 | | Methylnaltrexone | | Systematic (IUPAC) name | | 17-(Cyclopropylmethyl)-17-methyl-4,5-epoxy-3,14-dihydroxymorphinanium-6-one | | Identifiers | | CAS number | 83387-25-1 | | ATC code | ? | | PubChem | 5361918 | | Chemical data | | Formula | C21H26NO4 | | Mol. mass | 356.44 g/mol | | Synonyms | Methylnaltrexone | | Pharmacokinetic data | | Bioavailability | ? | | Metabolism | ? | | Half life | ? | | Excretion | ? | | Therapeutic considerations | | Pregnancy cat. | ? IUPAC nomenclature is a system of naming chemical compounds and of describing the science of chemistry in general. ...
CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences, mixtures and alloys. ...
The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ...
PubChem is a database of chemical molecules. ...
A chemical formula is a concise way of expressing information about the atoms that constitute a particular chemical compound. ...
For other uses, see Carbon (disambiguation). ...
This article is about the chemistry of hydrogen. ...
General Name, symbol, number nitrogen, N, 7 Chemical series nonmetals Group, period, block 15, 2, p Appearance colorless gas Standard atomic weight 14. ...
General Name, symbol, number oxygen, O, 8 Chemical series nonmetals, chalcogens Group, period, block 16, 2, p Appearance colorless (gas) pale blue (liquid) Standard atomic weight 15. ...
The molecular mass (abbreviated Mr) of a substance, formerly also called molecular weight and abbreviated as MW, is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ...
Synonyms (in ancient Greek, ÏÏ
ν (syn) = plus and Ïνομα (onoma) = name) are different words with similar or identical meanings. ...
In pharmacology, bioavailability is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ...
Drug metabolism is the metabolism of drugs, their biochemical modification or degradation, usually through specialized enzymatic systems. ...
The biological half-life of a substance is the time required for half of that substance to be removed from an organism by either a physical or a chemical process. ...
The kidneys are important excretory organs in vertebrates. ...
The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...
| | Legal status | | | Routes | ? | Methylnaltrexone (MTNX) is one of the newer agents of peripherally-acting μ-opioid antagonists that act to reverse some of the side effects of opioid drugs such as constipation without affecting analgesia or precipitating withdrawals. Because it contains a permanently charged tetravalent nitrogen atom, it cannot cross the blood-brain barrier, and so has antagonist effects throughout the body, counteracting effects such as itching and constipation, but without affecting opioid effects in the brain such as analgesia. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ...
In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body. ...
The μ opioid receptors (MOR) are a class of opioid receptors with high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. ...
Antagonists will block the binding of an agonist at a receptor molecule, inhibiting the signal produced by a receptor-agonist coupling. ...
An opioid is a chemical substance that has a morphine-like action in the body. ...
Constipation or irregularity, is a condition of the digestive system where a person (or animal) experiences hard feces that are difficult to egest; it may be extremely painful, and in severe cases (fecal impaction) lead to symptoms of bowel obstruction. ...
For other uses of painkiller, see painkiller (disambiguation) An analgesic (colloquially known as painkiller) is any member of the diverse group of drugs used to relieve pain. ...
Withdrawal, also known as withdrawal syndrome, refers to the characteristic signs and symptoms that appear when a drug that causes physical dependence is regularly used for a long time and then suddenly discontinued or decreased in dosage. ...
The blood-brain barrier (BBB) is a membranic structure that acts primarily to protect the brain from chemicals in the blood, while still allowing essential metabolic function. ...
An itch (Latin: pruritus) is a sensation felt on an area of skin that makes a person or animal want to scratch it. ...
Development In December of 2005, Wyeth and Progenics entered into an exclusive, worldwide agreement for the joint development and commercialization of methylnaltrexone for the treatment of opioid-induced side effects, including constipation and post-operative ileus (POI), a prolonged dysfunction of the gastrointestinal (GI) tract following surgery. Under the terms of the agreement, the companies are collaborating on worldwide development. Wyeth received worldwide rights to commercialize methylnaltrexone, and Progenics retained an option to co-promote the product in the United States. Wyeth will pay Progenics royalties on worldwide sales and co-promotion fees within the United States. Ileus, formerly called iliac passion, refers to limited or absent intestinal passage. ...
