FACTOID # 152: Of the eight countries which include the word "democratic" in their conventional long form name, three are dictatorships: North Korea (Democratic People's Republic of Korea), Laos (Lao People's Democratic Republic) and the Democratic republic of the Congo.
 
 Home   Encyclopedia   Statistics   Countries A-Z   Flags   Maps   Education   Forum   FAQ   About 
 
WHAT'S NEW
RECENT ARTICLES
More Recent Articles »
 

SEARCH ALL

FACTS & STATISTICS    Advanced view

Search encyclopedia, statistics and forums:

 

 

(* = Graphable)

 

 


Encyclopedia > Microglia
Microglia cells positive for lectins
Microglia cells positive for lectins

Microglia are a type of glial cell that act as the immune cells of the Central nervous system (CNS). Microglia, the smallest of the glial cells, can act as phagocytes, cleaning up CNS debris. Most serve as representatives of the immune system in the brain and spinal cord. Image File history File links No higher resolution available. ... Image File history File links No higher resolution available. ... This article or section does not cite its references or sources. ... White Blood Cells is also the name of a White Stripes album. ... A diagram showing the CNS: 1. ... A phagocyte is a cell that ingests and destroys foreign matter such as microorganisms or debris via a process known as phagocytosis. ... A scanning electron microscope image of a single neutrophil (yellow), engulfing anthrax bacteria (orange). ... Italic text // ahh addiing sum spiice iin hurr`` For other uses, see Brain (disambiguation). ... The Spinal cord nested in the vertebral column. ...


Microglia are close cousins of other phagocytic cells including macrophages and dendritic cells. A phagocyte is a cell that ingests and destroys foreign matter such as microorganisms or debris via a process known as phagocytosis. ... A macrophage of a mouse stretching its arms to engulf two particles, possibly pathogens Macrophages (Greek: big eaters, makros = long, phagein = eat) are white blood cells, more specifically phagocytes, acting in the nonspecific defense as well as the specific defense system of vertebrate animals. ... Dendritic cells (DC) are immune cells and form part of the mammal immune system. ...


Microglia are thought to be highly mobile cells that play numerous important roles in protecting the nervous system. Drawing of the structure of cork as it appeared under the microscope to Robert Hooke from Micrographia which is the origin of the word cell. Cells in culture, stained for keratin (red) and DNA (green). ... The Human Nervous System A human being coordinates its nervous system, the activity of the muscles, monitors the organs, constructs and also stops input from the senses, and initiates actions. ...

Contents

Origin

Microglia are derived from myeloid progenitor cells (as are macrophages and dendritic cells) which come from the bone marrow. During embryonic development, however, they migrate to the CNS to differentiate into microglia. After phagocytosis of lipid droplets and other debris (usually from tissue necrosis), microglia are termed "gitter cells". Note that some complexity is omitted from the diagram. ... Grays Anatomy illustration of cells in bone marrow. ... Embryogenesis is the process by which the embryo is formed and develops. ...


Clinical significance

Microglia are also thought to play a role in neurodegenerative disorders such as Alzheimer's disease, dementia, multiple sclerosis and Amyotrophic lateral sclerosis. They are responsible for producing an inflammatory reaction to brain trauma [1] and are the main HIV-1 target cells in the central nervous system.[2]. Neurodegenerative disease is a condition which affects the brain function. ... For other uses, see Dementia (disambiguation). ... Amyotrophic lateral sclerosis (ALS, sometimes called Lou Gehrigs Disease, Maladie de Charcot or motor neurone disease) is a progressive, fatal, neurodegenerative disease caused by the degeneration of motor neurons, the nerve cells in the central nervous system that control voluntary muscle movement. ... An abscess on the skin, showing the redness and swelling characteristic of inflammation. ...


History

Babes described activation of microglia in a rabies case in 1897, but did not know what the clusters of microglia he saw were (Streit et al., 2004). Franz Nissl and F. Robertson first described microglial cells, and Pio del Rio-Hortega, a student of Santiago Ramón y Cajal, first called the cells "microglia" around 1920 [1]. Cell staining techniques in the 1980s showed that microglia are related to macrophages. Franz Nissl Franz Nissl (1860-1919) was born in Frankenthal in the Bavarian Palatinate, the son of Theodor Nissl and Maria Haas. ... Santiago Ramón y Cajal Santiago Ramón y Cajal (May 1, 1852 – October 17, 1934) was a famous Spanish histologist, physician, and Nobel laureate. ... Staining is a biochemical technique of adding a class-specific (DNA, proteins, lipids, carbohydrates) dye to a substrate to qualify or quantify the presence of a specific compound. ...


References

  1. ^ There is some debate in the scientific community as to the effects of microglia; while microglia have been proven to exhibit neuroprotective effects (i.e. inducing neuronal banching), they have also been found responsible for much of the secondary neuronal damage through the secretion of reactive oxygen species. On the other side they have a positive effect in Alzheimer's disease by degrading the so-called [amyloid] plaques. Streit WJ, Mrak RE, Griffin WS. (2004). "Microglia and neuroinflammation: a pathological perspective.". J Neuroinflammation. 1 (1): 14. PubMed. 
  2. ^ Marban C, Suzanne S, Dequiedt F, de Walque S, Redel L, Van Lint C, Aunis D, Rohr O. (2007). "Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing.". The EMBO journal 26 (2): 412-423. PubMed. 

External links

  • Microglia home page at microglia.net
  • The Role of Microglia in the Central Nervous System - Clinical Microbiolgy Reviews October 2004, p. 942-964, Vol. 17, No. 4
  • Creeping into your Head - A Brief Introduction to Microglia - A Review from the Science Creative Quarterly
  • Immune Scavengers Target Alzheimer’s Plaques. Retrieved on 2007-05-09. - from Harvard University

  Results from FactBites:
 
Microglia Reviews (8535 words)
Success is dependent on response of the resident myeloid-cell populations [microglia (MG)] to activation signals, commonly cytokines, and the control of infiltrating macrophage activation during inflammation, both of which appear highly programmed in normal and inflamed retina.
In this review article, we discuss the possible neuroprotective and neurotrophic roles of activated microglia and macrophages that may be generated by the expression of high affinity glutamate transporters and glutamine synthetase, 2 major effectors of glial glutamate metabolism, and the implications for HIV-induced neuronal dysfunction, the underlying cause of HIV dementia.
Microglia and perivascular macrophages are believed to act as antigen-presenting cells during the effector phase of EAE.
JSMF - Researching Brain Cancer: 2001 Research Awards (1216 words)
Perhaps the greatest potential advantage that comes with this strategy is that fact that microglia, which are quite numerous within brain tumors, could be used as microscopical weapons to eliminate those small remaining contingents of brain tumor cells that remain after surgical resection and are responsible for tumor recurrences.
Following is a brief summary of microglia in brain tumors and on the mechanisms thought to play a role in controlling interactions between microglial and tumor cells.
Many of the microglia observed appear to be activated, suggesting that they are in a functional cytotoxic state that enables them to kill tumor cells.
  More results at FactBites »


 

COMMENTARY     


Share your thoughts, questions and commentary here
Your name
Your comments
Please enter the 5-letter protection code

Want to know more?
Search encyclopedia, statistics and forums:

 


Lesson Plans | Student Area | Student FAQ | Reviews | Press Releases |  Feeds | Contact
The Wikipedia article included on this page is licensed under the GFDL.
Images may be subject to relevant owners' copyright.
All other elements are (c) copyright NationMaster.com 2003-5. All Rights Reserved.
Usage implies agreement with terms.