Fatigue is a feeling of excessive tiredness or lethargy, with a desire to rest, perhaps to sleep. Often it causes yawning.
It is typically the result of working, mental stress, jet lag or active recreation, but also from boredom or disease or simply lack of sleep. It may also have chemical causes, such as poisoning or mineral or vitamin or deficiencies.
Fatigue can also be quite dangerous when performing certain duties that require constant concentration, such as driving a vehicle. When someone is sufficiently fatigued, they may experience microsleeps that can cause them to lose concentration.
Lethargy is a physical state of sluggishness, apathy (indifference), inattention and/or reduced physical activity, usually from illness, overwork or chemical exposure.
Lethargy or drowsiness may be a symptom of acute (short-term) exposure to certain chemicals.
Inhalation of vapors or gases is a common cause of lethargy.
Lethargy should not be ignored; it is a nonspecific sign associated with multiple possible underlying disorders.
Lethargy is a state of drowsiness, inactivity, or indifference in which there are delayed responses to external stimuli such as auditory (sound), visual (sight), or tactile (touch) stimuli.
As lethargy is a very nonspecific sign and is associated with dozens of physical ailments, baseline laboratory tests are useful in identifying any systemic abnormalities that should be pursued with further testing.