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Encyclopedia > LEPR
Leptin receptor
Identifiers
Symbol(s) LEPR; CD295; OBR
External IDs OMIM: 601007 MGI: 104993 Homologene: 1731
Orthologs
Human Mouse
Entrez 3953 16847
Ensembl na ENSMUSG00000057722
Uniprot na P48356
Refseq NM_001003679 (mRNA)
NP_001003679 (protein)		 NM_010704 (mRNA)
NP_034834 (protein)
Location na Chr 4: 101.22 - 101.31 Mb
Pubmed search [1] [2]

Leptin receptor, also known as LEPR, is a human gene. Look up Hugo in Wiktionary, the free dictionary. ... The Mouse Genome Informatics (MGI) website is run by The Jackson Laboratory. ... HomoloGene[1], a tool of the National Center for Biotechnology Information (NCBI)[2], is a system for automated detection of homologs (similarity attributable to descent from a common ancestor) among the annotated genes of several completely sequenced eukaryotic genomes. ... The Gene Ontology, or GO, project can be broadly split into two parts. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... Ensembl is a bioinformatics research project aiming to develop a software system which produces and maintains automatic annotation on selected eukaryotic genomes. It is run in a collaboration between the Wellcome Trust Sanger Institute and the European Bioinformatics Institute, an outstation of the European Molecular Biology Laboratory. ... UniProt is the universal protein database, a central repository of protein data created by combining Swiss-Prot, TrEMBL and PIR. This makes it the worlds most comprehensive resource on protein information. ... Medline is a comprehensive literature database of life sciences and biomedical information. ... For other uses, see Gene (disambiguation). ...



Leptin (LEP; MIM 164160), an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family.[supplied by OMIM][1]


References

  1. ^ Entrez Gene: LEPR leptin receptor.

Further reading

  • Heshka JT, Jones PJ (2001). "A role for dietary fat in leptin receptor, OB-Rb, function.". Life Sci. 69 (9): 987-1003. PMID 11508653. 
  • Tartaglia LA, Dembski M, Weng X, et al. (1996). "Identification and expression cloning of a leptin receptor, OB-R.". Cell 83 (7): 1263-71. PMID 8548812. 
  • Chen H, Charlat O, Tartaglia LA, et al. (1996). "Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice.". Cell 84 (3): 491-5. PMID 8608603. 
  • Cioffi JA, Shafer AW, Zupancic TJ, et al. (1996). "Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction.". Nat. Med. 2 (5): 585-9. PMID 8616721. 
  • Considine RV, Considine EL, Williams CJ, et al. (1996). "The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations.". Diabetes 45 (7): 992-4. PMID 8666155. 
  • Chung WK, Power-Kehoe L, Chua M, Leibel RL (1996). "Mapping of the OB receptor to 1p in a region of nonconserved gene order from mouse and rat to human.". Genome Res. 6 (5): 431-8. PMID 8743992. 
  • Bennett BD, Solar GP, Yuan JQ, et al. (1997). "A role for leptin and its cognate receptor in hematopoiesis.". Curr. Biol. 6 (9): 1170-80. PMID 8805376. 
  • Winick JD, Stoffel M, Friedman JM (1997). "Identification of microsatellite markers linked to the human leptin receptor gene on chromosome 1.". Genomics 36 (1): 221-2. doi:10.1006/geno.1996.0455. PMID 8812446. 
  • Luoh SM, Di Marco F, Levin N, et al. (1997). "Cloning and characterization of a human leptin receptor using a biologically active leptin immunoadhesin.". J. Mol. Endocrinol. 18 (1): 77-85. PMID 9061609. 
  • Echwald SM, Sørensen TD, Sørensen TI, et al. (1997). "Amino acid variants in the human leptin receptor: lack of association to juvenile onset obesity.". Biochem. Biophys. Res. Commun. 233 (1): 248-52. doi:10.1006/bbrc.1997.6430. PMID 9144432. 
  • Thompson DB, Ravussin E, Bennett PH, Bogardus C (1997). "Structure and sequence variation at the human leptin receptor gene in lean and obese Pima Indians.". Hum. Mol. Genet. 6 (5): 675-9. PMID 9158141. 
  • Gotoda T, Manning BS, Goldstone AP, et al. (1997). "Leptin receptor gene variation and obesity: lack of association in a white British male population.". Hum. Mol. Genet. 6 (6): 869-76. PMID 9175732. 
  • Bailleul B, Akerblom I, Strosberg AD (1997). "The leptin receptor promoter controls expression of a second distinct protein.". Nucleic Acids Res. 25 (14): 2752-8. PMID 9207021. 
  • Chung WK, Power-Kehoe L, Chua M, et al. (1997). "Exonic and intronic sequence variation in the human leptin receptor gene (LEPR).". Diabetes 46 (9): 1509-11. PMID 9287054. 
  • Bjørbaek C, Uotani S, da Silva B, Flier JS (1998). "Divergent signaling capacities of the long and short isoforms of the leptin receptor.". J. Biol. Chem. 272 (51): 32686-95. PMID 9405487. 
  • Clément K, Vaisse C, Lahlou N, et al. (1998). "A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction.". Nature 392 (6674): 398-401. doi:10.1038/32911. PMID 9537324. 
  • Carpenter LR, Farruggella TJ, Symes A, et al. (1998). "Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor.". Proc. Natl. Acad. Sci. U.S.A. 95 (11): 6061-6. PMID 9600917. 
  • Kielar D, Clark JS, Ciechanowicz A, et al. (1998). "Leptin receptor isoforms expressed in human adipose tissue.". Metab. Clin. Exp. 47 (7): 844-7. PMID 9667233. 
  • Haniu M, Arakawa T, Bures EJ, et al. (1998). "Human leptin receptor. Determination of disulfide structure and N-glycosylation sites of the extracellular domain.". J. Biol. Chem. 273 (44): 28691-9. PMID 9786864. 
  • Haft CR, de la Luz Sierra M, Barr VA, et al. (1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors.". Mol. Cell. Biol. 18 (12): 7278-87. PMID 9819414. 
 

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