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Encyclopedia > Mario Capecchi
Mario Capecchi

Born October 6, 1937 (1937-10-06) (age 70)
Flag of Italy Verona, Italy
Field Genetics
Institutions Harvard School of Medicine
University of Utah
Alma mater Antioch College, Ohio
Harvard University
Known for Knockout mouse
Notable prizes Albert Lasker Award for Basic Medical Research (2001)
Wolf Prize in Medicine (2002)
Nobel Prize in Physiology or Medicine (2007)

Mario Renato Capecchi (born 6 October 1937) is an Italian-born American molecular geneticist and a co-winner of the 2007 Nobel Prize in Physiology or Medicine.[1] He is currently Distinguished Professor of Human Genetics and Biology at the University of Utah School of Medicine. If you hold the copyright to an image (e. ... is the 279th day of the year (280th in leap years) in the Gregorian calendar. ... Year 1937 (MCMXXXVII) was a common year starting on Friday (link will display the full calendar) of the Gregorian calendar. ... Image File history File links Flag_of_Italy. ... This article is about the city in Italy. ... This article is about the general scientific term. ... Shield of Harvard Medical School Harvard Medical School (HMS) is one of the graduate schools of Harvard University. ... The University of Utah (also The U or the U of U or the UU), located in Salt Lake City, is the flagship public research university in the state of Utah, and one of 10 institutions that make up the Utah System of Higher Education. ... Antioch College is a private, independent liberal arts college in Yellow Springs, Ohio and is the founder and flagship institution of the six campus Antioch University system. ... Official language(s) English de facto Capital Columbus Largest city Columbus Largest metro area Greater Cleveland Area  Ranked 34th  - Total 44,825 sq mi (116,096 km²)  - Width 220 miles (355 km)  - Length 220 miles (355 km)  - % water 8. ... Harvard University (incorporated as The President and Fellows of Harvard College) is a private university in Cambridge, Massachusetts, USA and a member of the Ivy League. ... Knockout mice A knockout mouse is a genetically engineered mouse that has had one or more of its genes made inoperable through a gene knockout. ... The Albert Lasker Award for Basic Medical Research is awarded by the Lasker Foundation for the understanding, diagnosis, prevention, treatment, and cure of disease. ... Past winners of the Wolf Prize in Medicine: 1978 George D. Snell, Jean Dausset, Jon J. van Rood 1979 Roger W. Sperry, Arvid Carlsson, Oleh Hornykiewicz 1980 Cesar Milstein, Leo Sachs, Sir James L. Gowans 1981 Barbara McClintock, Stanley N. Cohen 1982 Jean-Pierre Changeux, Solomon H. Snyder, Sir James... Image File history File links Nobel_prize_medal. ... List of Nobel Prize laureates in Physiology or Medicine from 1901 to the present day. ... is the 279th day of the year (280th in leap years) in the Gregorian calendar. ... Year 1937 (MCMXXXVII) was a common year starting on Friday (link will display the full calendar) of the Gregorian calendar. ... A geneticist is a scientist who studies genetics, the science of heredity and variation of organisms. ... List of Nobel Prize laureates in Physiology or Medicine from 1901 to the present day. ... A karyotype of a human male, showing 46 chromosomes including XY sex chromosomes. ... Biology studies the variety of life (clockwise from top-left) E. coli, tree fern, gazelle, Goliath beetle Biology (from Greek: βίος, bio, life; and λόγος, logos, knowledge), also referred to as the biological sciences, is the study of living organisms utilizing the scientific method. ... The University of Utah (also The U or the U of U or the UU), located in Salt Lake City, is the flagship public research university in the state of Utah, and one of 10 institutions that make up the Utah System of Higher Education. ...

