol for solidarity with HIV-positive people and those living with AIDS. Acquired immunodeficiency syndrome, or acquired immune deficiency syndrome (or acronym AIDS or Aids), is a collection of symptoms and infections resulting from the specific damage to the immune system caused by infection... Transplant rejection occurs when the immune system of the recipient of an transplant attacks the transplanted organ or tissue. ... An allergy or Type I hypersensitivity is an immune malfunction whereby a persons body is hypersensitised to react immunologically to typically nonimmunogenic substances. ...