FACTOID # 51: Russia won the first World Air Games, held in Turkey in 1997. Events included hang-gliding, sky-surfing, and ballooning.
 
 Home   Encyclopedia   Statistics   Countries A-Z   Flags   Maps   Education   Forum   FAQ   About 
 
WHAT'S NEW
RECENT ARTICLES
More Recent Articles »
 

SEARCH ALL

FACTS & STATISTICS    Advanced view

Search encyclopedia, statistics and forums:

 

 

(* = Graphable)

 

 


Encyclopedia > Michael Smith (chemist)

Michael Smith, CC, OBC (April 26, 1932October 4, 2000) was a British-born Canadian biochemist who was the 1993 Nobel Prize winner in Chemistry. Seal of the Order of Canada The Order of Canada is Canadas highest civilian honour, with membership awarded to those who exemplify the Orders Latin motto Desiderantes meliorem patriam, which means (those) desiring a better country (Hebrews 11. ... The Order of British Columbia is British Columbias highest award for outstanding achievement. ... is the 116th day of the year (117th in leap years) in the Gregorian calendar. ... Year 1932 (MCMXXXII) was a leap year starting on Friday (the link will display full 1932 calendar) of the Gregorian calendar. ... October 4 is the 277th day of the year (278th in leap years) in the Gregorian calendar. ... 2000 (MM) was a leap year starting on Saturday of the Gregorian calendar. ... A biochemist is a scientist trained and dedicated to producing results in the discipline of biochemistry. ... Year 1993 (MCMXCIII) was a common year starting on Friday (link will display full 1993 Gregorian calendar). ... Nobel Prize medal. ... Chemistry - the study of atoms, made of nuclei (conglomeration of center particles) and electrons (outer particles), and the structures they form. ...


Smith received the Prize for his fundamental contributions to the establishment of oligonucleotide-based, site-directed mutagenesis and its development for protein studies. Oligonucleotides are short sequences of nucleotides (RNA or DNA), typically with twenty or fewer base pairs. ... This article is about mutation in biology, for other meanings see: mutation (disambiguation). ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ...


Born in Blackpool, England, he received his PhD in 1956 from the University of Manchester. He went on to do post-doctoral work in Gobind Khorana's Laboratory at the University of British Columbia, Vancouver, Canada. He remained at the University of British Columbia from 1956 until his death in 2000. It has been suggested that South Shore, Blackpool be merged into this article or section. ... Motto (French) God and my right Anthem No official anthem - the United Kingdom anthem God Save the Queen is commonly used England() – on the European continent() – in the United Kingdom() Capital (and largest city) London (de facto) Official languages English (de facto) Unified  -  by Athelstan 927 AD  Area  -  Total 130... The University of Manchester is a university located in Manchester, England. ... Har Gobind Khorana (born January 9, 1922) is a molecular biologist. ... The University of British Columbia (UBC) is a Canadian public university with its main campus located at Point Grey in the unincorporated Electoral Area A, immediately west of Vancouver, British Columbia. ... Year 1956 (MCMLVI) was a leap year starting on Sunday (link will display full calendar) of the Gregorian calendar. ... 2000 (MM) was a leap year starting on Saturday of the Gregorian calendar. ...


In 1987 he became the Director of the University of British Columbia Biotechnology Laboratory. Year 1987 (MCMLXXXVII) was a common year starting on Thursday (link displays 1987 Gregorian calendar). ... The University of British Columbia (UBC) is a Canadian public university with its main campus located at Point Grey in the unincorporated Electoral Area A, immediately west of Vancouver, British Columbia. ...

Contents

Honors

In 1994 Michael Smith was made a Companion of the Order of Canada. Year 1994 (MCMXCIV) was a common year starting on Saturday (link will display full 1994 Gregorian calendar). ... Seal of the Order of Canada The Order of Canada is Canadas highest civilian honour, with membership awarded to those who exemplify the Orders Latin motto Desiderantes meliorem patriam, which means (those) desiring a better country (Hebrews 11. ...


In 2001 the Michael Smith Foundation for Health Research was founded and named after him. Year 2001 (MMI) was a common year starting on Monday (link displays the 2001 Gregorian calendar). ...


In 2004 the UBC Biotechnology Laboratories were renamed the Michael Smith Laboratories in his honor. shelby was here 2004 (MMIV) was a leap year starting on Thursday of the Gregorian calendar. ...


