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Encyclopedia > Nabilone
Nabilone chemical structure
Nabilone
Systematic (IUPAC) name
 ?
Identifiers
CAS number 51022-71-0
ATC code A04AD11
PubChem 5284592
DrugBank APRD01127
Chemical data
Formula C24H36O3
Mol. weight 372.541 g/mol
Pharmacokinetic data
Bioavailability 20% after first-pass by the liver
Metabolism  ?
Half life 2 hours, with metabolites around 35 hours.
Excretion  ?
Therapeutic considerations
Pregnancy cat.

? Image File history File links Nabilone. ... IUPAC nomenclature is a systematic way of naming organic chemical compounds. ... CAS registry numbers are unique numerical identifiers for chemical compounds, polymers, biological sequences and alloys. ... The Anatomical Therapeutic Chemical Classification System is used for the classification of drugs. ... A division of the Anatomical Therapeutic Chemical Classification System A Alimentary tract and metabolism A04A Antiemetics and antinauseants A04AA Serotonin (5-HT3) antagonists A04AA01 Ondansetron A04AA02 Granisetron A04AA03 Tropisetron A04AA04 Dolasetron A04AD Other antiemetics A04AD01 Scopolamine A04AD02 Cerium oxalate A04AD04 Chlorobutanol A04AD05 Metopimazine A04AD10 Dronabinol A04AD11 Nabilone A04AD51 Scopolamine, combinations... PubChem is a database of chemical molecules . ... DrugBank is a database available at the University of Alberta that provides information about thousands of products. ... A chemical formula (also called molecular formula) is a concise way of expressing information about the atoms that constitute a particular chemical compound. ... The molecular mass of a substance (less accurately called molecular weight and abbreviated as MW) is the mass of one molecule of that substance, relative to the unified atomic mass unit u (equal to 1/12 the mass of one atom of carbon-12). ... In pharmacology, bioavailability is used to describe the fraction of an administered dose of medication that reaches the systemic circulation, one of the principal pharmacokinetic properties of drugs. ... Overview of the citric acid cycle The citric acid cycle, one of the central metabolic pathways in aerobic organisms. ... The elimination half-life of a drug (or any xenobiotic agent) refers to the timecourse necessary for the quantity of the xenobiotic agent in the body (or plasma concentration) to be reduced to half of its original level through various elimination processes. ... Excretion is the process of eliminating waste products of metabolism and other materials that are of no use. ... The pregnancy category of a pharmaceutical agent is an assessment of the risk of fetal injury due to the pharmaceutical, if it is used as directed by the mother during pregnancy. ...

Legal status
Routes  ?

Nabilone is a cannabinoid with therapeutic use as an antiemetic. It is an analog of dronabinol (also known as tetrahydrocannabinol or THC), the psychoactive ingredient in cannabis[1]. The regulation of therapeutic goods, that is drugs and therapeutic devices, varies by jurisdiction. ... In pharmacology and toxicology, a route of administration is the path by which a drug, fluid, poison or other substance is brought into contact with the body 1. ... Cannabinoids are a group of chemicals which activate the bodys cannabinoid receptors. ... An antiemetic is a drug that is effective against vomiting and nausea. ... Tetrahydrocannabinol, also known as THC, Δ9-THC, Δ9-tetrahydrocannabinol, Δ1-tetrahydrocannabinol (using an older numbering scheme), or dronabinol, is the main psychoactive substance found in the hemp plant Cannabis sativa. ... Tetrahydrocannabinol, also known as THC, Δ9-THC, Δ9-tetrahydrocannabinol (delta-9-tetrahydrocannabinol), Δ¹-tetrahydrocannabinol (using an older numbering scheme), or dronabinol, is the main psychoactive substance found in the Cannabis plant. ... Look up Cannabis in Wiktionary, the free dictionary. ...


In Canada, the United States, and the United Kingdom, nabilone is marketed as Cesamet. It is approved by the FDA for treatment of chemotherapy-induced nausea and vomiting that has not responded to conventional antiemetics. It is also approved for use in treatment of anorexia and weight loss in patients with AIDS.