Methylnaltrexone is being developed in subcutaneous and oral forms to treat opioid induced constipation (OIC) and an intravenous form for POI. Progenics and Wyeth are conducting two global phase 3 clinical trials in POI, targeting an NDA submission in this indication in early 2008. An oral formulation for OIC in patients with chronic pain currently is under development with an anticipated NDA submission in late 2009 or early 2010.
References - Holzer P (2007). "Treatment of opioid-induced gut dysfunction". Expert Opin Investig Drugs 16 (2): 181-94. PMID 17243938.
| Opioids | | Opiate derivatives | 6-methyldihydromorphine • 6-Methylenedihydrodesoxymorphine • Acetyldihydrocodeine • Acetyldihydrocodeinone • Acetylmorphone • Benzylmorphine • β-4-morpholinylethylmorphine • Codeine • Codeine-N-Oxide • Codeinone • Codoxime • Desomorphine • Diacetyldihydromorphine • Dihydrocodeine • Dihydrocodeinone enol acetate • Dihydrohydroxycodeinone • Dihydrodesoxymorphine • Dihydroheroin • Dihydroisocodeine • Dihydromorphine • Dipropanoylmorphine • Ethylmorphine • Heroin (Diamorphine) • Heterocodeine • Hydrocodone • Hydromorphinol • Hydromorphone • Laudanum • Methyldesorphine • Methyldihydromorphine • Methylnaltrexone • Metopon • Monoacetylmorphine • Morphine-N-Oxide • Morphine • Morphinone • Morphine-6-glucuronide • Myrophine • Nalbuphine • Nalmefene • Nalorphine • Naloxone • Naltrexone • Naltrindole • Nicocodeine • Nicodicodeine • Nicomorphine • Norcodeine • Normorphine • Omnopon • Opium • Oripavine • Oxycodone • Oxymorphone • Pantopon • Papaveretum • Paregoric • Pholcodeine • Pseudomorphine • Semorphone • Tetrapon • Thebacon • Thebaine An opioid is a chemical substance that has a morphine-like action in the body. ...
Scoring the poppy pod. ...
6-Methylenedihydrodesoxymorphine (6-MDDM) is an opiate analogue that is a derivative of hydromorphone, where the 6-ketone group has been replaced by methylene. ...
Acetyldihydrocodeine is an opiate derivative developed as a cough suppressant and analgesic. ...
This article or section does not adequately cite its references or sources. ...
Acetylmorphone (Dihydromorphinone acetate) is an opiate analogue that is an acetylated derivative of hydromorphone which was developed in the early 1900s as a potential cough suppressant and analgesic. ...
This article needs additional references or sources to facilitate its verification. ...
Codeine (INN) or methylmorphine is an opiate used for its analgesic, antitussive and antidiarrheal properties. ...
Codeinone is a strong Opiod. ...
Diacetyldihydromorphine (Paralaudin, Dihydroheroin) is a potent opiate derivative which is rarely used in some countries for the treatment of strong pain such as that caused by terminal cancer, as a more potent form of diamorphine. ...
Dihydrocodeine, also called DHC, Drocode, Paracodeine and Parzone and by the brand names of Synalgos DC, Panlor DC, Panlor SS, SS Bron, Drocode, Paracodin, Codidol, Didor Continus, Dicogesic, Codhydrine, Dekacodin, DH-Codeine, Didrate, Dihydrin, Hydrocodin, Nadeine, Novicodin, Rapacodin, Fortuss, Dico, and DF-118 amongst others, is a semi-synthetic opioid...
The chemical structure of dihydrocodeinone enol acetate Dihydrocodeinone Enol Acetate, or Thebacon, formerly marketed as its hydrochloride salt under the trade name Acedicon, is a semisynthetic opioid once used as an antitussive, primarily in Europe. ...
Not to be confused with oxytocin. ...