Also in 2004 the new biological sciences research centre at The University of Manchester was named the Michael Smith Building. shelby was here 2004 (MMIV) was a leap year starting on Thursday of the Gregorian calendar. ... The University of Manchester is a university located in Manchester, England. ...


Selected publications

  • Ferrer, J.C., Turano, P., Banci, L., Bertini, I., Morris, I.K., Smith, K.M., Smith, M., Mauk, A.G. (1994). Active site coordination chemistry of the cytochrome c peroxidase Asp235Ala variant: Spectroscopic and functional characterization. Biochem. 33: (25) 7819-7829.
  • Guillemette, J.G., Barker, P.D., Eltis, L.D., Lo, T.P., Smith, M., Brayer, G.D., Mauk, A.G. (1994). Analysis of the biomolecular reducation of ferricytochrome c by ferrocytochrome b5 through mutagenesis and molecular modelling. Biochimie 76: 592-604.
  • Berghuis, A.M., Guillemette, J.G., Smith, M., and Brayer, G.D. (1994). Mutation of tyrosine-67 to phenylamaine in cytochrome c significantly alters the local heme environment. J. Mol. Biol. 235: 1326-1341.
  • Rafferty, S.P., Guillemette, J.G., Smith, M., and Mauk, A.G. (1996). Azide binding and active site dynamics of position-82 variants of ferricytochrome c. Inorg. Chem. Acta.242: 171-177.
  • Woods, A.C., Guillemette, J.G., Parraish, J.C., Smith, M., Wallace, C.J.A. (1996). Synergy in Protein Engineering. Mutagenic manipulation of protein structure to simplify semisynthesis. J. Biol. Chem. 271: (50) 32008-32015.
  • Hildebrand, D.P., Ferrer, J.C., Tang, H.-L., Smith, M., and Mauk, A.G. (1996). Trans effects on cysteine ligation in the proximal His93Cys variant of horse heart myoglobin. Biocchemistry 34: 11598-11605.
  • Hildebrand, D.P., Ferrer, J.C., Tang, H.-L., Luo, Y., Hunter, C.L., Brayer, G.D., Smith, M. and Mauk, A.G. (1996). Efficient coupled oxidation of heme by an active site variant of horse heart myoglobin. J. Am. Chem. Soc. 118: (51) 12909-12915.
  • Maurus, R., Overall, C.M., Bogumil, R., Luo, Y., Mauk, A.G., Smith, M., and Brayer, G.D. (1997). Thermal stabilization of horse heart myoglobin through modification of ahydrophobic cluster in the proximal heme pocket. Biochem. Acta. 1341: 1-13.

External links

  • Michael Smith Labs Biography of Michael Smith
  • Nobel Autobiography

See also

  • Eric Damer and Caroline Astell. "No Ordinary Mike: Michael Smith, Nobel Laureate." Vancouver: Ronsdale Press, 2004.

  Results from FactBites:
 
Reference.com/Encyclopedia/Michael Smith (chemist) (461 words)
Michael Smith, CC, OBC (April 26, 1932 – October 4, 2000) was a British-born Canadian biochemist who was the 1993 Nobel Prize winner in Chemistry.
Smith received the Prize for his fundamental contributions to the establishment of oligonucleotide-based, site-directed mutagenesis and its development for protein studies.
In 2004 the UBC Biotechnology Laboratories were renamed the Michael Smith Laboratories in his honor.
Dr. Michael Smith (654 words)
Michael Smith was born into a working-class family in Blackpool, England in 1932.
In 1993, Dr. Michael Smith received the Nobel Prize for his development of the technique of site-directed mutagenesis, a technique which allows the DNA sequence of any gene to be altered in a designated manner.
Michael Smith was a distinguished and creative scientist, a humble man known for his humanity.
  More results at FactBites »


 

COMMENTARY     


Share your thoughts, questions and commentary here
Your name
Your comments
Please enter the 5-letter protection code

Want to know more?
Search encyclopedia, statistics and forums:

 


Lesson Plans | Student Area | Student FAQ | Reviews | Press Releases |  Feeds | Contact
The Wikipedia article included on this page is licensed under the GFDL.
Images may be subject to relevant owners' copyright.
All other elements are (c) copyright NationMaster.com 2003-5. All Rights Reserved.
Usage implies agreement with terms.