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Encyclopedia > Levorphanol
Levorphanol chemical structure
Levorphanol
Systematic (IUPAC) name
17-methylmorphinan-3-ol
Identifiers
CAS number 77-07-6
ATC code  ?
PubChem 5359272
DrugBank APRD00764
Chemical data
Formula C17H23NO
Mol. weight 257.371 g/mol
SMILES CN1CCC23CCCCC2C1CC4=C3C=C(C=C4)O
Physical data
Melt. point 23 °C (73 °F)
Pharmacokinetic data
Bioavailability  ?
Protein binding 40%
Metabolism  ?
Half life 11-16 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

C(US) Image File history File links Levorphanol. ... IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... The simplified molecular input line entry specification or SMILES is a specification for unambiguously describing the structure of chemical molecules using short ASCII strings. ... The melting point of a crystalline solid is the temperature at which it changes state from solid to liquid. ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Many drugs are bound to Blood plasma proteins. ... It has been suggested that this article or section be merged with cell metabolism and carbohydrates. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ... Motto: (Out Of Many, One) (traditional) In God We Trust (1956 to date) Anthem: The Star-Spangled Banner Capital Washington D.C. Largest city New York City None at federal level (English de facto) Government Federal constitutional republic  - President George Walker Bush (R)  - Vice President Dick Cheney (R) Independence from...

Legal status

Schedule II(US) The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... // The Controlled Substances Act (CSA) was enacted into law by the Congress of the United States as Title II of the Comprehensive Drug Abuse Prevention and Control Act of 1970 (21 USC 801 et sequitur). ... Motto: (Out Of Many, One) (traditional) In God We Trust (1956 to date) Anthem: The Star-Spangled Banner Capital Washington D.C. Largest city New York City None at federal level (English de facto) Government Federal constitutional republic  - President George Walker Bush (R)  - Vice President Dick Cheney (R) Independence from...

Routes oral, intravenous, intramuscular, subcutaneous

Levorphanol is an opioid medication used to treat severe pain. The medication has a known abuse potential. In addition to acting on opioid receptors, it also acts on NMDA receptors. Typical doses include 2 mg by mouth or subcutaneous injection every 6 to 8 hours. In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... An opioid is any agent that binds to opioid receptors, found principally in the central nervous system and gastrointestinal tract. ... The NMDA receptor (NMDAR) is an ionotropic receptor for glutamate (NMDA (N-methyl d-aspartate) is a name of its selective specific agonist). ... The subcutis is the layer of tissue directly underlying the cutis. ...


It is chemically related to dextromethorphan, an antitussive, which is not an opioid. Dextromethorphan is a salt of the methyl ether dextrorotatory isomer of levorphanol. Dextromethorphan (DM or DXM) is an antitussive drug that is found in many over-the-counter cold and cough preparations, usually in the form of dextromethorphan hydrobromide. ... A cough medicine is a drug used to treat coughing and related conditions. ... Dextromethorphan (DM or DXM) is an antitussive drug that is found in many over-the-counter cold and cough preparations, usually in the form of dextromethorphan hydrobromide. ... A magnified crystal of a salt (halite/sodium chloride) A salt, in chemistry, is any ionic compound composed of cations (positively charged ions) and anions (negative ions) so that the product is neutral (without a net charge). ... Dimethyl ether, also known as methoxymethane, oxybismethane, methyl ether, wood ether, and DME, is a colorless gaseous ether with an ethereal odor. ...


  Results from FactBites:
 
Levorphanol and Racemorphan Synthesis by DopaMan (2758 words)
Levomethorphan, or levorphanol methyl ether, by the way, is a powerful opioid analgesic, which I would place (making an educated "guesstimate"), on the opioid scale, at approximately the some potency level as hydrocodone (Vicodin), or one half as potent as morphine.
Levorphanol, or the pure opioid, and levorotatory component of racemorphan, is six to eight times as potent as morphine; almost three times as potent as heroin; and is twice as powerful as racemorphan.
Whether racemorphan or levorphanol is used, it is crucial that one has a scale with the ability to measure accurately down to 1 to 2 milligrams.
ACS :: Cancer Drug Guide: levorphanol tartrate (614 words)
Levorphanol tartrate relieves moderate to severe pain and is similar to morphine.
Since levorphanol tartrate affects the central nervous system (CNS), it is important not to take other drugs or substances that are known CNS depressants such as alcohol, sedatives, and hypnotics.
Acetaminophen or aspirin may be combined with levorphanol tartrate to increase the pain relief action.
  More results at FactBites »


 

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