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Encyclopedia > Microangiopathic hemolytic anemia

In medicine (hematology) microangiopathic hemolytic anemia (MAHA) is a subgroup of hemolytic anemia (anemia, loss of red blood cells through destruction) caused by factors in the small blood vessels. It is identified by the finding of anaemia and schistocytes ("bite cells") on microscopy of the blood film.


Automated analysers (the machines that perform routine full blood counts in most hospitals) are generally programmed to flag blood films that display red blood cell fragments or schistocytes.


The most important causes are:

In all causes, the mechanism of MAHA is the formation of a fibrin mesh due to increased activity of the system of coagulation. The red blood cells are physically cut by these protein networks, and the fragments are identical to the schistocytes seen on light microscopy.


  Results from FactBites:
 
Hemolytic Anemia (0 words)
Hemolytic anemia is sometimes caused by a vitamin E deficiency.
When these anemias are present without any accompanying disease or disorder, it is possible that the membrane surface of the RBC is expressing a new protein (antigen) not made elsewhere in the body and therefore, not recognized as part of the normal self.
Hemolytic anemia caused by an Rh factor: This incompatability occurs when an Rh negative mother develops antibodies against the Rh positive blood of the fetus towards the end of her pregnancy.
WSAVA 2001 - Diagnosis of Hemolytic Anemias (2418 words)
Hemolytic anemia may develop upon exposure to several parasitic, bacterial and viral agents due to the direct action of the infecting agent or its products on erythrocytes.
In addition to myopathy and cardiac and neurologic dysfunction, acute hemolytic anemia, characterized by a rapid drop in PCV and mild intravascular lysis and Heinz body formation is observed in animals with hypophosphatemia.
A diagnosis of microangiopathic hemolysis, which is often subclinical and only rarely causes overt intravascular hemolytic anemia, is made by identifying the triggering condition and the characterization of schistocytes (shizocytes).
  More results at FactBites »


 

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