The mineralocorticoid receptor (MR, MLR, MCR), also aldosterone receptor, is officially labelled nuclear receptor subfamily 3, group C, member 2, (NR3C2) and is a receptor with high affinity for mineralocorticoids. It belongs to the steroid hormone receptor family where the ligant enters the cytoplasm, interacts with the receptor and results in a signal transduction affecting the nucleus. Hugo is a masculine name. ... The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... The Protein Data Bank (PDB) is a repository for 3-D structural data of proteins and nucleic acids. ... The Enzyme Commission number (EC number) is a numerical classification scheme for enzymes, based on the chemical reactions they catalyze. ... In biology and evolutionary computation, a locus is the position of a gene (or other significant sequence) on a chromosome. ... Chromosome 4 is one of the 23 pairs of chromosomes in humans. ... Look up affinity in Wiktionary, the free dictionary. ... Mineralocorticoids is a class of steroids characterised by their similarity to aldosterone and their influence on salt and water metabolism. ... Steroid hormone receptors are generally intracellular (specifically cytoplasmatic) receptors that perform signal transduction for steroid hormones. ... Cytoplasm is like jelly-like material that fills cells. ... In biology, signal transduction is any process by which a cell converts one kind of signal or stimulus into another. ... Nucleus usually refers to the center of something, but can mean: In science: Atomic nucleus, the collection of protons and neutrons in the center of an atom that carries the bulk of the atoms mass and positive charge Cell nucleus, the membrane-bound subcellular organelle found in eukaryotes, visible...

The gene for the NR3C2 is a 107 kDA protein on chromosome 4q31.1. The receptor is expressed in may tissues, at high concentrations in the kidneys and sweat glands. Its activation leads to transport of ions and water resulting in an increase in extracellular volume, increase in blood pressure, and decrease in potassium. Human kidneys viewed from behind with spine removed The kidneys are bean-shaped excretory organs in vertebrates. ... Sweating (also called perspiration or sometimes transpiration) is the loss of a watery fluid, consisting mainly of sodium chloride and urea in solution, that is secreted by the sweat glands in the skin of mammals. ...

The receptor is activated by mineralocorticoids such as aldosterone and deoxycorticosterone as well as glucocorticoids, like cortisol and cortison. It also responds to some progestins. Spironolactone is a NR3C2 receptor antagonist. Aldosterone is a steroid hormone synthesized from cholesterol by the enzyme aldosterone synthase. ... Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger similar effects. ... Cortisol is a corticosteroid hormone that is involved in the response to stress; it increases blood pressure and blood sugar levels and suppresses the immune system. ... Progestagens (also spelled progestogens or gestagens) are hormones similar in effect to progesterone, the only natural progestagen. ... Spironolactone (marketed as Aldactone or Spiritone) is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat low-renin hypertension, hypokalemia, and Conns syndrome. ...

Activation of the mineralocorticoid receptor results in translocation to the cell nucleus, homodimerization and binding to hormone response elements on DNA. This results in induction or transrepression of genes controlled by the HRE's and production or cessation of production of proteins. Chromosomal translocation of the 4th and 20th chromosome. ... In cell biology, the nucleus (from Latin nucleus or nuculeus, kernel) is found in all eukaryotic cells and contains the nuclear genes which form most of the cells genetic material. ... Sucrose, or common table sugar, is composed of glucose and fructose. ... The general structure of a section of DNA Deoxyribonucleic acid (DNA) is a nucleic acid —usually in the form of a double helix— that contains the genetic instructions specifying the biological development of all cellular forms of life, and most viruses. ... The term induction has more than one meaning in the English language. ... This stylistic schematic diagram shows a gene in relation to the double helix structure of DNA and to a chromosome (right). ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ...

Related receptors

Receptors with a similar structure include: the androgen receptor, estrogen receptors, glucocorticoid receptor, progesterone receptor, thyroid hormone receptors, Peroxisome proliferator-activated receptors, retinoic acid receptor, farnesoid x receptor, pregnane x receptor, liver X receptor, vitamin D receptor, retinoid x receptor and the constitutive androstane receptor. The androgen receptor is an intracellular steroid receptor that specifically binds testosterone and dihydrotestosterone. ... The estrogen receptor is a receptor for estradiol (the main endogenous estrogen); it is located intracellularly, in parallel with other steroid hormone receptors. ... The ‘’’glucocorticoid receptor’’’ (GR) is a ligand-activated intracytoplasmatic transcription factor that interacts with high affinity to cortisol and other glucocorticoids. ... The progesterone receptor is an intracellular steroid receptor that specifically binds progesterone. ... PPAR gamma In cell biology, peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor isoforms that exist across biology. ...