Louise McIntosh Slaughter (b. August 14, 1929) is a politician from the state of New York.

Slaughter was born in Harlan County, Kentucky and she graduated from the University of Kentucky. Slaughter is a descendant of Daniel Boone and a distant cousin of Ike Skelton. She worked as a staffer for Mario Cuomo and she was elected to the New York General Assembly in 1982 as a Democrat. She won a seat in the House of Representatives in 1986. Slaughter's district was altered in redistricting in 2002. She narrowly avoided a primary battle against fellow Democratic congressman John LaFalce when LaFalce retired.