Diacetyldihydromorphine (Paralaudin, Dihydroheroin) is a potent opiate derivative developed in Germany in 1929 which is rarely used in some countries for the treatment of strong pain such as that caused by terminal cancer, as a more potent form of diamorphine. ...
Dihydromorphine is a semi-synthetic opioid invented in Germany in the first years of the twentieth century. ...
Dipropanoylmorphine is the 3,6-dipropanoyl ester of morphine, CAS number 10589-79-4. ...
Ethylmorphine is a drug in the class of both opiates (representing a minor synthetic change from morphine) and opioids (being effective in the CNSs opioid reception system) . Its effects in humans mainly stem from its metabolic conversion to morphine. ...
For other uses, see Heroin (disambiguation). ...
Heterocodeine (6-methylmorphine) is an opiate derivative, the 6-methyl ether of morphine, and a structural isomer of codeine. ...
Hydrocodone or dihydrocodeinone (marketed as Vicodin, Anexsia, Dicodid, Hycodan (or generically Hydromet), Hycomine, Lorcet, Lortab, Norco, Novahistex, Hydroco, Tussionex, Vicoprofen, Xodol) is a semi-synthetic opioid derived from two of the naturally occurring opiates, codeine and thebaine. ...
Hydromorphone is a drug developed in Germany in the 1920s and introduced to the mass market beginning in 1926. ...
This article is about the medicine. ...
Metopon (5-methylhydromorphone hydrochloride) is an opiate analogue that is a methylated derivative of hydromorphone which was invented in 1948 as an analgesic. ...
6-monoacetylmorphine (6-MAM) is one of 2 active metabolites of heroin (diacetylmorphine), the other being the much less active 3-monoacetylmorphine (3-MAM). ...
This article is about the drug. ...
Morphinone is a very strong Opiod. ...
Morphine-6-glucuronide (M6G) is of more than simply academic interest, since it is the major active metabolite of morphine, and as such is the molecule responsible for much of the pain-relieving effects of morphine (and heroin and codeine). ...
Nalbuphine (nalbuphine hydrochloride) is a synthetic opioid used commercially as an analgesic under a variety of trade names, including Nubain. ...
Nalmefene (Revex) is an opioid receptor antagonist used primarily in the management of alcohol dependence, and also has been investigated for the treatment of other addictions such as pathological gambling and addiction to shopping. ...
Nalorphine (INN, also known as N-allyl-normorphine) is a narcotic antagonist. ...
Naloxone is a drug used to counter the effects of opioid overdose, for example heroin and morphine overdose. ...
Naltrexone is an opioid receptor antagonist used primarily in the management of alcohol dependence and opioid dependence. ...
Nicocodeine (Lyopect) is an opiate derivative developed as a cough suppressant and analgesic. ...
Nicodicodeine is an opiate derivative developed as a cough suppressant and analgesic. ...
Nicomorphine (Vilan) is the 3,6-dinicotinate ester of morphine. ...
Papaveretum (BAN) is a preparation containing a mixture of hydrochloride salts of opium alkaloids. ...
This article is about the drug. ...
Oripavine is an opiate and the major metabolite of thebaine. ...
Not to be confused with oxytocin. ...
Oxymorphone (Opana, Numorphan) or 14-Hydroxydihydromorphinone is a powerful semi-synthetic opioid analgesic that is derived from thebaine, and is approximately 6â8 times more potent than morphine. ...
Pantopon is a preparation of opiates made up of all of the alkaloids present in opium in their natural proportions as hydrochloride salts . ...
Papaveretum (BAN) is a preparation containing a mixture of hydrochloride salts of opium alkaloids. ...
Paregoric, or camphorated tincture of opium, is a medication known for its antidiarrheal, antitussive, and analgesic properties. ...
Pholcodeine is an opioid used primarily as an antitussant (to treat cough) with little abuse potential. ...
The chemical structure of dihydrocodeinone enol acetate Dihydrocodeinone Enol Acetate, or Thebacon, formerly marketed as its hydrochloride salt under the trade name Acedicon, is a semisynthetic opioid once used as an antitussive, primarily in Europe. ...
