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Encyclopedia > Mammalian embryogenesis

Mammalian embryogenesis is the process of cell division and cellular differentiation which leads to the development of a mammalian embryo. This article or section does not cite its references or sources. ... Embryonic stem cells differentiate into cells in various body organs. ... Orders Subclass Multituberculata (extinct) Plagiaulacida Cimolodonta Subclass Palaeoryctoides (extinct) Subclass Triconodonta (extinct) Subclass Eutheria (excludes extinct ancestors) Afrosoricida Anagaloidea (extinct) Artiodactyla Carnivora Cetacea Chiroptera Cimolesta (extinct) Creodonta (extinct) Condylarthra (extinct) Dermoptera Desmostylia (extinct) Dinocerata (extinct) Embrithopoda (extinct) Hyracoidea Insectivora Lagomorpha Litopterna (extinct) Macroscelidea Mesonychia (extinct) Notoungulata (extinct) Perissodactyla Pholidota Plesiadapiformes... Embryos (and one tadpole) of the wrinkled frog (Rana rugosa). ...

Contents


From one cell to blastocyst

A mammal develops from a single cell called a zygote, which results from an oocyte (egg) being fertilized by a single sperm. The zygote is surrounded by a strong membrane of glycoproteins called the zona pellucida which the successful sperm has managed to penetrate. This article or section does not cite its references or sources. ... An oocyte or ovocyte is a female gametocyte that divides twice by mitosis and meiosis into two other oocytes or into two ootids. ... Categories: Biology stubs ... The signifier sperm can refer to: (mass noun, from Greek sperma = seed) a substance which consists of spermatozoa and which is a component of semen (mass noun) semen itself (informally, count noun with plural sperm or sperms) a single spermatozoon (= sperm cell) sperma ceti (Latin ceti, genitive of cetus = whale... A glycoprotein is a macromolecule composed of a protein and a carbohydrate (a sugar). ... The zona pellucida is a glycoprotein membrane surrounding the plasma membrane of an oocyte. ...


The zygote undergoes cleavage, increasing the number of cells within the zona pellucida. When there are about 4 to 16 cells, the embryo is in the morula stage. When the number of cells reaches 40 to 150, a central, fluid-filled cavity (blastocoel) forms. The zona pellucida begins to degenerate. This stage in the developing embryo, reached after four to six days, is the blastocyst(blastula stage), and lasts approximately until the implantation in the uterus. The outer cells develop into the placenta. In embryology, cleavage is the division of cells in the early embryo. ... Morula is a stage of embryonic development in animals, including the 16-cell phase, the 32-cell phase, and the 64-cell phase. ... A blastocoel(e) or blastocele or cleavage cavity or segmentation cavity is the central region of a blastula (or blastosphere). ... The uterus or womb is the major female reproductive organ of most mammals, including humans. ... The placenta is an ephemeral (temporary) organ present only in female placental mammals during gestation (pregnancy). ...


Blastocyst grows and invades

Blastocyst with an inner cell mass and trophoblast.
Blastocyst with an inner cell mass and trophoblast.

In the blastocyst there are cells which eventually form the placenta, and inner cell mass (also called embryoblast) of undifferentiated cells which are a source of embryonic stem cells. The blastocyst can be thought of as a ball of a (mostly single) layer of trophoblast cells, with inner cell mass attached to this ball's inner wall. The embryo plus its membranes is called the conceptus. By this stage the conceptus is in the uterus. The zona pellucida ultimately disappears. Blastocyst. ... The inner cell mass is surrounded by the single cell layer of cells called trophoblast. ... The trophoblast (from Greek threphein: to feed) is considered to be the first of all embryonic annexes. ... Embryogenesis is the process of cell division and cellular differentiation which leads to the development of an embryo. ... The placenta is an ephemeral (temporary) organ present only in female placental mammals during gestation (pregnancy). ... The inner cell mass is surrounded by the single cell layer of cells called trophoblast. ... Mouse embryonic stem cells. ... The trophoblast (from Greek threphein: to feed) is considered to be the first of all embryonic annexes. ... It has been suggested that Net flux be merged into this article or section. ... Conceptus (latin is conceptio, derivatives of zygote) The embryo and its adnexa (appendages or adjunct parts) or associated membranes (i. ... The uterus or womb is the major female reproductive organ of most mammals, including humans. ... The zona pellucida is a glycoprotein membrane surrounding the plasma membrane of an oocyte. ...