Contents

Early years

Mario Capecchi was born in the Italian city of Verona in 1937 to Luciano Capecchi [2], an Italian airman who would be later reported as missing in action while manning an anti-aircraft gun in Lybia[3], and Lucy Ramberg, an American-born[4] daughter of Impressionist painter Lucy Dodd Ramberg. During World War II, Mario Capecchi's mother was sent to the Dachau concentration camp[4][5] as punishment for belonging to an anti-Fascist group,[6] leaving the four-year-old Capecchi in the care of an Italian agricultural family[2] near Bolzano-Bozen[3]. Eventually, the family was unable to care for him, and he was left to fend for himself on the streets of Verona for the next four years.[3] Reunited with his mother after the war, he and mother moved to Philadelphia in the United States to live at a Quaker commune called "Bryn Gweled"[7] founded by Capecchi's maternal uncle, Edward Ramberg, [2] an American physicist at RCA. (Capecchi's other maternal uncle, Walter Ramberg, was also an American physicist who served as the tenth president of the Society for Experimental Stress Analysis. [8]) This article is about the city in Italy. ... “Flak” redirects here. ... The Western Desert Campaign was the primary early theatre of the North African Campaign of World War II. It is sometimes referred to as the Egypt-Libya Campaign. ... See also Impressionist (entertainment): A girl with a watering can by Renoir, 1876 Impressionism was a 19th century art movement, which began as a private association of Paris-based artists who exhibited publicly in 1874. ... Combatants Allied powers: China France Great Britain Soviet Union United States and others Axis powers: Germany Italy Japan and others Commanders Chiang Kai-shek Charles de Gaulle Winston Churchill Joseph Stalin Franklin Roosevelt Adolf Hitler Benito Mussolini Hideki Tōjō Casualties Military dead: 17,000,000 Civilian dead: 33,000... Germany Bayern  - coordinates , ,  - elevation 505 m (1,657 ft) 40,496 () Peter Bürgel CET (UTC+1)  -  CEST (UTC+2) 85221 Dachau (lower right) in Bavaria : www. ... Fascism (in Italian, fascismo), capitalized, was the authoritarian political movement which ruled Italy from 1922 to 1943 under the leadership of Benito Mussolini. ... Bolzano (Bozen) (Italian Bolzano; German: Bozen; Ladin: Bulsan; Latin: Bauzanum; Note that many of the regions Italian languages/dialects use Bolzan or Bulsan) is a city in the Trentino-Alto Adige/Südtirol region of Italy. ... For other uses, see Philadelphia (disambiguation) and Philly. ... The Religious Society of Friends, commonly known as Quakers, or Friends, is a religious community founded in England in the 17th century. ... Edward G. Ramberg (June 14, 1907 in Florence, Italy – January 9, 1995) was an American physicist who contributed to the early development of electron microscopy and color television. ... RCA, formerly an acronym for the Radio Corporation of America, is now a trademark owned by Thomson SA through RCA Trademark Management S.A., a company owned by Thomson. ...


Mario Capecchi received his B.S. in chemistry and physics in 1961 from Antioch College in Ohio. He received his Ph.D. in biophysics in 1967 from Harvard University with a doctoral thesis under the tutelage of James D. Watson. Capecchi was a Junior Fellow of the Society of Fellows at Harvard University from 1967 to 1969. In 1969 he became an Assistant Professor in the Department of Biochemistry at Harvard School of Medicine. He was promoted to Associate Professor in 1971. In 1973 he joined the faculty at the University of Utah. Since 1988 Capecchi has also been an investigator of the Howard Hughes Medical Institute. He is a member of the National Academy of Sciences. BS or bs is an abbreviation with multiple meanings, including: Bachelor of Science degree British Standard Bahamas (ISO country code) The postcode for Bristol, England A somewhat more polite abbreviation of bullshit A card game The Swiss canton of Basel_Stadt Shorthand for the backspace and the backspace control character Shorthand... For other uses, see Chemistry (disambiguation). ... A magnet levitating above a high-temperature superconductor demonstrates the Meissner effect. ... Antioch College is a private, independent liberal arts college in Yellow Springs, Ohio and is the founder and flagship institution of the six campus Antioch University system. ... Official language(s) English de facto Capital Columbus Largest city Columbus Largest metro area Greater Cleveland Area  Ranked 34th  - Total 44,825 sq mi (116,096 km²)  - Width 220 miles (355 km)  - Length 220 miles (355 km)  - % water 8. ... Doctor of Philosophy (Ph. ... Biophysics (also biological physics) is an interdisciplinary science that applies the theories and methods of physics, to questions of biology. ... Harvard University (incorporated as The President and Fellows of Harvard College) is a private university in Cambridge, Massachusetts, USA and a member of the Ivy League. ... James Dewey Watson (born April 6, 1928) is an American molecular biologist, best known as one of the co-discoverers of the structure of DNA. Watson, Francis Crick, and Maurice Wilkins were awarded the 1962 Nobel Prize for Physiology or Medicine for their discoveries concerning the molecular structure of nucleic... Biochemistry is the study of the chemical processes in living organisms. ... Shield of Harvard Medical School Harvard Medical School (HMS) is one of the graduate schools of Harvard University. ... The Howard Hughes Medical Institute (HHMI) is a United States non-profit medical research institute based in Chevy Chase, Maryland and originally founded by the aviator and engineer Howard Hughes in 1953. ... President Harding and the National Academy of Sciences at the White House, Washington, DC, April 1921 The National Academy of Sciences (NAS) is a corporation in the United States whose members serve pro bono as advisers to the nation on science, engineering, and medicine. ...


