A lead compound in drug discovery is a chemical compound that has pharmacological or biological activity and whose chemical structure is used as a starting point for chemical modifications in order to improve potency, selectivity, or pharmacokinetic parameters. In medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are discovered and/or designed. ... Pharmacology (in Greek: pharmacon (φάÏμακον) meaning drug, and logos (λόγος) meaning science) is the study of how substances interact with living organisms to produce a change in function. ... It has been suggested that this article or section be merged with Bioactivity. ... Chemical structure refers to the spatial arrangement of atoms in a molecule and the chemical bonds that hold the atoms together. ... Chemistry - the study of atoms, made of nuclei (conglomeration of center particles) and electrons (outer particles), and the structures they form. ... Erectile dysfunction, also known as impotence, is the inability to develop or maintain an erection of the penis for satisfactory sexual intercourse regardless of the capability of ejaculation. ... The word selectivity has more meanings: Selectivity, the ability to notice/distinguish small differences. ... Pharmacokinetics is a branch of pharmacology dedicated to the study of the time course of substances and their relationship with an organism or system. ...
Lead compounds are often found in high-throughput screenings ("hits") or are secondary metabolites from natural sources. It has been suggested that Virtual_high_throughput_screening be merged into this article or section. ... Secondary metabolites are those chemical compounds in organisms that are not directly involved in the normal growth, development or reproduction of organisms. ...
The chemical compound lead(II) nitrate is the inorganic salt of nitric acid and lead.
Lead nitrate is used in the manufacture of matches and special explosives such as lead azide, in mordants for dyeing and printing calico textiles, in the manufacture of leadcompounds, as heat stabilizer in nylon and polyesters, as coating of photothermograpic paper, and rodenticides.
Is it reported that lead nitrate has an effect on the leaching process in gold cyanidation, improving speed and yield, particularly in processing partially oxidized ores.
Like calcium, lead becomes deposited in the bones, and is mobilized in times of stress, fatigue, growth and reproduction; hence the effects of lead are amplified in children and pregnant women.
The effects of lead are vague and lead poisoning, especially chronic low level poisoning, is difficult to diagnose, hence it is usually detected in the latter stages, where the damage is already done, and the effects are relatively permanent.
Chronic exposure to lead has been confirmed as leading to memory loss, and reduced IQ levels in children, along with anemia, hearing and speech impairment, low resistance to diseases, mental retardation, reduced growth and stature, brittle bones, degradation of posture, muscular dysfunction and kidney dysfunction.
Feeds |
Contact