In the fictional Star Fleet Universe as represented in the range of games from Amarillo Design Bureau Inc. as well as the first two Star Fleet Command games (and the Orion Pirates stand-alone addon for Starfleet Command II) from Taldren, the Lyrans are a felinoid race possessing a stellar empire which borders the Hydran Kingdoms, the Klingon Empire as well as their fierce rivals, the Kzinti Hegemony.

Lyrans as a species are aggressive and prone to internecine strife, indeed the external frontiers of the Lyran Star Empire have remained static for considerable periods of Lyran history due to this. Lyrans generally possess an abiding racial hatred of the Kzinti, one which is more than amply reciprocated by said race, while also disdaining the methane-breathing Hydrans. Interestingy, DNA evidence exists showing a common ancestry between the Lyrans and the Kzinti, yet neither race take what to their ears is a highly offensive suggestion lightly.

The Lyrans have been allies of the Klingons on numerous occasions, such as during the Four Powers' War and the far more destructive General War, in which they very nearly succeeded in reducing their hated Kzinti foes to subjugation, and the two races have jointly conquered and occupied the territory of the Hydrans on more than one occasion.