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Encyclopedia > Nerve growth factor
Nerve Growth Factor (NGF) (PDB code: 1bet) (more details...)
nerve growth factor, beta polypeptide
Identifiers
Symbol NGFB
HUGO 7808
Entrez 4803
OMIM 162030
RefSeq NM_002506
UniProt P01138
Other data
Locus Chr. 1 p13.1

Nerve growth factor (NGF), is a small secreted protein which induces the differentiation and survival of particular target neurons (nerve cells). It is perhaps the prototypical growth factor, in that it is one of the first to be described - that work by Rita Levi-Montalcini and Stanley Cohen was rewarded with a Nobel Prize. Image File history File links No higher resolution available. ... Hugo is a masculine name. ... The Entrez logo The Entrez Global Query Cross-Database Search System allows access to databases at the National Center for Biotechnology Information (NCBI) website. ... The Mendelian Inheritance in Man project is a database that catalogues all the known diseases with a genetic component, and - when possible - links them to the relevant genes in the human genome. ... The National Center for Biotechnology Information (NCBI) is part of the US National Library of Medicine (NLM), which is a branch of the US National Institutes of Health. ... Swiss-Prot is a curated biological database of protein sequences created in 1986 by Amos Bairoch during his PhD and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute. ... Short and long arms Chromosome. ... Chromosome 1 is, by convention, the designation for the largest human chromosome. ... A representation of the 3D structure of myoglobin, showing coloured alpha helices. ... Neurons (also called nerve cells) are the primary cells of the nervous system. ... Growth factor is a protein that acts as a signaling molecule between cells (like cytokines and hormones) that attaches to specific receptors on the surface of a target cell and promotes differentiation and maturation of these cells. ... Rita Levi Montalcini. ... Stanley Cohen can refer to: Stanley Cohen - neurologist, Nobel Prize winner Stanley Cohen - former MP for Leeds, South-East Stanley Cohen - sociologist Stanley Cohen - geneticist Stanley Cohen - author STANLEY COHEN and RITA LEVI-MONTALCINI for their discoveries of growth factors. ... The Nobel Prizes (Swedish: ) are awards in physics, chemistry, literature, peace, and physiology or medicine. ...

Contents

Function

NGF is critical for the survival and maintenance of sympathetic and sensory neurons. The mechanism of the reflex arc Sensory neurons (or neurones) are nerve cells within the nervous system responsible for converting external stimuli from the organisms environment into internal [[electrical poop is responsible for it aright underlie motor reflex loops and several forms of involuntary behavior, including pain avoidance. ... Drawing by Santiago Ramón y Cajal of neurons in the pigeon cerebellum. ...


NGF is released from the target cells, binds to and activates its high affinity receptor (TrkA), and is internalized into the responsive neuron. The NGF/TrkA complex is subsequently trafficked back to the cell body. This movement of NGF from axon tip to soma is thought to be involved in the long-distance signaling of neurons. Target cells are the sites where hormones act. ... // TrkA is the high affinity receptor for the neurotrophin, Nerve Growth Factor, or NGF. As such, it mediates the multiple effects of NGF, which includes neuronal differentiation and survival. ... The soma is the bulbous end of a neuron, containing the nucleus. ... An axon or nerve fiber, is a long, slender projection of a nerve cell, or neuron, that conducts electrical impulses away from the neurons cell body or soma. ... The soma is the bulbous end of a neuron, containing the nucleus. ...


Receptor binding mechanism

NGF binds at least two receptors on the surface of cells which are capable of responding to this growth factor, TrkA (pronounced "Track A") and the LNGFR (for "low affinity nerve growth factor receptor"). // TrkA is the high affinity receptor for the neurotrophin, Nerve Growth Factor, or NGF. As such, it mediates the multiple effects of NGF, which includes neuronal differentiation and survival. ... The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor-types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate. ... The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor-types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate. ...


TrkA, B, and C receptors

TrkA is a receptor tyrosine kinase (meaning it mediates its actions by causing the addition of phosphate molecules on certain tyrosines in the cell, activating cellular signaling). // TrkA is the high affinity receptor for the neurotrophin, Nerve Growth Factor, or NGF. As such, it mediates the multiple effects of NGF, which includes neuronal differentiation and survival. ... The receptor tyrosine kinase (RTK) family of cell surface receptors shows a high affinity to numerous growth signals. ... Above is a ball-and-stick model of the inorganic hydrogenphosphate anion (HPO42−). Colour coding: P (orange); O (red); H (white). ...


There are other related Trk receptors (TrkB and TrkC), and there are other neurotrophic factors structurally related to NGF (BDNF, NT-3, and NT-4) // Function TrkB is the high affinity receptor for several neurotrophins, which are small protein growth factors that induce the survival and differentiation of distinct cell populations. ... // TrkC is the high affinity receptor for the neurotrophin NT-3 (neurotrophin-3). ... Brain-derived neurotrophic factor (BDNF) is exactly as it states; a neurotrophic factor usually derived in the brain. ... Neurotrophin-3, or NT-3 is a neurotrophic factor, in the NGF (Nerve Growth Factor)-family of neurotrophins. ... NT-4 like (BDNF) is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase. ...

