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An oily, sustained counter-regulatory response to TB -- Karp and Cooper 115 (6): 1473 -- Journal of Clinical ... (1657 words) |
 | Lipoxins are potent antiinflammatory lipid mediators that restrain |
| lipoxin analogs for the therapy of tissue inflammatory diseases. |
| Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis. |
| Product News and Information (1103 words) |
| Analyses of the lipoxin analog's mechanism of action revealed a novel role for lipoxins in blocking the cellular cascade of dysfunctional immune responses that leads to inflammation in the mucosal lining of the gastrointestinal tract. |
| Lipoxin - technically called lipoxin A4 - is a lipid mediator (fatty acid derived molecule) generated by the immune system as part of the response to antigens and inflammation by lipoxygenase-dependent arachidonic acid metabolism. |
| Naturally occurring lipoxin A4 promotes the resolution of inflammation and modulates immune cell activity via potent agonist actions at lipoxin receptors on granulocytes, macrophages, dendritic cells, T lymphocytes, and epithelial cells. |
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