Knockout mice

Mario Capecchi is particularly well known for his pioneering work in gene targeting of the mouse embryo-derived stem cells which enabled other transgenic technologies including cloning and genetic modification. This work was accomplished through the efforts of Martin Evans and Oliver Smithies working on the knockout mice. This work was awarded 2007 Nobel prize for medicine or physiology. A genetically modified organism is an organism whose genetic material has been deliberately altered. ... For other uses, see clone. ... Sir Martin Evans is a British scientist, he is credited with discovering embryonic stem cells in 1981, and for the development of the knockout mouse Categories: Geneticists | Scientist stubs ... Oliver Smithies was awarded a Lasker Award in 2001. ... Knockout mice A knockout mouse is a genetically engineered mouse that has had one or more of its genes made inoperable through a gene knockout. ...


Dr. Capecchi has also pursued a systematic analysis of the mouse Hox gene family. This gene family plays a key role in the control of embryonic development in all multicellular animals.


Honours

Bristol-Myers Squibb NYSE: BMY, colloquially referred to as BMS, is a pharmaceutical corporation, formed by a 1989 merger between pharmaceutical companies Bristol-Myers Company and Squibb Corporation. ... The Gairdner Foundation is a non-profit organisation devoted to the recognition of outstanding achievement in biomedical research worldwide. ... The Albert Lasker Award for Basic Medical Research is awarded by the Lasker Foundation for the understanding, diagnosis, prevention, treatment, and cure of disease. ... The Gairdner Foundation International Award is given annually at a special dinner to three to six people for outstanding discoveries or contributions to medical science. ... General Motors Corporation (NYSE: GM), also known as GM, is an American automobile maker with worldwide operations and brands including Buick, Cadillac, Chevrolet, GMC, Holden, Hummer, Opel, Pontiac, Saturn, Saab and Vauxhall. ... Cover of Time Magazine (December 27, 1926) Alfred Pritchard Sloan, Jr. ... The Kyoto Prize (京都賞) has been awarded annually since 1984 by the Inamori Foundation, founded by Kazuo Inamori (fortune from ceramics). ... Feodor Felix Konrad Lynen (6. ... Horace Mann (May 4, 1796 – August 2, 1859) was an American education reformer and abolitionist. ... National Medal of Science The National Medal of Science is an honor given by the President of the United States to individuals in science and engineering who have made important contributions to the advancement of knowledge in the fields of behavioral and social sciences, biology, chemistry, engineering, mathematics and physics. ... Past winners of the Wolf Prize in Medicine: 1978 George D. Snell, Jean Dausset, Jon J. van Rood 1979 Roger W. Sperry, Arvid Carlsson, Oleh Hornykiewicz 1980 Cesar Milstein, Leo Sachs, Sir James L. Gowans 1981 Barbara McClintock, Stanley N. Cohen 1982 Jean-Pierre Changeux, Solomon H. Snyder, Sir James... March of Dimes official logo March of Dimes is the name of health charities in both the United States and Canada. ... List of Nobel Prize laureates in Physiology or Medicine from 1901 to the present day. ... Sir Martin Evans is a British scientist, he is credited with discovering embryonic stem cells in 1981, and for the development of the knockout mouse Categories: Geneticists | Scientist stubs ... Oliver Smithies was awarded a Lasker Award in 2001. ...