Nabilone is a racemate consisting of the (S,S) and the (R,R) isomers ("trans"). In chemistry, a racemate is a mixture of equal amounts of left- and right-handed stereoisomers of a chiral molecules. ... In chemistry, isomers are molecules with the same chemical formula and often with the same kinds of bonds between atoms, but in which the atoms are arranged differently. ... Trans is a Latin word meaning across, beyond or on the opposite side and is the opposite of cis, which means on the same side. In chemistry, a bond not subject to free rotation in which the greater radical on both ends is on the opposite side of the bond...


References

  • Compounds That Bind to Cannabinoid Receptors, Table 2.2, Marijuana and Medicine: Assessing the Science Base, Institute of Medicine.


[edit]Cannabinoids

Anandamide • 2-AG • CBD • CBDV • CBN • CBV • CP 55,940 • HU-210 • Levonantradol • JWH-133 • Nabilone • THC • THCV • URB597  • URB754 • WIN 55,212-2 • SR141716A • AM251 Cannabinoids are a group of chemicals which activate the bodys cannabinoid receptors. ... Anandamide, also known as arachidonoylethanolamine or AEA, is a naturally occurring endogenous cannabinoid neurotransmitter found in the brain of animals, as well as other organs. ... ... Cannabidiol, also known as CBD, is a non-psychoactive cannabinoid found in the hemp plant Cannabis sativa. ... Cannabidivarine, also known as cannabidivarol or CBDV, is a non_psychoactive cannabinoid found in minor amounts in the hemp plant Cannabis sativa. ... Cannabinol, also known as CBN, is a non_psychoactive cannabinoid found in the hemp plant Cannabis sativa. ... Cannabivarin, also known as cannabivarol or CBV, is a non_psychoactive cannabinoid found in minor amounts in the hemp plant Cannabis sativa. ... Chemical structure of CP 55,940 CP 55,940, also written as CP55940, CP55,940, CP-55940, CP-55,940, and CP 55940, is a cannabinoid which mimics the effects of naturally occurring THC (the psychoactive compound found in marijuana). ... HU-210 HU-210 (CAS# 112830-95-2) is a synthetic cannabinoid that was discovered around 1988 in the group of Dr Raphael Mechoulam at the Hebrew University. ... Levonantradol is a synthetic cannabinoid analog of dronabinol (Marinol). ... JWH-133 is a potent selective CB2 receptor agonist. ... Tetrahydrocannabinol, also known as THC, Δ9-THC, Δ9-tetrahydrocannabinol (delta-9-tetrahydrocannabinol), Δ¹-tetrahydrocannabinol (using an older numbering scheme), or dronabinol, is the main psychoactive substance found in the Cannabis plant. ... Tetrahydrocannabivarin, also known as tetrahydrocannabivarol, THCV, or THV, is a psychoactive cannabinoid found in minor amounts in the hemp plant Cannabis sativa. ... URB597 urb597 In pre-clinical laboratory tests researchers found URB597 increased the production of endocannabinoids by blocking their degradation, resulting in measurable antidepressant effects. ... urb754 2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the central cannabinoid receptor (CB1) receptor. ... WIN 55,212-2 is a chemical agent in the Cannabnoid family. ... Rimonabant or SR141716A is an anorectic anti-obesity drug. ... AM251 is a CB1 cannabinoid receptor antagonist. ...


  Results from FactBites:
 
NABILONE Faq (492 words)
Nabilone is a narcotic medication used to treat severe nausea and vomiting.
Nabilone comes as 1 mg blue and white pulvules.
Nabilone will add to the effects of alcohol and other central nervous system depressants such as sedatives, muscle relaxants, narcotics, medicines for seizures and antihistamines.
Nabilone - Patient UK (0 words)
Nabilone is used to treat nausea (feeling sick) and vomiting (being sick) caused by cancer chemotherapy or radiotherapy.
Nabilone should be taken at bedtime the night before treatment and again, the following day, one to three hours before treatment as directed.
If nabilone is being taken to stop nausea caused by chemotherapy and radiotherapy, a dose should be taken one to two hours before treatment and followed by another dose twelve hours later.
  More results at FactBites »


 

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