FACTOID # 48: Many Americans live alone - the United States leads the world in one person households.
 
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4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (abbreviated NNK) is a nitrosamine present in tobacco that is a potent procarcinogen. It is activated by CYP2A6. It is a biomarker of exposure to cigarette smoke. This article or section does not cite its references or sources. ... Species Nicotiana acuminata Nicotiana alata Nicotiana attenuata Nicotiana benthamiana Nicotiana clevelandii Nicotiana excelsior Nicotiana forgetiana Nicotiana glauca Nicotiana glutinosa Nicotiana langsdorffii Nicotiana longiflora Nicotiana obtusifolia Nicotiana paniculata Nicotiana plumbagifolia Nicotiana quadrivalvis Nicotiana repanda Nicotiana rustica Nicotianasuaveolens Nicotiana sylvestris Nicotiana tabacum Nicotiana tomentosa Ref: ITIS 30562 as of August 26, 2005... Cytochrome P450 2A6 (abbreviated CYP2A6) is a member of the cytochrome P450 mixed-function oxidase system, which is involved in the metabolism of xenobiotics in the body. ... Biomarker is an occasionally used synonym for biosignature, which is a term used in astrobiology to indicate a measurable phenomenon that indicates the presence of life. ...


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  Results from FactBites:
 
Biochemistry, Biology, and Carcinogenicity of Tobacco-Specific N-Nitrosamines (14631 words)
NNK and polycyclic aromatic hydrocarbons are the most prevalent pulmonary carcinogens in tobacco smoke; their respective roles in lung cancer induction are discussed in section 5 of this review.
P450s 2A6 and 3A4 are implicated in NNK
GAT mutations in codon 12 of Kras (256).
Lung Cancer and PCBs Animal Studies Part One (8350 words)
Taken together, the results of this study demonstrate that NNK is a transplacental tumorigen in the mouse, with activity that is relatively weak compared with the adult and is demonstrable only in fetal target organs of high sensitivity.
Thus NNK is a weak transplacental carcinogen for sensitive fetal target organs in the mouse.
The bioactivation of NNK to a mutagenic metabolite was achieved by incubation of NNK with liver S9 fraction from Aroclor-1254 induced rats or primary hepatocytes from both untreated and Aroclor-1254 pretreated rats.
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