The trophoblast then differentiates into two distinct layers: the inner is the cytotrophoblast consisting of cuboidal cells that are the source of dividing cells, and the outer is the syncytiotrophoblast. The trophoblast (from Greek threphein: to feed) is considered to be the first of all embryonic annexes. ... The introduction to this article provides insufficient context for those unfamiliar with the subject matter. ... Cells in culture, stained for keratin (red) and DNA (green). ... Syncytiotrophoblasts are cells found in the placenta of human embryos. ...


The cytotrophoblast implants the blastocyst in the endometrium (innermost epithelial lining) of the uterus by forming finger-like projections called villi that make their way into the uterus, and spaces called lacunae that fill up with the mother's blood. This is assisted by hydrolytic enzymes that erode the epithelium. The syncytiotrophoblast also produces human chorionic gonadotropin (hCG), a hormone that "notifies" the mother's body (though not necessarily the mother) that she is pregnant, which prevents menstruation The endometrium is the inner uterine membrane in mammals which is developed in preparation for the implantation of a fertilized egg upon its arrival into the uterus. ... In zootomy, epithelium is a tissue composed of a layer of cells. ... A lacuna is a gap in a manuscript, inscription or text. ... Hydrolysis is a chemical process in which a molecule is cleaved into two parts by the addition of a molecule of water. ... Ribbon diagram of the enzyme TIM. TIM is catalytically perfect, meaning its conversion rate is limited, or nearly limited to its substrate diffusion rate. ... In zootomy, epithelium is a tissue composed of a layer of cells. ... Syncytiotrophoblasts are cells found in the placenta of human embryos. ... Human chorionic gonadotropin (hCG) is a peptide hormone produced in pregnancy, that is made by the embryo soon after conception and later by the trophoblast (part of the placenta). ... A hormone (from Greek horman - to set in motion) is a chemical messenger from one cell (or group of cells) to another. ... A pregnant woman Pregnancy is the process by which a mammalian female carries a live offspring from conception until it develops to the point where the offspring is capable of living outside the womb. ...


The villi begin to branch, and contain blood vessels of the fetus that allow gas exchange between mother and child. Fetus at eight weeks Foetus redirects here. ...


Inner cell mass differentiation

A human blastocyst
A human blastocyst

While the syncytiotrophoblast starts to penetrate into the wall of the uterus, the inner cell mass (embryoblast) also develops. The blastocyst stage of development in the embryos of humans is around 5 days old with 30-150 cells. ... The blastocyst stage of development in the embryos of humans is around 5 days old with 30-150 cells. ...


The embryoblast forms a bilaminar (two layered) embryo, composed of the epiblast and the hypoblast. The epiblast is adjacent to the trophoblast and made of columnar cells; the hypoblast is closest to the blastocyst cavity, and made of cuboidal cells. The epiblast, now called primitive ectoderm will give rise to all three germ layers of the embryo: ectoderm, mesoderm, and endoderm. The hypoblast, or primitive endoderm, will give rise to extraembryonic structures only, such as the lining of the yolk sac. It has been suggested that this article or section be merged with Embryogenesis. ... In embryology, the epiblast is a feature present during gastrulation. ... It has been suggested that organogenesis be merged into this article or section. ...


Cavity formation

By separating from the trophoblast, the epiblast forms a new cavity, the amniotic cavity. This is lined by the amnionic membrane, with cells that come from the epiblast (called amnioblasts). Some hypoblast cells migrate along the inner cytotrophoblast lining of the blastocoel, secreting an extracellular matrix along the way. These hypoblast cells and extracellular matrix are called Heuser's membrane (or exocoelomic membrane), and the blastocoel is now called the primary yolk sac (or exocoelomic cavity). In biology, extracellular matrix (ECM) is any material part of a tissue that is not part of any cell. ...


Cytotrophoblast cells and cells of Heuser's membrane continue secreting extracellular matrix between them. This matrix is called the extraembryonic reticulum. Cells of the epiblast migrate along the outer edges of this reticulum and form the extraembryonic mesoderm, which makes it difficult to maintain the extraembryonic reticulum. Soon pockets form in the reticulum, which ultimately coalesce to form the chorionic cavity or extraembryonic coelom.


Another layer of cells leaves the hypoblast and migrates along the inside of the primary yolk sac. The primary yolk sac is pushed to the opposite side of the embryo (the abembryonic pole), while a new cavity forms, the secondary or definitive yolk sac. The remnants of the primary yolk sac are called exocoelomic vesicles.


