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Levothyroxine
Identifiers
CAS	51-48-9
ATC	H03AA01
PubChem	853
DrugBank	APRD00235
Chemical data
IUPAC name	3,5,3',5'-tetraiodo-L-thyronine
Formula	C15H10I4NNaO4 * H2O
Mol. weight	798.86 (anhydrous)
Pharmacokinetic data
Bioavailability
%Protein Bound	{{{protein_bound}}}
Metabolism	Mainly in liver, kidneys, brains and muscles
Half life	ca. 7 days (in hyperthyroidism 3-4 days, in hypothyroidism 9-10 days)
Excretion	Through faeces and urine
Therapeutic considerations
Pregnancy
Legal status
Dependence Liability	{{{dependency_liability}}}
Routes	Oral

Levothyroxine, also known as L-thyroxine, synthetic T4 or simply 3,5,3',5'-tetraiodo-L-thyronine, is a synthetic form of thyroxine (thyroid hormone). As the hormone is chemically in the L-form (instead of D, see chirality), it is metabolised much slower than physiological thyroid hormone, which has a shorter half-life. CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... You may be looking for albumen, or egg white. ... Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος (metabolismos)) is the biochemical modification of chemical compounds in living organisms anggjgjhnd cell (b). ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother. ... The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are tyrosine-based hormones produced by the thyroid gland. ... The term chiral (pronounced ki-rall) is used to describe an object which is non-superimposable on its mirror image. ...

The EU has recently standardised the use of the name "levothyroxine" for the drug. Common brand names include "Thyrax", "Euthyrox", "Levaxin" and "Eltroxin" in Europe, and "Levoxyl" and "Synthroid" in the US. This article is about brands in marketing. ... Synthroid is the brand name used by Abbott Laboratories for levothyroxine sodium (T4, a synthetic thyroid hormone) product. ...

This medicine is usually given to patients with thyroid problems. These many problems can affect the patient's (if he/she is a child/teenager) growth and/or weight.

It is recommended that levothyroxine is taken an hour before meals to maximise its absorption.

External links

• Detailed Euthyrox (Levothroid/Levothyroxine) Consumer Information: Uses, Precautions, Side Effects