A minor constituent of opium, thebaine or paramorphine (C19H21NO3) is chemically similar to both morphine and codeine, but produces stimulatory rather than depressant effects. ...
| | Morphinans | Butorphanol • Cyclorphan • Dextro-3-hydroxy-N-allylmorphinan • Dextrorphan • Drotebanol • Levargorphan • Levallorphan • Levorphanol • Levorphan • Levophenacylmorphan • Levomethorphan • Norlevorphanol • Oxilorphan • Phenomorphan • Racemethorphan • Racemorphan Morphinan is the base chemical structures of a subgroup of opioids. ...
Butorphanol (INN) is a morphinan-type synthetic opioid analgesic marketed in the U.S. under the trade name Stadol. ...
Dextrorphan is a pharmacologically active metabolite of Dextromethorphan (DXM). ...
Levorphanol is an opioid medication used to treat severe pain. ...
Levomethorphan is an optical isomer of dextromethorphan. ...
Oxilorphan is an opioid antagonist from the morphinan family of drugs. ...
Phenomorphan is an opioid analgesic. ...
Racemethorphan is a racemic mixture of the stereoisomers of methorphan , namely dextromethorphan , which is the active ingredient in DM cough syrups , and the lesser known levomethorphan which is described as a controlled substance in The Merck Index - likely because it has more potential for abuse than its dextro enantiomer . ...
| | Benzomorphans | Bremazocine • Cyclazocine • Dezocine • Ethylketocyclazocine • Ketazocine • Metazocine • Pentazocine • Phenazocine Cyclazocine is a mixed opiate agonist-antagonist. ...
Dezocine (Dalgan, WY-16225) is an opioid analgesic related to pentazocine, with a similar profile of effects that include analgesic action and euphoria at low doses,[1] but produces dysphoria and hallucinations at high doses, most likely due to action at κ-opioid receptors. ...
Ketazocine (INN) is a cyclazocine derivative used in opioid receptor research. ...
Metazocine is an opioid analgesic related to pentazocine. ...
Pentazocine is a synthetically-prepared narcotic (opioid analgesic) drug used to treat mild to moderately severe pain. ...
Phenazocine (Prinadol, Narphen) is an opioid analgesic, invented in the 1950s,[1][2] which is related to pentazocine and has a similar profile of effects that include analgesic action and euphoria, but may produce dysphoria and hallucinations at high doses, most likely due to action at κ-opioid and Ï receptors. ...
| | 4-Phenylpiperidines | | Pethidines (Meperidines) | Anileridine • Benzethidine • Carperidine • Difenoxin • Diphenoxylate • Etoxeridine (Carbetidine) • Furethidine • Hydroxypethidine (Bemidone) • Morpheridine • Oxpheneridine (Carbamethidine) • Pethidine (Meperidine) • Pethidine Intermediate A • Pethidine Intermediate B (Norpethidine) • Pethidine Intermediate C (Pethidinic Acid) • Pheneridine • Phenoperidine • Piminodine • Properidine (Ipropethidine) • Sameridine • WIN-7681 Pethidine (INN) or meperidine (USAN) (also referred to as: isonipecaine; lidol; pethanol; piridosal; Algil®; Alodan®; Centralgin®; Demerol®; Dispadol®; Dolantin®; Dolargan® (in Poland);[1] Dolestine®; Dolosal®; Dolsin®; Mefedina®) is a fast-acting opioid analgesic drug. ...
Anileridine (Leritine®) is a synthetic opioid and strong analgesic medication. ...
Benzethidine is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine). ...
Carperidine is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine). ...
Difenoxin (Motofen) is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine). ...
On opiod agonist used for the treatment of diarrhea. ...
Etoxeridine (Carbetidine, Atenos) is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine). ...
Furethidine is a 4-phenylpiperidine derivative that is related to the opioid analgesic drug pethidine (meperidine). ...
Hydroxypethidine (Bemidone) is an opioid analgesic that is an analogue of pethidine (meperidine). ...