See also

Embryogenesis is the process by which the embryo is formed and develops. ... Drosophila has long been a favorite model system for geneticists and developmental biologists studying embroygenesis. ... Plant embryogenesis is a sexual or asexual reproductive process that forms new plants. ... Developmental biology is the study of the process by which organisms grow and develop. ... A blastomere is the structure which results from the divisions of a fertilised egg during embryonic development . ... Morula is a stage of embryonic development in animals, including the 16-cell phase, the 32-cell phase, and the 64-cell phase. ...

External links

Mammalian embryogenesis/Embryology and Fetal development - edit

Embryo/Carnegie stages: Zygote | Morula | Blastula/Blastomere/Blastosphere | Gastrula/Gastrulation | Neurula | Fetus Embryology is the branch of developmental biology that studies embryos and their development. ... Fetal development is the process in which a fetus develops during gestation, from the time of conception until birth. ... Embryos (and one tadpole) of the wrinkled frog (Rana rugosa). ... In embryology, Carnegie stages are a standardized system of 23 stages used to provide a unified developmental chronology of the embryo. ... This article or section does not cite its references or sources. ... Morula is a stage of embryonic development in animals, including the 16-cell phase, the 32-cell phase, and the 64-cell phase. ... Blastulation. ... A blastomere is the structure which results from the divisions of a fertilised egg during embryonic development . ... The hollow globe or sphere formed by the arrangement of the blastomeres on the periphery of an impregnated ovum. ... 1 - blastula, 2 - gastrula; orange - ectoderm, red - endoderm. ... 1 - blastula, 2 - gastrula; orange - ectoderm, red - endoderm. ... A Neurula is an embryo at the early stage of development in which neurulation occurs. ... Fetus at eight weeks Foetus redirects here. ...


General: Archenteron | Blastopore | Hensen's node | Germ layer (Ectoderm, Endoderm, Mesoderm) | Histogenesis | Organogenesis | Branchial arch (1st) | Meckel's cartilage | Somite/Somitomere | Thyroglossal duct | Vitelline duct The archenteron is an indentation that forms early on in a developing blastula. ... A blastopore is an opening into the archenteron during the embryonic stages of an organism. ... Hensens Node is the organizer for gastrulation in birds. ... It has been suggested that organogenesis be merged into this article or section. ... The ectoderm is outermost of the three germ layers of the developing embryo, the other two being the mesoderm and the endoderm. ... The endoderm, sometimes refered to as entoderm, is one of the three germ layers of the developing embryo, the other two being the ectoderm and the mesoderm. ... The mesoderm is one of the three germ layers in the early developing embryo, the other two layers being the ectoderm and the endoderm. ... An Introduction to Histogenesis Histogenesis is defined as the formation of tissues and organs from undifferentiated cells (Encarta Dictionary). ... Organogenesis is a stage of animal development where the ectoderm, endoderm, and mesoderm are formed. ... In the development of vertebrate animals, the branchial arches (or pharyngeal arches) develop during the fourth and fifth week in utero as a series of mesodermal outpouchings on the left and right sides of the developing pharynx. ... It has been suggested that this article or section be merged into branchial arch. ... The cartilaginous bar of the mandibular arch is formed by what are known as Meckel’s cartilages (right and left) ; above this the incus is developed. ... In the developing vertebrate embryo, somites are masses of mesoderm distributed along the two sides of the neural tube and that will eventually become dermis (dermatome), skeletal muscle (myotome), and vertebrae (sclerotome). ... In the developing vertebrate embryo, the somitomeres are loose masses of paraxial mesoderm derived cells that form along each side of the neural tube towards the end of the third gestational week. ... The thyroglossal duct is an embryological anatomical structure which forms the connection between the initial area of development of the thyroid gland and its final position. ... At the end of the fourth week the yolk-sac presents the appearance of a small pear-shaped vesicle (umbilical vesicle) opening into the digestive tube by a long narrow tube, the vitelline duct. ...


