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Encyclopedia > Methyprylon
Image:Methyprylon.png
Methyprylon
Systematic (IUPAC) name
3,3-diethyl-5-methyl-piperidine-2,4-dione
Identifiers
CAS number 125-64-4
ATC code N05CE02
PubChem 4162
DrugBank APRD00734
Chemical data
Formula C10H17NO2
Mol. weight 183.248 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding 60%
Metabolism  ?
Half life 6-16 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A section of the Anatomical Therapeutic Chemical Classification System. ... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Many drugs are bound to Blood plasma proteins. ... Santorio Santorio (1561-1636) in his steelyard balance, from Ars de statica medecina, first published 1614 Metabolism (from μεταβολισμος (metabolismos)) is the biochemical modification of chemical compounds in living organisms anggjgjhnd cell (b). ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the biological process by which an organism chemically separates waste products from its body. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Methyprylon is a sedative of the piperidinedione derivative family. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... A sedative is a drug that depresses the central nervous system (CNS), which causes calmness, relaxation, reduction of anxiety, sleepiness, slowed breathing, slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes. ...


External links

  • Contos D, Dixon K, Guthrie R, Gerber N, Mays D (1991). "Nonlinear elimination of methyprylon (noludar) in an overdosed patient: correlation of clinical effects with plasma concentration.". J Pharm Sci 80 (8): 768-71. PMID 1686463.
  • Gwilt P, Pankaskie M, Thornburg J, Zustiak R, Shoenthal D (1985). "Pharmacokinetics of methyprylon following a single oral dose.". J Pharm Sci 74 (9): 1001-3. PMID 2866242.
  • Lomen P, Linet O (1976). "Hypnotic efficacy of triazolam and methyprylon ininsomniac in-patients.". J Int Med Res 4 (1): 55-8. PMID 16792.


Sedatives (N05) edit

Chloral Hydrate, Ethchlorvynol, Gamma-butyrolactone, Gamma-hydroxybutyrate, Glutethimide, Meprobamate, Methaqualone, Methyprylon, Propofol A sedative is a drug that depresses the central nervous system (CNS), which causes calmness, relaxation, reduction of anxiety, sleepiness, slowed breathing, slurred speech, staggering gait, poor judgment, and slow, uncertain reflexes. ... A section of the Anatomical Therapeutic Chemical Classification System. ... Chloral hydrate is a sedative and hypnotic drug, also known as trichloroacetaldehyde monohydrate, 2,2,2-trichloro-1,1-ethanediol, and the tradenames Aquachloral, Novo-Chlorhydrate, Somnos, Noctec, and Somnote. ... Ethchlorvynol is a sedative and hypnotic drug. ... gamma-Butyrolactone, also known as GBL, butyrolactone, 1,4-lactone, 4-butyrolactone, 4-hydroxybutyric acid lactone, and gamma-hydroxybutyric acid lactone, is a hygroscopic colorless oily liquid with a weak characteristic odor and medium solubility in water (≥ 10 g / 100 ml). ... GHB redirects here. ... Glutethimide is a hypnotic sedative that was introduced in 1954 as a safe alternative to barbiturates to treat insomnia. ... Meprobamate (marketed under the brand names Miltown® by Wallace Laboratories and Equanil® by Wyeth) is a carbamate derivative which is used as an anxiolytic drug. ... Methaqualone tablets and capsules. ... Propofol is an intravenous anesthetic agent used for the induction of general anesthesia in adult patients and pediatric patients older than 3 years of age; maintenance of general anesthesia in adult patients and pediatric patients older than 2 months of age; and intensive care unit (ICU) sedation for intubated, mechanically...

Barbiturates - Benzodiazepines - Imidazopyridine - Antihistamines - Herbal sedatives Barbiturates are drugs that act as central nervous system (CNS) depressants, and by virtue of this they produce a wide spectrum of effects, from mild sedation to anesthesia. ... alprazolam 2mg tablets The benzodiazepines are a class of drugs with sedative, hypnotic, anxiolytic, anticonvulsant, amnestic and muscle relaxant properties. ... The imidazopyridines are a class of drugs related to benzodiazepines. ... An antihistamine is a drug which serves to reduce or eliminate effects mediated by histamine, an endogenous chemical mediator released during allergic reactions, through action at the histamine receptor. ...


  Results from FactBites:
 
Drug Information: Methyprylon (Systemic) (Print Version) (1021 words)
If methyprylon is used regularly (for example, every day) to help produce sleep, it may not be effective for more than 1 week.This medicine was withdrawn from the U.S. market in June 1965 and the Canadian market in September 1990.
Overdose of methyprylon is especially dangerous in children.
Taking an overdose of methyprylon or taking alcohol or other CNS depressants with methyprylon may lead to unconsciousness and possibly death.
  More results at FactBites »


 

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