Pethidine (INN) or meperidine (USAN) (also referred to as: isonipecaine; lidol; pethanol; piridosal; Algil®; Alodan®; Centralgin®; Demerol®; Dispadol®; Dolantin®; Dolargan® (in Poland);[1] Dolestine®; Dolosal®; Dolsin®; Mefedina®) is a fast-acting opioid analgesic drug. ...
Phenoperidine is an opiod general anesthetic. ...
Piminodine (Alvodine) is an opioid analgesic that is an analogue of pethidine (meperidine). ...
Properidine is an opiate analgesic and the isopropyl analog of Meperidine. ...
| | Prodines | Allylprodine • α-meprodine • α-prodine • β-meprodine • β-prodine • Meprodine • MPPP • PEPAP • Prodine • Prosidol • Trimeperidine Prodine (Prisilidine, Nisentil) is an opioid analgesic that is an analogue of pethidine (meperidine). ...
Allylprodine is an opioid analgesic that is an analogue of prodine. ...
Meprodine is an opioid analgesic that is an analogue of pethidine (meperidine). ...
Prodine (Prisilidine, Nisentil) is an opioid analgesic that is an analogue of pethidine (meperidine). ...
Meprodine is an opioid analgesic that is an analogue of pethidine (meperidine). ...
Prodine (Prisilidine, Nisentil) is an opioid analgesic that is an analogue of pethidine (meperidine). ...
Meprodine is an opioid analgesic that is an analogue of pethidine (meperidine). ...
MPPP (1-methyl 4-phenyl 4-propionoxypiperidine) is an opioid analgesic drug. ...
Prodine (Prisilidine, Nisentil) is an opioid analgesic that is an analogue of pethidine (meperidine). ...
Prosidol is an opioid analgesic that is an analogue of prodine. ...
Trimeperidine (Promedol) is an opioid analgesic that is an analogue of prodine. ...
| | Ketobemidones | Acetoxyketobemidone • Ketobemidone • Methylketobemidone • Propylketobemidone Ketobemidone structure Ketobemidone is a powerful opioid analgesic. ...
Acetoxyketobemidone (O-Acetylketobemidone) is an opioid analgesic that is an acetylated derivative of ketobemidone. ...
Ketobemidone structure Ketobemidone is a powerful opioid analgesic. ...
Methylketobemidone is an opioid analgesic that is an analogue of ketobemidone. ...
Propylketobemidone is an opioid analgesic that is an analogue of ketobemidone. ...
| | Others | Alvimopan • Loperamide • Picenadol | | | Open Chain Opioids | | Amidones | Dextromethadone • Dipipanone • Isomethadone • Levomethadone • Methadone • Methadone Intermediate • Norpipanone • Phenadoxone (Heptazone) • Pipidone Alvimopan (Entereg) is a drug which behaves as a peripherally acting μ-opioid antagonist. ...
Imodium redirects here. ...
Dipipanone hydrochloride is an opioid painkiller. ...
Methadone is a synthetic opioid, used medically as an analgesic and anti-addictive. ...
Phenadoxone (Heptalgin®) is an opioid analgesic of the open chain class (methadone and relatives) invented in Germany in 1947. ...
| | Methadols | Acetylmethadol • α-methadol • α-acetylmethadol • β-methadol • β-acetylmethadol • Dimepheptanol • Levo-α-acetylmethadol • Noracymethadol Levomethadyl acetate, also known as levo-α-acetylmethadol (LAAM) is a synthetic opioid similar in structure to methadone. ...
| | Moramides | Dextromoramide • Levomoramide • Moramide Intermediate • Racemoramide Dextromoramide (Palfium®, Palphium®, Jetrium®, Dimorlin®) is the right-handed isomer of the moramide molecule. ...
| | Thiambutenes | Diethylthiambutene • Dimethylthiambutene • Ethylmethylthiambutene Diethylthiambutene (N,N-Diethyl-1-methyl-3,3-di-2-thienylallylamine, Diethibutin, Themalon) is an opioid analgesic drug which was mainly used in veterinary medicine. ...