  • TrkA mediates the effects of NGF
  • TrkB binds and is activated by BDNF, NT-4, and NT-3
  • TrkC binds and is activated only by NT-3

// TrkA is the high affinity receptor for the neurotrophin, Nerve Growth Factor, or NGF. As such, it mediates the multiple effects of NGF, which includes neuronal differentiation and survival. ... // Function TrkB is the high affinity receptor for several neurotrophins, which are small protein growth factors that induce the survival and differentiation of distinct cell populations. ... Brain-derived neurotrophic factor (BDNF) is exactly as it states; a neurotrophic factor usually derived in the brain. ... NT-4 like (BDNF) is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase. ... Neurotrophin-3, or NT-3 is a neurotrophic factor, in the NGF (Nerve Growth Factor)-family of neurotrophins. ... // TrkC is the high affinity receptor for the neurotrophin NT-3 (neurotrophin-3). ... Neurotrophin-3, or NT-3 is a neurotrophic factor, in the NGF (Nerve Growth Factor)-family of neurotrophins. ...

LNGFR receptor

The other NGF receptor, the LNGFR, (for Low affinity nerve growth factor receptor, commonly known as "p75", plays a less clear role. The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor-types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate. ... The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor-types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate. ...


LNGFR binds and serves as a "sink" for neurotrophins. Cells which express both the LNGFR and the Trk receptors might therefore have a greater activity - since they have a higher "microconcentration" of the neurotrophin.


However, although NGF has been classically described as promoting neuron survival and differentiation, research performed in the early 2000's suggest that NGF with its prodomain attached (proNGF) can elicit apoptosis of cells that are positive for the LNGFR and negative for TrkA.[1] The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor-types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate. ... // TrkA is the high affinity receptor for the neurotrophin, Nerve Growth Factor, or NGF. As such, it mediates the multiple effects of NGF, which includes neuronal differentiation and survival. ...


Secreted proNGF has been demonstrated in a variety of neuronal and non-neuronal cell populations. It has been proposed that secreted proNGF can elicit neuron death in a variety of neurodegenerative conditions, including Alzheimers disease, following the observation of an increase of proNGF in the nucleus basalis of postmortem Alzheimer's brains. Drawing by Santiago Ramón y Cajal of neurons in the pigeon cerebellum. ... In neuroanatomy, a nucleus is a central nervous system structure that is composed mainly of gray matter, and which acts as a hub or transit point for electrical signals in a single neural subsystem. ...


History

Stanley Cohen and Rita Levi-Montalcini won the 1986 Nobel Prize in Physiology or Medicine for their discovery of NGF and other growth factors.[2][3][4] Stanley Cohen (born November 17, 1922) is an American researcher and Nobel Prize Laureate in Physiology and Medicine (1986). ... Rita Levi Montalcini. ... List of Nobel Prize laureates in Physiology or Medicine from 1901 to the present day. ...


Cultural significance

NGF has been tied to romantic love.[5][6][7] Love is any of a number of emotions and experiences related to a sense of strong affection or profound oneness. ...


It has also been tied to Alzheimer's disease.[8][9][10]


See also

Protein targeting a. ... The Human Nervous System The nervous system of an animal coordinates the activity of the muscles, monitors the organs, constructs and also stops input from the senses, and initiates actions. ...

References

  1. ^ Ibáñez C (2002). "Jekyll-Hyde neurotrophins: the story of proNGF". Trends Neurosci 25 (6): 284-6. PMID 12086739. 
  2. ^ The 1986 Nobel Prize in Physiology or Medicine for discoveries of growth factors
  3. ^ Presentation Speech by Professor Kerstin Hall The Nobel Prize in Physiology or Medicine 1986
  4. ^ Rita Levi-Montalcini – Nobel Lecture
  5. ^ Emanuele E, Politi P, Bianchi M, Minoretti P, Bertona M, Geroldi D (2006). "Raised plasma nerve growth factor levels associated with early-stage romantic love". Psychoneuroendocrinology 31 (3): 288-94. PMID 16289361.  link
  6. ^ "NGF" gives passionate lovers just one year, Reuters, November 29, 2005.
  7. ^ John Harris Is love just a chemical?, Guardian, November 29, 2005.
  8. ^ Counts S, Mufson E (2005). "The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease". J Neuropathol Exp Neurol 64 (4): 263-72. PMID 15835262. 
  9. ^ Hempstead B (2006). "Dissecting the diverse actions of pro- and mature neurotrophins". Curr Alzheimer Res 3 (1): 19-24. PMID 16472198. 
  10. ^ Allen S, Dawbarn D (2006). "Clinical relevance of the neurotrophins and their receptors". Clin Sci (Lond) 110 (2): 175-91. PMID 16411894. 

External links


  Results from FactBites:
 
Articles on Ashitaba (2173 words)
Nerve growth factor (NGF) is the prototype for the neurotrophin family of polypeptides which are essential in the developments and survival of certain sympathetic and sensory neurons in both the central and peripheral nervous systems.
The NGF is synthesized in minute amounts in all vertebrate tissues, plays an essential role in the differentiation and survival of several nerve cell populations in the peripheral and central nervous system.
NGF is a biological substance which is essential in the development and survival of certain neurons in both the central and peripheral nervous systems.
  More results at FactBites »


 

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