References

  1. ^ The Nobel Prize in Physiology or Medicine 2007. Nobelprize.org. Retrieved on 8 October 2007.
  2. ^ a b c Susan Sample (2007). Scientist Profile: Mario Capecchi. University of Utah.
  3. ^ a b c http://www.repubblica.it/2007/10/sezioni/scienza_e_tecnologia/nobel-medicina-2007/storia-capecchi/storia-capecchi.html
  4. ^ a b Lois M. Collins (2007-10-08). U. scientist Capecchi wins Nobel Prize. Deseret Morning News.
  5. ^ Karl Ritter and Matt Moore (2007-10-08). US, UK Scientists Win Nobel in Medicine. ABC News.
  6. ^ Troy Goodman (2007-10-08 (first published 2001-09-16). U. scientist Mario Cappechi scores a 'knockout'. Salt Lake Tribune.
  7. ^ American Philosophical Society. Edward G. Ramberg Papers. American Philosphical Society.
  8. ^ C.E. Taylor. A tribute to Walter Ramberg.
  9. ^ 2001 Albert Lasker Award for Basic Medical Research. Lasker Foundation. Retrieved on 1 October 2007.

The University of Utah (also The U or the U of U or the UU), located in Salt Lake City, is the flagship public research university in the state of Utah, and one of 10 institutions that make up the Utah System of Higher Education. ... The Deseret Morning News is a newspaper published in Salt Lake City, Utah, and Utahs oldest continually published daily newspaper. ... ABC News Special Report ident, circa 2006 ABC News is a division of American television and radio network ABC, owned by The Walt Disney Company. ... Marquis of the Salt Lake Tribune on the Tribune Building in Downtown Salt Lake City The Salt Lake Tribune is Salt Lake City, Utahs largest-circulated local daily newspaper. ...

External links

v • d • e
Nobel Prize in Physiology or Medicine Laureates

Leland H. Hartwell / Tim Hunt / Paul Nurse (2001) • Sydney Brenner / H. Robert Horvitz / John E. Sulston (2002) • Paul Lauterbur / Peter Mansfield (2003) • Richard Axel / Linda B. Buck (2004) • Barry Marshall / Robin Warren (2005) • Andrew Fire / Craig Mello (2006) • Mario Capecchi / Martin Evans / Oliver Smithies (2007) List of Nobel Prize laureates in Physiology or Medicine from 1901 to the present day. ... Winners of the Nobel Prize are scientists, writers and peacemakers who have been awarded in their field of endeavour, and who are known collectively as either Nobel laureates or Nobel Prize winners. ... Leland H. Hartwell (born October 30, 1939, in Los Angeles, California) is president and director of the Fred Hutchinson Cancer Research Center in Seattle, Washington. ... Dr. Richard Timothy (Tim) Hunt (b. ... Sir Paul M. Nurse, FRS, (b. ... To meet Wikipedias quality standards, this article or section may require cleanup. ... H. Robert Horvitz is an American biologist best known for his research on the nematode worm Caenorhabditis elegans. ... Sir John Edward Sulston PhD, FRS (born March 27, 1942) was educated at Pembroke College, Cambridge graduating in 1963. ... Paul Christian Lauterbur, (born May 6, 1929) is an American chemist who shared the Nobel Prize in Physiology or Medicine in 2003 with Peter Mansfield for his work which made the development of magnetic resonance imaging (MRI) possible. ... Sir Peter Mansfield, FRS, (born 9 October 1933), is a British physicist who was awarded the 2003 Nobel Prize in Physiology or Medicine for his discoveries concerning magnetic resonance imaging (MRI). ... Richard Axel, M.D. (born July 2, 1946, New York City) is an American scientist whose work on the olfactory system won him and Linda B. Buck, a former post-doctoral scientist in his research group, the Nobel Prize in Physiology or Medicine in 2004. ... Linda B. Buck, Ph. ... Barry James Marshall, FRS FAA (born 30 September 1951 in Kalgoorlie, Western Australia) is an Australian physician and Professor of Clinical Microbiology at the University of Western Australia. ... J. Robin Warren (born June 11, 1937 in Adelaide) is an Australian pathologist and researcher who is credited with the 1979 discovery of the bacterium Helicobacter pylori. ... Andrew Z. Fire Andrew Zachary Fire (born on April 27th 1959) is an American professor of pathology and of genetics at the Stanford University School of Medicine. ... Craig C. Mello, PhD Craig Cameron Mello (born October 18, 1960 in New Haven, Connecticut) is one of the laureates of the 2006 Nobel Prize for Physiology or Medicine, along with Andrew Z. Fire, for the discovery of RNA interference. ... Sir Martin Evans is a British scientist, he is credited with discovering embryonic stem cells in 1981, and for the development of the knockout mouse Categories: Geneticists | Scientist stubs ... Oliver Smithies was awarded a Lasker Award in 2001. ...

