Microangiopathy is a disease process affecting small blood vessels. The arterial system The blood vessels are part of the circulatory system and function to transport blood throughout the body. ...
Diabetic nephropathy
In diabetic nephropathy, glycosylated protein deposits appear diffusely on the basement membranes of capillary loops of the glomeruli, causing microangiopathy of tubules and arterioles. Sometimes, PAS-positive nodular deposits (containing mucopolysaccharides, fibrils and collagen) may appear in the mesangial space, at the periphery of the glomerulus, pushing the capillaries. The lesion is focal (glomeruli are not entirely affected), and some of them are spared. This pattern is also called Kimmelstiel-Wilson lesion. Photomicrography of nodular glomerulosclerosis in Kimmelstein-Wilson syndrome. ... Glycosylation is the process or result of addition of saccharides to proteins and lipids. ... ... Glomerulus refers to two unrelated structures in the body, both named for their globular form. ... Periodic acid-Schiff (PAS) is a staining method used in histology and pathology. ... Glycosaminoglycans (GAGs) are long unbranched polysaccharides, made up of repeating disaccharides that may be sulphated (e. ... Tropocollagen triple helix. ... Mesangial cells are specialized cells around blood vessels in the kidneys. ...
Massive microangiopathy may cause the picture of microangiopathic hemolytic anemia (MAHA). In medicine (hematology) microangiopathic hemolytic anemia (MAHA) is a subgroup of hemolytic anemia (anemia, loss of red blood cells through destruction) caused by factors in the small blood vessels. ...
Angiopathy is a disease of the blood vessels (arteries, veins, and capillaries) that occurs when someone has diabetes for a long time. ... In macroangiopathy, fat and blood clots build up in the large blood vessels, stick to the vessel walls, and block the flow of blood. ...
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