This is a list of destroyer classes of the United States Navy.

• Bainbridge class — 13 ships, 1900–1902
• Truxtun class — 3 ships, 1901
• Smith class — 5 ships, 1908–1909
• Paulding class — 21 ships, 1909–1912
• Cassin class — 8 ships, 1912–1913
• O'Brien class — 6 ships, 1914–1915
• Tucker class — 6 ships, 1915
• Sampson class — 6 ships, 1916
• Caldwell class — 6 ships, 1917–1918
• Wickes class — 111 ships, 1917–1919
• Clemson class — 164 ships, 1919–1921
• Farragut class — 8 ships, 1934–1935
• Porter class — 8 ships, 1935–1936
• Mahan class — 18 ships, 1936–1936
• Gridley class — 4 ships, 1936–1938
• Bagley class — 8 ships, 1936–1937
• Somers class — 5 ships, 1937–1938
• Benham class — 10 ships, 1938–1939
• Sims class — 12 ships, 1938–1939
• Benson class — 96 ships, 1939–1943
• Fletcher class — 175 ships, 1942–1944
• Allen M. Sumner class — 58 ships
• Gearing class — 98 ships, 1944–1946
• Mitscher class — 4 ships, 1952
• Dealey class — 13 ships, 1953–1957
• Forrest Sherman class — 18 ships, 1956–1958
• Claud Jones class — 4 ships, 1958–1959
• Farragut class — 10 ships, 1958–1960
• Charles F. Adams class — 23 ships, 1959–1963
• Spruance class — 30 ships, 1973–1979
• Kidd class, a modified Spruance class — 5 ships, 1979–1982
• Arleigh Burke class — 36 ships, 1989– (further ships are being constructed or planned)
• DD(X)