He was the second director of Detroit Observatory (from 1863 to 1879), succeeding Franz Brünnow. He wrote the textbook Theoretical Astronomy in 1868.
He discovered 22 asteroids, beginning with 79 Eurynome in 1863. However, one of his asteroid discoveries, 139 Juewa was made in Beijing when Watson was there to observe the 1874transit of Venus. The name Juewa was chosen by Chinese officials (瑞華, or in modern pinyin, ruìhuá).
He was a strong believer in the existence of the planet Vulcan, a hypothetical planet closer to the Sun than Mercury, which is now known not to exist (however the existence of small Vulcanoid planetoids remains a possibility). He believed he had seen such two such planets during a July 1878 solar eclipse in Wyoming.
JamesWatson was only 25 years old when he and his older colleague, Francis Crick, discovered the structure of deoxyribonucleic acid (DNA) the building block of all life on Earth.
Watson and Crick won the Nobel Prize for Physiology and Medicine in 1962, but this was not the end of Watson's career in the public eye.
From 1988 to 1992 JamesWatson served as the first Director of the Human Genome Project at the National Institutes of Health, a massive project to decipher the entire genetic code of the human species.