Schematic diagram of an typical antibody showing two Ig heavy chains (blue) linked by disulphide bonds to two Ig light chains (green). The constant (C) and variable (V) domains are shown.
An antibody molecule. The two heavy chains are colored red and blue and the two light chains green and yellow. See also: [1] A light chain is the small polypeptide subunit of an antibody (or immunoglobulin); a typical antibody is composed of two immunoglobulin (Ig) heavy chains and two Ig light chains. Image File history File links Anticorps. ...
Image File history File links Anticorps. ...
A disulfide bond (SS-bond), also called a disulfide bridge, is a strong covalent bond between two sulfhydryl groups. ...
Image File history File links Size of this preview: 800 × 587 pixel Image in higher resolution (960 × 704 pixel, file size: 244 KB, MIME type: image/png) Structure of an antibody. ...
Image File history File links Size of this preview: 800 × 587 pixel Image in higher resolution (960 × 704 pixel, file size: 244 KB, MIME type: image/png) Structure of an antibody. ...
Peptides are the family of molecules formed from the linking, in a defined order, of various amino acids. ...
Each antibody binds to a specific antigen; an interaction similar to a lock and key. ...
Schematic of antibody binding to an antigen An antibody is a protein used by the immune system to identify and neutralize foreign objects like bacteria and viruses. ...
In humans
There are two types of light chain in mammals, - lambda (λ) chain (1, 2, 3, and 4)
- kappa (κ) chain (only one type)
In other animals Other types of light chains can be found in lower vertebrates, such as the Ig-Light-Iota chain of Chondrichthyes and Teleostei.[1][2] Classes and Clades See below Male and female Superb Fairy-wren Vertebrates are members of the subphylum Vertebrata (within the phylum Chordata), specifically, those chordates with backbones or spinal columns. ...
This article does not cite its references or sources. ...
Orders See text The Actinopterygii are the ray-finned fish. ...
Camelids are unique among mammals as they have fully functional antibodies which have two heavy chains, but lack the light chains usually paired with each heavy chain.[3] The functional role of this separate repertoire is unknown as yet. Species Lama glama Lama guanicoe Vicugna pacos Vicugna vicugna Camelus dromedarius Camelus bactrianus The four llamas and two camels are camelids: members of the biological family Camelidae, the only family in the suborder Tylopoda. ...
Structure Only one type of light chain is present in a typical antibody, thus the two light chains of an individual antibody are identical.
Each light chain is composed of two tandem immunoglobulin domains: Example of an immunoglobulin domain, the fibronectin type III domain from human tenascin (PDB accesion code 1TEN), colored from blue (N-terminus) to red (C-terminus). ...
- one constant (IgC) domain
- one variable domain (IgV) that is important for binding antigen
The approximate length of a light chain protein is from 211 to 217 amino acids.[1] An antigen is a substance that stimulates an immune response, especially the production of antibodies. ...
Phenylalanine is one of the standard amino acids. ...
References - ^ a b Janeway CA, Jr. et al (2001). Immunobiology., 5th ed., Garland Publishing. (electronic full text via NCBI Bookshelf) ISBN 0-8153-3642-X.
- ^ IMGT Index Antibodies (or Immunoglobulins).
- ^ Hamers-Casterman C, Atarhouch T, Muyldermans S, Robinson G, Hamers C, Songa E, Bendahman N, Hamers R (1993). "Naturally occurring antibodies devoid of light chains". Nature 363 (6428): 446-8. PMID 8502296.
Charles Alderson Janeway, Jr. ...
External links MAC complex - Nanobodies - Perforin - Antibodies (Light chain, Heavy chain, IgA, IgD, IgE, IgG, IgM) Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ...
A scanning electron microscope image of a single neutrophil (yellow), engulfing anthrax bacteria (orange). ...
A representation of the 3D structure of myoglobin, showing coloured alpha helices. ...
The membrane attack complex (MAC) is formed on the surface of intruding pathogenic bacterial cells as a result of the activation of the complement system, and it is one of the ultimate weapons of the immune system. ...
Nanobodies are a type of antibodies derived from camels, and are much smaller than traditional antibodies. ...
Perforin is a cytolytic protein found in the granules of CD8 T-cells and NK cells. ...
Each antibody binds to a specific antigen; an interaction similar to a lock and key. ...
Schematic of antibody binding to an antigen An antibody is a protein used by the immune system to identify and neutralize foreign objects like bacteria and viruses. ...
...
...
Immunoglobulin E (IgE) is an antibody subclass (known as isotypes), found only in mammals. ...
Molecular surface of an IgG molecule IgG is a monomeric immunoglobulin, built of two heavy chains γ and two light chains. ...
IgM (Immunglobulin M) antibody molecule consisting of 5 base units. ...
|
![[1]](http://www.emc.maricopa.edu/faculty/farabee/BIOBK/ANTIBODY.gif){kind=link}
Feeds |
Contact