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Encyclopedia > Megaloblastic anemia
Megaloblastic anemia
Classification & external resources
Image:Megaloblastic anemia.jpg
Megaloblastic anemia blood smear
ICD-10 D51.1, D52.0, D53.1
ICD-9 281
DiseasesDB 29507
eMedicine med/1420  ped/2575
MeSH D000749

Megaloblastic anemia is an anemia (of macrocytic classification) which results from a deficiency of vitamin B12 and folic acid. It can be the result of a lack of intrinsic factor. The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ... The International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) is a coding of diseases and signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or diseases, as classified by the World Health Organization (WHO). ... // C00-D48 - Neoplasms (C00-C14) Malignant neoplasms, lip, oral cavity and pharynx (C00) Malignant neoplasm of lip (C01) Malignant neoplasm of base of tongue (C02) Malignant neoplasm of other and unspecified parts of tongue (C03) Malignant neoplasm of gum (C04) Malignant neoplasm of floor of mouth (C05) Malignant neoplasm of... // C00-D48 - Neoplasms (C00-C14) Malignant neoplasms, lip, oral cavity and pharynx (C00) Malignant neoplasm of lip (C01) Malignant neoplasm of base of tongue (C02) Malignant neoplasm of other and unspecified parts of tongue (C03) Malignant neoplasm of gum (C04) Malignant neoplasm of floor of mouth (C05) Malignant neoplasm of... // C00-D48 - Neoplasms (C00-C14) Malignant neoplasms, lip, oral cavity and pharynx (C00) Malignant neoplasm of lip (C01) Malignant neoplasm of base of tongue (C02) Malignant neoplasm of other and unspecified parts of tongue (C03) Malignant neoplasm of gum (C04) Malignant neoplasm of floor of mouth (C05) Malignant neoplasm of... The International Statistical Classification of Diseases and Related Health Problems (most commonly known by the abbreviation ICD) provides codes to classify diseases and a wide variety of signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or disease. ... The following is a list of codes for International Statistical Classification of Diseases and Related Health Problems. ... The Disease Bold textDatabase is a free website that provides information about the relationships between medical conditions, symptoms, and medications. ... eMedicine is an online clinical medical knowledge base that was founded in 1996. ... Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ... Anemia (AmE) or anæmia (BrE), from the Greek () meaning without blood, is a deficiency of red blood cells (RBCs) and/or hemoglobin. ... Cobalamin or vitamin B12 is a chemical compound that is also known as cyanocobalamine. ... Folic acid and folate (the anion form) are forms of the water-soluble Vitamin B9. ... Intrinsic factor is a glycoprotein produced by the parietal cells of the stomach. ...


It is characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrow; associated with pernicious anemia An erythroblast is a type of red blood cell which still retains a cell nucleus. ...


Causes

  • nutritional defects (folic acid or vitamin B12 which is mainly from animal sources; vegans may require supplementation)
  • chronic liver diseases
  • alcoholism
  • pregnancy
  • decreased production of intrinsic factor (this disease entity is called pernicious anemia)
  • intestinal malabsorption (due to an enteritis, celiac disease or other causes).
  • fish tapeworm infestation (Diphyllobothrium latum)
  • failure to replicate chromosomes due to lack of thymidine.
  • Lesch-Nyhan Syndrome
  • cytotoxic drugs interfering with DNA synthesis
  • intestinal flora disruption due to antibiotic use

Hens kept in cramped conditions — the avoidance of animal suffering is the primary motivation of people who become vegans A vegan is a person who avoids the ingestion or use of animal products. ... Intrinsic factor is a glycoprotein produced by the parietal cells of the stomach. ... I think this is cool Pernicious anemia is loosely used to mean a state of anemia due to vitamin B12 deficiency. ... Malabsorption is the state of impaired absorption of nutrients in the small intestine. ... Coeliac disease (also termed non-tropical sprue, celiac disease and gluten intolerance) is an autoimmune disease characterised by chronic inflammation of the proximal portion of the small intestine caused by exposure to certain dietary gluten proteins. ... Species Diphyllobothriasis is caused by the infestation of tapeworms, of the genus Diphyllobothrium. ... This article is about the biological chromosome. ... The chemical structure of deoxythymidine Thymidine (more precisely called deoxythymidine can also be labelled deoxyribosylthymine, and thymine deoxyriboside) is a chemical compound, more precisely a pyrimidine deoxynucleoside. ... -1...

Hematological findings

The blood film can point towards vitamin deficiency: Blood films, Giemsa stained A blood film or peripheral blood smear is a slide made from a drop of blood, that allows the cells to be examined. ...


Blood chemistries will also show: Human red blood cells Red blood cells are the most common type of blood cell and the vertebrate bodys principal means of delivering oxygen from the lungs or gills to body tissues via the blood. ... Structure of hemoglobin. ... The mean corpuscular volume, or MCV, is a measure of the average red blood cell volume (i. ... The mean corpuscular hemoglobin concentration, or MCHC, is a measure of the concentration of hemoglobin in a red blood cell. ... Reticulocyte Erythrocyte Reticulocytes are immature red blood cells, typically comprising about 1% of the red cells in the human body. ... A 250 ml bag of newly collected platelets. ... This article does not cite any references or sources. ... Anisocytosis is a medical term meaning that a patients red blood cells are of unequal size. ... Poikilocytosis is an increase in the number of abnormally shaped red blood cells as seen on a blood film. ... Grays Anatomy illustration of cells in bone marrow. ... Hyperplasia (or hypergenesis) is a general term for an increase in the number of the cells of an organ or tissue causing it to increase in size. ... Howell-Jolly bodies are histopathological findings of basophilic nuclear remnants (clusters of DNA) in young erythrocytes during the response to severe hemolytic anemia, megaloblastic anemia, splenectomy, or due to a damaged spleen. ...

  • Increased homocysteine and methylmalonic acid in B12 deficiency
  • Increased homocysteine in folate defiency

Analysis

The Schilling test is often performed to determine the nature of the vitamin B12 deficiency. The Schilling test is a medical investigation used in people with vitamin B12 deficiency. ...


  Results from FactBites:
 
Anemia - Wikipedia, the free encyclopedia (2292 words)
In older patients, iron deficiency anemia is often due to bleeding lesions of the gastrointestinal tract; fecal occult blood testing, upper endoscopy and lower endoscopy are often performed to identify bleeding lesions, which can be malignant.
Megaloblastic anemia due to a deficiency of either vitamin B12 or folic acid (or both) due either to inadequate intake or insufficient absorption.
The cause of megaloblastic anemia is primarily a failure of DNA synthesis with preserved RNA synthesis, which result in restricted cell division of the progenitor cells.
Diagnose-Me: Condition: Megaloblastic Anemia / Pernicious Anemia (3587 words)
Megaloblastic anemias are somewhat rare blood disorders characterized by the presence of large, structurally and visually abnormal, immature red blood cells (megaloblasts).
Megaloblastic anemias are usually caused by a deficiency or defective absorption of either vitamin B12 (cobalamin) or folic acid.
Pernicious anemia usually does not appear before the age of 30, although a juvenile form of the disease can occur in children and is evident before the child is 3 years old.
  More results at FactBites »


 

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