Dimethylthiambutene (N,N-Dimethyl-1-methyl-3,3-di-2-thienylallylamine, Dimethibutin, Ohton) is an opioid analgesic drug. ...
Ethylmethylthiambutene (N-ethyl-N-methyl-1-methyl-3,3-di-2-thienylallylamine, Emethibutin) is an opioid analgesic drug. ...
| | Phenalkoxams | Dextropropoxyphene • Dimenoxadol • Dioxaphetyl Butyrate • Levopropoxyphene • Propoxyphene Dextropropoxyphene is an analgesic in the opioid category. ...
Dimenoxadol (Estocin) is an opioid analgesic which is a diphenylacetic acid derivative, related to other drugs such as dextropropoxyphene. ...
Dioxaphetyl Butyrate (Amidalgon, Spasmoxal) is an opioid analgesic which is a diphenylacetic acid derivative, related to other drugs such as dextropropoxyphene. ...
The structure of Levopropoxyphene Levopropoxyphene is an antitussive. ...
Dextropropoxyphene is an analgesic in the opioid category that is used to treat severe pain and severe coughs. ...
| | Ampromides | Diampromide • Phenampromide • Propiram Diampromide is an opioid analgesic from the ampromide family of drugs, related to other drugs such as propiram. ...
Phenampromide is an opioid analgesic from the ampromide family of drugs, related to other drugs such as propiram and diampromide. ...
Propiram (Algeril) is an opioid analgesic from the ampromide family of drugs. ...
| | Others | Lefetamine | | | Anilidopiperidines | 3-allylfentanyl • 3-methylfentanyl • 3-methylthiofentanyl • Alfentanil • α-methylacetylfentanyl • α-methylfentanyl • α-methylthiofentanyl • Benzylfentanyl • β-hydroxyfentanyl • β-hydroxythiofentanyl • β-methylfentanyl • Brifentanil • Carfentanil • Fentanyl • Lofentanil • Ohmefentanyl • Parafluorofentanyl • Phenaridine • Remifentanil • Sufentanil • Thenylfentanyl • Thiofentanyl • Trefentanil Lefetamine is a psychoactive drug which has effects similar to both morphine and methylphenidate. ...
3-Allylfentanyl is an opioid analgesic that is an analogue of fentanyl. ...
3-Methylfentanyl (3-MF, mefentanyl) is an opioid analgesic that is an analogue of fentanyl. ...
3-methyl-thiofentanyl is an opioid analgesic that is an analogue of fentanyl. ...
Alfentanil (Alfenta) is a parenteral short-acting opioid painkiller, used for anaesthesia in surgery. ...
α-methylacetylfentanyl is an opioid analgesic that is an analogue of fentanyl. ...
α-methylfentanyl is an opioid analgesic that is an analogue of fentanyl. ...
α-methyl-thiofentanyl is an opioid analgesic that is an analogue of fentanyl. ...
β-hydroxyfentanyl is an opioid analgesic that is an analogue of fentanyl. ...
β-hydroxythiofentanyl is an opioid analgesic that is an analogue of fentanyl. ...
β-Methylfentanyl is an opioid analgesic that is an analogue of fentanyl. ...
Brifentanil (A-3331) is an opioid analgesic that is an analogue of fentanyl and was developed in the early 1990s. ...
Carfentanil, also Carfentanyl, is an analogue of the popular opioid Fentanyl, and is currently the most potent opioid known [Actually Ohmefentanil is 13,000X morphine]. It has a quantitative potency approximately 10,000 times that of morphine and 100 times that of fentanyl (activity in humans starting at about 1...
Fentanyl is an opioid analgesic, first synthesized by Janssen Pharmaceutica (Belgium) in the late 1950s, with a potency many times that of morphine. ...
Lofentanil is an opioid analgesic that is an analogue of fentanyl and was developed in the early 1980s. ...
This article or section is not written in the formal tone expected of an encyclopedia article. ...
Para-fluorofentanyl is an opioid analgesic that is an analogue of fentanyl. ...
Remifentanil is a potent ultra short-acting synthetic opioid analgesic drug. ...
