The Little River flows from headwaters in northern South Carolina into Lake Keowee. It exits via Little River Dam and then joins the Keowee River to form the Seneca River (Savannah River). Official language(s) English Capital Charleston(1670-1789) Columbia(1790-present) Largest city Columbia Largest metro area Columbia Area  Ranked 40th  - Total 34,726 sq mi (82,965 km²)  - Width 200 miles (320 km)  - Length 260 miles (420 km)  - % water 6  - Latitude 32°430N to 35°12N... Lake Keowee is a reservoir created by Keowee Dam and Little River Dam. ... The Keowee River is created by the confluence of the Toxaway River and the Whitewater River in northern South Carolina. ... The Seneca River is created by the confluence of the Keowee River and the Little River in northern South Carolina, just downriver from Lake Keowee. ...

The Little River was in the heart of the Cherokee Lower Towns region. Several Cherokee towns were located along the river. For other uses, see Cherokee (disambiguation). ...