The Mohawk River is a tributary of the McKenzie River, approximately 16 mi (26 km) long, in west central Oregon in the United States. It drains part of the foothills of the Cascade Range on the southeast end of the Willamette Valley northeast of Springfield.

It rises in northern Lane County, approximately 12 m (19 km) northeast of Springfield. It flows generally southwest and enters the McKenzie form the north on the north side of Springfield.

The river gives it name to the Mohawk River band Kalapuyan Native Americans who inhabited the river valley in the 19th century. They were not at related to the Mohawk tribe in the eastern United States.