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Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural crest -- Kwang et al. ... (7453 words) |
 | Upregulation of Msx2 in the postotic hindbrain of Splotch mutant embryos |
| the upregulation of Msx2 in Splotch mutant embryos. |
| Msx2 in the neural tube and cardiac neural crest. |
| MINT, the Msx2 Interacting Nuclear Matrix Target, Enhances Runx2-dependent Activation of the Osteocalcin Fibroblast ... (6519 words) |
| Indeed, in the simultaneous absence of Msx2 and Msx1, a |
| The Ku antigen complex (Ku70, Ku80, and Tbdn100) is recruited by interactions with Runx2 and OCFRE cognates, increasing OCFRE-dependent transcription (18, 32, 41), increased recruitment of Ku antigen to genomic targets such as the OC gene serves to enhance the efficiency of transcriptional re-initiation. |
| To inhibit OC transcription, Msx2 reduces the steady-state levels of Runx2-dependent transactivation complexes associated with the OCFRE (15, 16); this is achieved via antagonistic protein-protein interactions with both MINT and Ku. |
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