The best-known activity of the NMRA is the defining of standards, known as Recommended Practices (RP), for model railroad equipment. Many standards defined by the NMRA are widely followed by the industry and modellers, including their HO scale track and wheel standards (RP25) and their Digital Command Control (DCC) standard set. The RP25 standards in particular have been critical in ensuring the reliability and interoperability of US-prototype model railroad equipment, since practically every manufacturer of such equipment follows the RP25 standards. This is in marked contrast to the British market, in which there is no accepted standard among manufacturers. In Europe, the NEM standard is widely followed, but this is further away from prototype accuracy than the RP25 standard.
The NMRA also considers the education of model railroaders and encouraging learning and improving modellers' skills to be part of its mission. The NMRA runs an achievement program to encourage these skills, and runs modelling contests.
Promotion of the model railroading hobby is also part of the NMRA's purpose.
The NMRA is home of the A.C. Kalmbach Memorial Library which houses enough books for any model railroader to go look and they do have videos that you can check out (just recently, the Kalmbach Memorial Library has been designated as the official railroad library in the sate of Tennessee). From the NMRA Kalmbach Library, you can see the Norfolk Southern Georgia Division and the Tennessee Valley Railroad Museum and see what trains will be running by.
NmrA is unlikely to be an active dehydrogenase, however, as the conserved catalytic tyrosine in SDRs is absent in NmrA, and thus the nucleotide binding to NmrA could have a regulatory function.
NmrA from the A.nidulans strain R153 was expressed in Escherichia coli and purified as described previously (Nichols et al., 2001).
The NmrA coordinates were aligned with the protein structures available in the Protein Data Bank using the distance matrix alignment algorithm DALI (Holm and Sander, 1993).