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Encyclopedia > Korsakoff's syndrome
Korsakoff's syndrome
Classification & external resources
Thiamine
ICD-10 F10.6
ICD-9 291.1, 294.0
DiseasesDB 14107
eMedicine med/2405 
MeSH D020915

Korsakoff's syndrome (Korsakoff's psychosis, amnesic-confabulatory syndrome), is a degenerative brain disorder caused by the lack of thiamine (vitamin B1) in the brain. The syndrome is named after Sergei Korsakoff, the neuropsychiatrist who popularized the theory. Image File history File links Download high-resolution version (1100x423, 31 KB) File links The following pages on the English Wikipedia link to this file (pages on other projects are not listed): Thiamine ... For the similarly spelled nucleic acid, see Thymine Thiamine or thiamin, also known as vitamin B1, is one of the B vitamins. ... The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ... The International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) is a coding of diseases and signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or diseases, as classified by the World Health Organization (WHO). ... // F00-F99 - Mental and behavioural disorders (F00-F09) Organic, including symptomatic, mental disorders (F00) Dementia in Alzheimers disease (F01) Vascular dementia (F011) Multi-infarct dementia (F02) Dementia in other diseases classified elsewhere (F020) Dementia in Picks disease (F021) Dementia in Creutzfeldt-Jakob disease (F022) Dementia in Huntingtons... The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ... The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. ... The Disease Bold textDatabase is a free website that provides information about the relationships between medical conditions, symptoms, and medications. ... eMedicine is an online clinical medical knowledge base that was founded in 1996. ... Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ... For the similarly spelled nucleic acid, see Thymine Thiamine or thiamin, also known as vitamin B1, is one of the B vitamins. ... The human brain In animals, the brain (enkephalos) (Greek for in the skull), is the control center of the central nervous system, responsible for behavior. ... In medicine, the term syndrome is the association of several clinically recognizable features, signs, symptoms, phenomena or characteristics which often occur together, so that the presence of one feature alerts the physician to the presence of the others. ... Sergei Sergeievich Korsakoff (Russian: ; January 22, 1854, Vladimir- May 1, 1900, Moscow) was a Russian neuropsychiatrist. ... Neuropsychiatry is the branch of medicine dealing with mental disorders attributable to diseases of the nervous system. ...

Contents

Symptoms

There are six major symptoms of Korsakoff's syndrome: anterograde and retrograde amnesia, or severe memory loss; confabulation, that is, invented memories which are then taken as true due to gaps in memory sometimes associated with blackouts; meager content in conversation; lack of insight, and apathy (the patients lose interest in things quickly and generally appear indifferent to change).
Anterograde amnesia is a form of amnesia, or memory loss, in which new events are not transferred from short-term memory to long-term memory. ... Retrograde amnesia is a form of amnesia where someone will be unable to recall events that occurred before the onset of amnesia. ... For other uses, see Amnesia (disambiguation). ... Look up confabulation in Wiktionary, the free dictionary. ... A blackout is a phenomenon caused by the intake of alcohol in which long term memory creation is impaired. ... Look up Insight in Wiktionary, the free dictionary. ... This article does not cite any references or sources. ...


These symptoms are caused by a deficiency of thiamine (vitamin B1), which is thought to cause damage to the medial thalamus and possibly to the mammillary bodies of the hypothalamus as well as generalized cerebral atrophy.[1] For the similarly spelled nucleic acid, see Thymine Thiamine or thiamin, also known as vitamin B1, is one of the B vitamins. ... For the meaning of medial in anatomy, see anatomical terms of location. ... The thalamus (from Greek θάλαμος = bedroom, chamber, IPA= /ˈθæləməs/) is a pair and symmetric part of the brain. ... The mammillary bodies (Latin: corpus mamillare) are a pair of small round bodies in the brain forming part of the limbic system. ... Cerebral atrophy is a common feature of many of the diseases that affect the brain. ...


When Wernicke's encephalopathy accompanies Korsakoff's syndrome, the combination is called the Wernicke-Korsakoff syndrome. Korsakoff's is a continuum of Wernicke's encephalopathy, though a recognised episode of Wernicke's is not always obvious. This article describes the neurological syndrome Wernicke encephalopathy. ... Wernicke-Korsakoff syndrome is a combination of Korsakoffs syndrome, which is characterized by confusion, severe anterograde and retrograde amnesia and confabulation; and Wernickes encephalopathy, which is characterized by nystagmus, ophthalmoplegia, coma and, if untreated, death. ...


Korsakoff's involves neuronal loss, that is, damage to neurons; gliosis which is a result of damage to supporting cells of the central nervous system; and hemorrhage or bleeding in mammillary bodies. Damage to the dorsomedial nucleus of the thalamus is also associated with this disorder. Neurons (also spelled neurones or called nerve cells) are the primary cells of the nervous system. ... Neurons (also called nerve cells) are the primary cells of the nervous system. ... This page may meet Wikipedias criteria for speedy deletion. ... A diagram showing the CNS: 1. ... To meet Wikipedias quality standards, this article or section may require cleanup. ... The mammillary bodies (Latin: corpus mamillare) are a pair of small round bodies in the brain forming part of the limbic system. ... The Dorsomedial hypothalamic nucleus is a nucleus of the hypothalamus. ... The thalamus (from Greek θάλαμος = bedroom, chamber, IPA= /ˈθæləməs/) is a pair and symmetric part of the brain. ...


Indications

For other uses, see Ataxia (disambiguation). ... This article does not cite any references or sources. ... Retrograde amnesia is a form of amnesia where someone will be unable to recall events that occurred before the onset of amnesia. ... Anterograde amnesia is a form of amnesia, or memory loss, in which new events are not transferred from short-term memory to long-term memory. ... Look up confabulation in Wiktionary, the free dictionary. ... Paralysed redirects here. ... For other uses, see Coma (disambiguation). ...

