Mayo Methot (March 3, 1904 - June 9, 1951) was an American film and theater actress.

Methot was born in Portland, Oregon. A petite brunette, she became a popular actress on Broadway during the 1920s where she was admired for both her acting and singing ability. She moved to Hollywood in the early 1930s and began an association with Warner Brothers Studios. She found herself most usually cast as unsympathetic second leads, and tough talking "dames" of Warner's contemporary crime melodramas. It was during the filming of one such film Marked Woman, that Methot met Humphrey Bogart. They married in 1938.

The couple became high profile Hollywood celebrities, but it was not a smooth marriage. Both Bogarts drank heavily, and Methot gained a reputation for her violent excesses when under the influence of alcohol. They became known as "The Battling Bogarts". Actress Gloria Stuart recalled in her later years, a dinner party at which Methot produced a pistol and threatened to shoot Bogart. Methot's career went into a rapid decline as a result of her drinking, and her marriage to Bogart ended in 1945, when he left her to marry Lauren Bacall.

Methot was unable to renew her career and settled into a pattern of alcoholism and depression. Struggling to support herself and ill from years of alcoholism, she died in a motel room in Multhomak, Oregon.