Circulatory system: Primitive atrium | Primitive ventricle | Bulbus cordis | Truncus arteriosus | Ostium primum | Foramen ovale | Ductus venosus | Ductus arteriosus | Aortic arches | Septum primum | Septum secundum | Cardinal veins Human circulatory system. ... The primitive atrium grows rapidly and partially encircles the bulbus cordis; the groove against which the bulbus cordis lies is the first indication of a division into right and left atria. ... The primitive ventricle becomes divided by a septum, the septum inferius or ventricular septum, which grows upward from the lower part of the ventricle, its position being indicated on the surface of the heart by a furrow. ... When the heart assumes its S-shaped form the bulbus cordis lies ventral to and in front of the primitive ventricle. ... For the medical condition with the same name, see Truncus arteriosus. ... In the developing heart, for a time the atria communicate with each other by an opening, the ostium primum of Born (interatrial foramen primum), below the free margin of the septum. ... In the fetal heart, the foramen ovale allows blood to enter the left atrium from the right atrium. ... In the fetus, the ductus venosus connects the left umbilical vein with the upper inferior vena cava. ... In the developing fetus, the ductus arteriosus (DA) is a shunt connecting the pulmonary artery to the aortic arch that allows much of the blood from the right ventricle to bypass the fetus fluid-filled lungs. ... This article focuses upon the multiple aortic arches present in the embryo. ... The cavity of the primitive atrium becomes subdivided into right and left chambers by a septum, the septum primum, which grows downward into the cavity. ... The septum secundum, semilunar in shape, grows downward from the upper wall of the atrium immediately to the right of the primary septum and foramen ovale. ... During development of the veins, the first indication of a parietal system consists in the appearance of two short transverse veins, the ducts of Cuvier, which open, one on either side, into the sinus venosus. ...


Nervous system: Neural development/Neurulation | Neural folds | Neural groove | Neural tube | Neural crest | Neuromere | Notochord | Optic vesicles | Optic stalk | Optic cup The nervous system of an animal coordinates the activity of the muscles, monitors the organs, constructs and also stops input from the senses, and initiates actions. ... The study of neural development draws on both neuroscience and developmental biology to describe the cellular and molecular mechanisms by which complex nervous systems emerge during embryonic development and throughout life. ... Neurulation is a part of organogenesis in vertebrate embryos. ... In front of the primitive streak two longitudinal ridges, caused by a folding up of the ectoderm, make their appearance, one on either side of the middle line. ... Between the neural folds is a shallow median groove, the neural groove. ... The neural tube is the embryonal structure that gives rise to the brain and spinal cord. ... The neural crest, a component of the ectoderm, is one of several ridgelike clusters of cells found on either side of the neural tube in vertebrate embryos. ... Neuromeres are transient segments during the early development of the human brain. ... The notochord is a flexible, rod-shaped body found in embryos of all chordates. ... The eyes begin to develop as a pair of diverticula from the lateral aspects of the forebrain. ... The optic vesicles project toward the sides of the head, and the peripheral part of each expands to form a hollow bulb, while the proximal part remains narrow and constitutes the optic stalk. ... The outer wall of the bulb of the optic vesicles becomes thickened and invaginated, and the bulb is thus converted into a cup, the optic cup (or ophthalmic cup), consisting of two strata of cells). ...


Digestive system: Foregut | Midgut | Hindgut | Proctodeum | Rathke's pouch | Septum transversum For the Physics term GUT, please refer to Grand unification theory The gastrointestinal or digestive tract, also referred to as the GI tract or the alimentary canal or the gut, is the system of organs within multicellular animals which takes in food, digests it to extract energy and nutrients, and... The foregut is the anterior part of the alimentary canal, from the mouth to the intestine, or to the entrance of the bile duct. ... The midgut is the portion of the embryo from which most of the intestines are derived. ... Hindgut is the posterior (caudal) part of the alimentary canal. ... A proctoduem is the back ectodermal part of an alimentary canal. ... The introduction to this article provides insufficient context for those unfamiliar with the subject matter. ... The liver arises in the form of a diverticulum or hollow outgrowth from the ventral surface of that portion of the gut which afterward becomes the descending part of the duodenum. ...


