Grimes graduated from Hampton Academy; attended Dartmouth College, Hanover, N.H.; studied law; moved west and commenced practice in the 'Black Hawk Purchase', Wisconsin Territory, afterward the site of Burlington, Iowa. He also engaged in agriculture. Grimes served as a member of the Iowa Territorial House of Representatives 1838–1839, 1843–1844. He served as Governor of Iowa 1854–1858;
James Wilson Grimes (October 20, 1816 – February 7, 1872), born in Deering, New Hampshire, was an American politician, serving as the Whig governor of and senator from Iowa.
Grimes served as a member of the Iowa Territorial House of Representatives 1838–1839, 1843–1844.
Grimes was elected as a Republican to the United States Senate in 1859 and reelected in 1865 He served from March 4, 1859, until December 6, 1869, when he resigned due to ill health.