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Nicotinamide adenine dinucleotide (NAD+)

Nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) are two important coenzymes found in cells. NADH is the reduced form and NAD+ is the oxidized form of NAD.


NAD is used extensively in glycolysis and the citric acid cycle of cellular respiration. It forms NADP with the addition of a phosphate group (much as ADP forms ATP). NADP is produced in the preliminary cycles of photosynthesis, and is used in the later Calvin cycle of photosynthesis. It is used in many other anabolic reactions in various organisms as well.

MH2 + NAD+ → NADH + H+ + M: + energy, where M is a metabolite.

Two hydrogen ions (a hydride ion and an H+ ion) are transferred from the metabolite. Two electrons are transferred to the positively charged nitrogen, and one hydrogen attaches to the carbon atom opposite to the nitrogen.

The human body synthesises NAD from the in the form of nicotinic acid or nicotinamide.
The human body synthesises NAD from the vitamin niacin in the form of nicotinic acid or nicotinamide.

See also

References and external links

  • NAD and NADP (http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/N/NAD.html)
  • Nicotinamide (http://www.greatvistachemicals.com/pharmaceutical_intermediates/nicotinamide.html)

  Results from FactBites:
 
NADH (391 words)
NADH is found in the muscle tissue of fish and poultry and cattle, as well as in food products made with yeast.
NADH deficiency is known to occur only in the presence of vitamin B3 deficiency, which is rare in Western society except in some alcoholics.
NADH appears to be a chemically unstable molecule that decomposes rapidly.
NADH, ENADA, CoQ10, CO-E1, Fibromyalgia, Chronic Fatigue, ENADAlert (0 words)
NADH is directly involved in the body's cellular immune defensive system and the more NADH in your body the better the DNA repair system functions.
NADH, biologically known as Coenzyme 1 (as it is the most important co-enzyme, also known as Co-E1), is the reduced form of nicotinamide adenine dinucleotide (NAD) with high energy hydrogen (H) which provides energy to the cell.
NADH is necessary for thousands of biochemical reactions within the body and is found naturally in every living cell.
  More results at FactBites »


 

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