Sufentanil is a synthetic opioid analgesic drug approximately 5 to 10 times more potent than fentanyl. ...
Thiofentanyl is an opioid analgesic that is an analogue of fentanyl. ...
Trefentanil (A-3665) is an opioid analgesic that is an analogue of fentanyl and was developed in the early 1990s. ...
| | Oripavine derivatives | 7-PET • Acetorphine • Buprenorphine • Cyprenorphine • Dihydroetorphine • Diprenorphine • Etorphine Oripavine is an opiate and the major metabolite of thebaine. ...
7-PET is a potent analgesic drug, several thousand times stronger than morphine by weight. ...
Acetorphine is a potent analgesic drug (painkiller), several thousand times stronger than morphine by weight. ...
Buprenorphine, is an opioid drug with partial agonist and antagonist actions. ...
Cyprenorphine (M-285) is a drug which is an opioid derivative. ...
China is one of the only countries in the world to prescribe Dihydroetorphine, (a close relative of Etorphine) to humans. ...
Diprenorphine (Revivon, M5050) is an opiate antagonist used to reverse the effects of the super-potent opioid analgesics such as etorphine and carfentanil that are used for tranquilizing large animals in veterinary medicine. ...
Etorphine (Immobilon® or M99) is a synthetic cousin of morphine and 1000 - 80,000 times more powerful. ...
| | Phenazepines | Ethoheptazine • Meptazinol • Metheptazine • Metethoheptazine • Proheptazine Ethoheptazine (Zactane, Equagesic) is an opioid analgesic from the phenazepine family. ...
Meptazinol is an opioid analgesic for use with moderate to severe pain, most commonly used to treat pain in obstetrics (childbirth). ...
Metheptazine is an opioid analgesic from the phenazepine family. ...
Metethoheptazine (WY-535) is an opioid analgesic from the phenazepine family. ...
Proheptazine is an opioid analgesic from the phenazepine family. ...
| | Pirinitramides | Bezitramide • Piritramide Bezitramide (4-[4-(2-oxo-3-propanoyl-benzoimidazol-1-yl)-1-piperidyl]-2,2-diphenyl-butanenitrile MW: 492. ...
Piritramide (Dipidolor®) is a synthetic opioid analgesic with about 65-75 percent of the mg-for-mg strength of morphine. ...
| | Benzimidazoles | Clonitazene • Etonitazene Clonitazene is an opioid analgesic. ...
Etonitazene is a highly potent narcotic analgesic (1000-1500x morphine). ...
| | Others | Ciramadol • Faxeladol • Herkinorin • Methopholine • Narcotine • O-Desmethyltramadol • SNC-80 • Tapentadol • Tilidine • Tramadol • Zipeprol Ciramadol (WY-15705) is an opioid analgesic that was developed in the late 1970s. ...
Faxeladol is an opioid analgesic. ...
Herkinorin is an opioid analgesic that is an analogue of the natural product Salvinorin A. It was discovered in 2005 during structure-activity relationship studies into neoclerodane diterpenes, the family of chemical compounds of which Salvinorin A is a member. ...
Methopholine is an opioid analgesic drug invented in the 1960s. ...
Noscapine (also known as Narcotine) is an alkaloid opioid agonist from plants of the Papaveraceae family, without significant painkilling properties [1]. It is grouped as part of the benzylisoquinolines, of which papaverine is also included. ...
O-Desmethyltramadol (M1) is an opioid analgesic which is made in the body from tramadol. ...
Tapentadol (INN) is a centrally-acting analgesic with a unique dual mode of action as an agonist at the μ-opioid receptor and as a norepinephrine reuptake inhibitor. ...
Tilidine (INN, USAN), or tilidate (BAN) (Valoron®, Valtran®, Tilidin) is a synthetic opioid analgesic, used for treatment of moderate to severe pain, both acute and chronic[1]. Considered a low- to medium-potency opioid, it has the oral potency of about 0. ...
Tramadol (INN) (IPA: ) is an atypical opioid which is a centrally acting analgesic, used for treating mild to moderate pain. ...
Zipeprol is a cough suppressant. ...
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