Urinary/Reproductive system: Urogenital folds | Urethral groove | Urogenital sinus | Kidney development (Pronephros | Mesonephros | Ureteric bud | Metanephric blastema) | Fetal genital development (Wolffian duct | Müllerian duct | Gubernaculum | Labioscrotal folds) The urinary system is the organ system that produces, stores, and carries urine. ... It has been suggested that this article or section be merged into sex organ. ... The urogenital folds are an embryological structure which give rise to a portion of the external genitalia. ... The urethral groove is a temporary linear indentation on the underside (ventral side) of the male penis during embryonic development. ... The urogenital sinus (also known as the persistent cloaca) is a part of the human body while it is an embryo. ... In humans, the metanephros (adult kidney) begins as an aggregate of mesenchymal cells that are detectable by the fifth gestational week as two small areas in the intermediate mesoderm close to the pelvic aorta. ... Pronephros the most primitive of the three excretory organs that develop in vertebrate, corresponding to the first stage of kidney development. ... The mesonephros (Latin for middle kidney) is one of three excretory organs that develop in vertebrates. ... The Ureteric bud is a portion of the mesonephric duct. ... The Metanephric blastema (or metanephric mesenchyme) is one of the two embryological structures that give rise to the kidney (the other is the ureteric bud. ... This article or section is in need of attention from an expert on the subject. ... The Wolffian duct (also known as archinephric duct, Leydigs duct, and the mesonephric duct) is an paired organ found in mammals including humans during embryogenesis. ... The Müllerian ducts are paired ducts of the embryo which empty into the cloaca, and which in the female develop into the upper vagina, cervix, uterus and oviducts; in the male they disappear except for the vestigial vagina masculina and the appendix testis. ... The gubernaculum is a fold of peritoneum which attaches to the caudal end of the testes. ... The labioscrotal folds (or labioscrotal swellings) are paired embryonic structures that represent the final stage of development of the caudal end of the external genitals before sexual differentiation. ...


Uterine support: Placenta | Umbilical cord (Umbilical artery, Umbilical vein, Wharton's jelly) | Amniotic sac (Amnion, Chorion) | Yolk sac | Allantois | Trophoblast (Cytotrophoblast | Syncytiotrophoblast | Gestational sac) The uterus or womb is the major female reproductive organ of most mammals, including humans. ... The placenta is an ephemeral (temporary) organ present only in female placental mammals during gestation (pregnancy). ... A newborn at 45 seconds. ... Umbilical arteries carry deoxygenated blood from the fetus to the placenta in the umbilical cord. ... Fetal circulation; the umbilical vein is the large, red vessel at the far left The umbilical vein is a blood vessel present during fetal development that carries oxygenated blood from the placenta to the growing fetus. ... Whartons jelly is a gelatinous substance within the umbilical cord. ... amniotic sac The amniotic sac is a tough but thin transparent pair of membranes, which hold a developing embryo (and later fetus) until shortly before birth. ... The amnion is a membranous sac which surrounds and protects the embryo. ... Chorion can refer to the following things: Chorion is the outer membrane of the amniotic sac. ... The yolk sac is the first element seen in the gestational sac during pregnancy, usually at 5 weeks gestation. ... Allantois is a part of a developing animal embryo. ... The trophoblast (from Greek threphein: to feed) is considered to be the first of all embryonic annexes. ... The introduction to this article provides insufficient context for those unfamiliar with the subject matter. ... Syncytiotrophoblasts are cells found in the placenta of human embryos. ... The gestational sac is the only available intrauterine structure that can be used to determine if an intrauterine pregnancy (IUP) exists, until the embryo is identified. ...


  Results from FactBites:
 
ASU SoLS Faculty: Robert W. McGaughey (537 words)
Past emphasis was on the cytogenetics and hormonal regulation of mammalian oocyte maturation and the influence of the cytoskeleton on fertilization, on cleavage and on early differentiation of trophectoderm in the mammalian embryo.
A role for intermediate filaments in the establishment of the primitive epithelia during mammalian embryogenesis.
Protein Kinase M, the cytosolic counterpart of protein kinase C remodels the internal cytoskeleton of the mammalian egg during activation.
Knocking the Sox off early mammalian development (491 words)
Scientists have identified a gene that is required during early mammalian embryogenesis to maintain cellular pluripotency – the ability of an embryonic cell to develop into virtually any cell type of the adult animal.
This discovery by Dr. Robin Lovell-Badge and colleagues at the MRC National Institute for Medical Research (London, UK) that the Sox2 gene is necessary to sustain the developmental plasticity of embryonic cells sheds new light on the molecular cues that direct early embryogenesis, as well as the genetic requirements for embryonic stem cell maintenance.
Lovell-Badge and colleagues show that Sox2 is actually expressed in a broader range than Oct4 in the embryo: While the expression of both genes is required in the ICM and epiblast, only Sox2 is also required to sustain multipotential cells derived from the trophoblast lineage.
  More results at FactBites »

 

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