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Medscape MEDLINE search: Morphinans (1064 words) |
 | A novel series of morphinans were synthesized, and their binding affinity at and functional selectivity for micro, delta, and kappa opioid receptors were evaluated. |
| Non-competitive inhibitory activities of morphinan and morphine derivatives at the alpha 3 beta 4 Neuronal nicotinic acetylcholine receptor determined using nonlinear chromatography and chemometric techniques. |
| PURPOSE: A series of morphine and morphinan derivatives were chromatographed on a column containing immobilized cellular membranes from a cell line expressing the alpha 3 beta 4 neuronal nicotinic acetylcholine receptor (alpha 3 beta 4 nAChR). |
| Morphinan derivatives and pharmaceutical use thereof - Patent 6177438 (4570 words) |
| A morphinan derivative or its pharmaceutically acceptable acid addition salt represented with, for example, ##STR1## and an analgesic, diuretic, antitussive and brain cell protector having its derivative or its salt as the active ingredient are described. |
| The compound of the present invention possesses strong analgesic activity, diuretic action and antitussive action as a highly selective.kappa.-opioid agonist, allowing it to be used as a useful analgesic, diuretic and antitussive. |
| A pharmaceutical composition comprising a pharmaceutically effective amount of the morphinan derivative according to claim 1, or its pharmaceutically acceptable acid addition salt, and a pharmaceutically acceptable carrier. |
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