Treatment

Treatment involves replacing the thiamine by intravenous (IV) or intramuscular (IM) injection, and providing proper nutrition and hydration. However, the amnesia and brain damage caused by the disease does not respond to thiamine replacement therapy. In some cases, drug therapy is recommended to the patient. If treatment is successful, signs will show within two years though recovery is slow and often incomplete. For the similarly spelled nucleic acid, see Thymine Thiamine or thiamin, also known as vitamin B1, is one of the B vitamins. ... An intravenous drip in a hospital Intravenous therapy or IV therapy is the administration of liquid substances directly into a vein. ... Intramuscular injection is an injection of a substance directly into a muscle. ... The Nutrition Facts table indicates the amounts of nutrients which experts recommend you limit or consume in adequate amounts. ... In chemistry, hydration is the condition of being combined with water. ... For the similarly spelled nucleic acid, see Thymine Thiamine or thiamin, also known as vitamin B1, is one of the B vitamins. ... This article is being considered for deletion in accordance with Wikipedias deletion policy. ... A patient having his blood pressure taken by a doctor. ...


Causes

Conditions resulting in the vitamin deficiency and its effects include chronic alcoholism, and severe malnutrition. Alcoholism is often an indicator of poor nutrition, which in addition to inflammation of the stomach lining, causes thiamine deficiency.[2] As well as alcohol abuse, causes include dietary deficiencies, prolonged vomiting, eating disorders, or the effects of chemotherapy. It can also occur in pregnant women who have a form of extreme morning sickness known as hyperemesis gravidarum.[3] Mercury poisoning can also cause it. Alcoholism is the consumption of, or preoccupation with, alcoholic beverages to the extent that this behavior interferes with the drinkers normal personal, family, social, or work life, and may lead to physical or mental harm. ... Percentage of population affected by malnutrition by country, according to United Nations statistics. ... An abscess on the skin, showing the redness and swelling characteristic of inflammation. ... This article needs cleanup. ... Chemotherapy is the use of chemical substances to treat disease. ... Hyperemesis gravidarum (from the Latin for extreme vomiting of the pregnant woman) is a severe form of morning sickness. ... It has been suggested that Acrodynia be merged into this article or section. ...


Due to malnutrition and a lack of Thiamine, the hippocampus begins to decay, leaving holes that disallows one's rehearsed information within short term memory to transfer to long term memory (anterograde amnesia) The hippocampus is structurally located inside the medial temporal lobe of the brain. ... Anterograde amnesia is a form of amnesia, or memory loss, in which new events are not transferred from short-term memory to long-term memory. ...


Case studies

A famous case study is recounted by Oliver Sacks in "The Lost Mariner", which can be found in The Man Who Mistook His Wife for a Hat. Oliver Sacks in 2005. ... The Man Who Mistook His Wife for a Hat is a 1985 book by neurologist Oliver Sacks describing the case histories of some of his patients. ...


Another case is that of the Australian artist Charles Blackman.[4] Charles Blackmans The Cigarette shop (Running home) (1934) Charles Blackman (born August 12, 1928) is an Australian artist. ...


In popular culture

  • In the movie Memento, Guy Pearce's character suffers a head injury that results in a condition of anterograde amnesia very similar to Korsakoff's syndrome.
  • In the movie Clean Slate, Dana Carvey's character suffers from Korsakoff's syndrome.
  • In the fictional show House, episode "Histories", the clinic patient suffers from Korsakoff's as a result of malnutrition
  • In the fictional show Masters of Science Fiction episode "A Clean Escape"
  • In the novel Mona Lisa Overdrive, the character Slick was incarcerated in a "chemo-penal unit" with "induced Korsakov's" [sic]
  • In the non-fictional television show Thinking allowed with Dr. Jeffrey Mislove Oliver Sacks discusses a Patient suffering from severe Korasakoff's Syndrome.

Anterograde amnesia is a form of amnesia, or memory loss, in which new events are not transferred from short-term memory to long-term memory. ... Released by MGM in 1994, it stars Dana Carvey and Valeria Golino. ... House, also known as House, M.D., is an American medical drama television series created by David Shore and executive produced by Shore and film director Bryan Singer. ... Histories is the tenth episode of the first season of House, which premiered on the FOX network on February 8, 2005. ... Masters of Science Fiction is an American television series from the creators of Masters of Horror for the ABC network. ... A Clean Escape is the first episode of Masters of Science Fiction which aired August 4, 2007. ... NAKAYUBI (ナカユビ; Middle Finger) Buster Zangai -Shape2- (残骸 -Shape2-; Wreck -Shape2-) Limbo Mona Lisa Girl (Shape 2) Sid Vicious on the Beach Black Cherry Genzai (原罪; Original Sin) Monster Ai no uta (愛ノ歌; Love Song Continuous Information Mona Lisa OVERDRIVE was named after the 1989 novel Mona Lisa Overdrive, by William Gibson. ... A prison is a place in which people are confined and deprived of a range of liberties. ... Oliver Sacks in 2005. ...

References

  1. ^ Kolb & Whishaw: Fundamentals of Human Neuropsychology, 2003, pages 473-473
  2. ^ http://www.alzheimers.org.uk/Facts_about_dementia/What_is_dementia/info_korsakoffs.htm
  3. ^ http://www.healthatoz.com/healthatoz/Atoz/common/standard/transform.jsp?requestURI=/healthatoz/Atoz/ency/korsakoffs_syndrome.jsp
  4. ^ http://www.theage.com.au/news/arts/artists-wonderland-is-back-in-town/2006/07/28/1153816384482.html

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