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Encyclopedia > Martha Chase

Martha Cowles Chase (19272003) was a young laboratory assistant in the early 1950s when she and Alfred Hershey conducted one of the most famous experiments in 20th century biology. Devised by American bacteriophage expert Alfred Hershey at Cold Spring Harbor Laboratory New York, the famous experiment demonstrated the genetic properties of DNA over proteins. By marking bacteriophages with radioactive isotopes, Hershey and Chase were able to trace protein and DNA to determine which is the molecule of heredity. Martha is funny and likes to eat dogs. (and cats) 1927 (MCMXXVII) was a common year starting on Saturday (link will take you to calendar). ... 2003 (MMIII) was a common year starting on Wednesday of the Gregorian calendar. ... Biology (from Greek Βìο meaning life and Λoγος meaning the study of, see below) is the study of life. ... This article or section does not cite its references or sources. ... Alfred Day Hershey (December 4, 1908 – May 22, 1997) was an American Nobel Prize-winning bacteriologist. ... The Cold Spring Harbor Laboratory (CSHL) is a research and educational institution, consisting of science laboratories located in Cold Spring Harbor, New York on Long Island, USA. The Laboratory has research programs focusing on cancer, neurobiology, plant genetics, genomics and bioinformatics, and has a broad educational mission, including the recently... The Hershey-Chase experiment was a series of experiments conducted in 1952 by Alfred Hershey and Martha Chase that identified DNA to be the genetic material of phages and, ultimately, of all organisms. ... For a non-technical introduction to the topic, please see Introduction to genetics. ... The structure of part of a DNA double helix. ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... A radionuclide is an atom with an unstable nucleus. ... Heredity (the adjective is hereditary) is the transfer of characteristics from parent to offspring, either through their genes or through the social institution called inheritance (for example, a title of nobility is passed from individual to individual according to relevant customs and/or laws). ...


Hershey and Chase announced their results in a 1952 paper. The experiment inspired American researcher James D. Watson, who along with England's Francis Crick figured out the structure of DNA at the Cavendish Laboratory of the University of Cambridge the following year. 1952 (MCMLII) was a Leap year starting on Tuesday (link will take you to calendar). ... James Dewey Watson KBE(Hon) ForMemRS (born April 6, 1928) is an American scientist, best known as one of the four discoverers of the structure of the DNA molecule. ... Francis Harry Compton Crick OM (8 June 1916 – 28 July 2004) was an English physicist, molecular biologist and neuroscientist, most noted for being one of the co-discoverers of the structure of the DNA molecule in 1953. ... Plaque, at old site The Cavendish Laboratory is the University of Cambridges Department of Physics, and is part of the universitys School of Physical Sciences. ... The University of Cambridge, located in Cambridge, England, is the second-oldest university in the English-speaking world, with a reputation as one of the worlds most prestigious universities. ...


Hershey shared the 1969 Nobel Prize in Physiology or Medicine with Salvador Luria and Max Delbrück. Chase, however, did not reap such rewards for her role. A graduate of The College of Wooster in Ohio (she had grown up in Shaker Heights, Ohio), she continued working as a laboratory assistant, first at the Oak Ridge National Laboratory in Tennessee and then at the University of Rochester before moving to Los Angeles in the late 1950s. There she married and earned her Ph.D. in 1964 from the University of Southern California. A series of personal setbacks through the 1960s ended her career in science. She spent decades suffering from a form of dementia that robbed her of short-term memory. She died on August 8, 2003. Year 1969 (MCMLXIX) was a common year starting on Wednesday (the link is to a full 1969 calendar). ... List of Nobel Prize laureates in Physiology or Medicine from 1901 to the present day. ... Salvador Edward Luria (August 13, 1912 – February 6, 1991) was an American microbiologist whose pioneering work on phages helped open up molecular biology. ... Max Delbrück (September 4, 1906 - March 9, 1981) was a German biologist. ... The College of Wooster is a residential liberal arts college primarily known for its Independent Study program. ... Official language(s) None Capital Columbus Largest city Columbus Largest metro area Cleveland Area  Ranked 34th  - Total 44,825 sq mi (116,096 km²)  - Width 220 miles (355 km)  - Length 220 miles (355 km)  - % water 8. ... Shaker Heights is a city in Cuyahoga County, Ohio, United States. ... A combination of federal, state and private funds is providing $300 million for the construction of 13 facilities on ORNLs new main campus. ... Official language(s) English Capital Nashville Largest city Memphis Largest metro area Nashville Area  Ranked 36th  - Total 42,169 sq mi (109,247 km²)  - Width 120 miles (195 km)  - Length 440 miles (710 km)  - % water 2. ... The University of Rochester is a private, coeducational and nonsectarian research institution located in Rochester, New York. ... Nickname: City of Angels Location within Los Angeles County in the state of California Coordinates: State California County Los Angeles County Mayor Antonio Villaraigosa Area    - City 1,290. ... 1964 (MCMLXIV) was a leap year starting on Wednesday (the link is to a full 1964 calendar). ... The University of Southern California (commonly referred to as USC, SC, Southern California, and incorrectly as Southern Cal[1]), located in the University Park neighborhood in Los Angeles, California, USA, was founded in 1880, making it Californias oldest private research university. ... Dementia (from Latin de- apart, away + mens (genitive mentis) mind) is the progressive decline in cognitive function due to damage or disease in the brain beyond what might be expected from normal aging. ...


Her works include:

  • Independent Functions of Viral Protein and Nucleic Acid in Growth of Bacteriophage, September 20, 1952

  Results from FactBites:
 
Martha Cowles Chase Biography | World of Microbiology and Immunology (633 words)
This was a critical period in the history of modern genetics and the beginning of an entirely new phase of research that established the science of molecular biology.
Thus, it is remarkable that Martha Chase's name is inextricably linked to all accounts of the path to the demonstration that DNA is the genetic material.
Hershey and Chase found that most of the bacteriophage DNA remained with the bacterial cells while their protein coats were released into the medium.
The Scientist : Martha Chase dies (854 words)
Martha Chase, renowned for her part in the pivotal "blender experiment," which firmly established DNA as the substance that transmits genetic information, died of pneumonia on August 8 in Lorain, Ohio.
In 1952, Chase participated in what came to be known as the Hershey-Chase experiment in her capacity as a laboratory assistant to Alfred D. Hershey.
Chase, who was born and raised in Cleveland Heights, Ohio, is survived by her sister Ruth Daziel of Milford, Conn. Martha Chase liked to travel and visited many of the national parks, Daziel recalled.
  More results at FactBites »


 

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