Complete roster | (1901-1925) | (1926-1950) | (1951-1975) | (1976-2000) | (2001-2025)
v • d • e
Wolf Prize in Medicine Laureates

George Snell / Jean Dausset / Jon J. van Rood (1978) • Roger Sperry / Arvid Carlsson / Oleh Hornykiewicz (1979) • César Milstein / Leo Sachs / James L. Gowans (1980) • Barbara McClintock / Stanley Norman Cohen (1981) • Jean-Pierre Changeux / Solomon H. Snyder / James W. Black (1982) • Donald F. Steiner (1984) • Osamu Hayaishi (1986) • Pedro Cuatrecasas / Meir Wilchek (1987) • Henri G. Hers / Elizabeth F. Neufeld (1988) • John Gurdon / Edward B. Lewis (1989) • Maclyn McCarty (1990) • Seymour Benzer (1991) • Judah Folkman (1992) • Michael Berridge / Yasutomi Nishizuka (1994) • Stanley B. Prusiner (1995) • Mary F. Lyon (1997) • Michael Sela / Ruth Arnon (1998) • Eric Kandel (1999) • Avram Hershko / Alexander Varshavsky (2001) • Ralph L. Brinster / Mario Capecchi / Oliver Smithies (2002) • Robert Weinberg / Roger Y. Tsien (2004) • Alexander Levitzki / Anthony R. Hunter / Anthony Pawson (2005) Past winners of the Wolf Prize in Medicine: 1978 George D. Snell, Jean Dausset, Jon J. van Rood 1979 Roger W. Sperry, Arvid Carlsson, Oleh Hornykiewicz 1980 Cesar Milstein, Leo Sachs, Sir James L. Gowans 1981 Barbara McClintock, Stanley N. Cohen 1982 Jean-Pierre Changeux, Solomon H. Snyder, Sir James... George Davis Snell (December 19, 1903 – June 6, 1996) was a U.S. geneticist and co-recipient of the 1980 Nobel Prize in Physiology or Medicine, together with Baruj Benacerraf and Jean Dausset, for discovery of the Major histocompatibility complex genes which encode cell surface molecules important for the immune... Jean Dausset (b. ... Image:Roger W Sperry. ... Arvid Carlsson (b. ... César Milstein (October 8, 1927 – March 24, 2002) was an Argentine-born scientist who spent most of his life in Great Britain. ... Leo Sachs (born 1924) is a German-born Israeli molecular biologist and cancer researcher. ... Barbara McClintock (June 16, 1902 – September 2, 1992) was a pioneering American scientist and one of the worlds most distinguished cytogeneticists. ... Stanley Norman Cohen is an American geneticist. ... Jean-Pierre Changeux (born in Domont, France, April 7, 1936) is a French neuroscientist, who researched many different areas of biology in his life, from the structure and function of proteins, to the early development of the nervous system. ... Dr. Solomon Snyder (born December 26, 1938) is an American neuroscientist. ... Sir James Whyte Black, OM, FRS, FRSE, FRCP (born 14 July 1924) is a Scottish pharmacologist who invented Propranolol, synthesized Cimetidine and was awarded the Nobel Prize for Medicine in 1988 for these discoveries. ... Donald F. Steiner (1930) is an American biochemist and a professor at the University of Chicago. ... Osamu Hayaishi ) (born 1920) is a Japanese biologist and a professor at Osaka Biocience Institute. ... Pedro Cuatrecasas (1936) is an American biochemist and an Adjunct Professor of Pharmacology & Medicine at the University of California, San Diego. ... Meir Wilchek (1935) is a professor at the Weizmann Institute of Science. ... Henri-Géry Hers (born 1923) is a Belgian physiologist and biochemist, and he was a professor at the Universite Catholique de Louvain. ... Elizabeth F. Neufeld (b. ... John Gurdon is a controversial British biologist. ... Edward B. Lewis (May 20, 1918 – July 21, 2004) was an American geneticist, the winner of the 1995 Nobel Prize in Medicine. ... Maclyn McCarty (June 9, 1911–January 2, 2005) was an American geneticist. ... Seymour Benzer (born October 15, 1921) is an accomplished American physicist and biologist. ... Dr. Judah Folkman (b. ... Sir Michael John Berridge FRS (born October 22, 1938) is a British biologist. ... Yasutomi Nishizuka (1932-2004) is a Japanese biologist who found protein kinasse C (PKC) and made important contribution to the understanding of molecular mechanism of signal transduction across the cell membrane. ... Stanley Ben Prusiner (born May 28, 1942[1]) is an American neurologist and biochemist. ... Mary Francis Lyon (b. ... Michael Sela (1924-) is the W. Garfield Weston Professor of Immunology at the Weizmann Institute of Science. ... Ruth Arnon is an Israeli biochemsit and codeveloper of the multiple schlerosis drug Copaxone. ... Eric Richard Kandel (born November 7, 1929) is a neuroscientist who won a Nobel Prize in the year 2000 for his research on the physiological basis of memory storage in neurons. ... Avram Hershko (‎, born Herskó Ferenc, 31 December 1937) is an Israeli biologist. ... Alexander Varshavsky is a Russian American biochemist and recipient of the Albert Lasker Award for Basic Medical Research, the Wolf Prize in Medicine and the Louisa Gross Horwitz Prize for his research on ubiquitination. ... Ralph L. Brinster (1932) is an American veterinarian and Richard J. Mellon Professor of Reproductive Physiology at the School of Veterinary Medicine, University of Pennsylvania. ... Oliver Smithies was awarded a Lasker Award in 2001. ... Category: ... Roger Yonchien Tsien (1952-) is an American chemist and a professor at the Department of Chemistry and Biochemistry, University of California, San Diego. ... Alexander Levitzki (1940-) is an Israeli biochemist who is a Professor of Biochemistry at the Hebrew University of Jerusalem. ... Anthony R. Hunter (b. ... Dr. Anthony James Pawson Anthony James Pawson, O.C., Ph. ...

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  Results from FactBites:
 
Eccles Institute of Human Genetics - Mario R. Capecchi (1195 words)
Economides KR and Capecchi MR (2003) Hoxb13 is required for normal differentiation and secretory function of the ventral prostate.
Economides KD, Zeltser L and Capecchi MR (2003) Hoxb13 mutations cause overgrowth of caudal spinal cord and tail vertebrae.
Barrow JR, Stadler HS and Capecchi MR (2000) Roles of Hoxa1 and Hoxa2 in patterning the early hindbrain of the mouse.
Mario Capecchi Summary (725 words)
Capecchi was born in Verona, Italy in 1937.
Mario Capecchi is a professor of human genetics and adjunct professor of cellular, viral, and molecular biology at the University of Utah School of Medicine and professor of biology at the University of Utah.
Mario Capecchi is particularly well known for his pioneering work in gene targeting of the mouse embryo-derived stem cells which enabled other transgenic technologies including cloning and genetic modification.
  More results at FactBites »


 

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