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Nerve growth factor (NGF), is a small secreted protein which induces the differentiation and survival of particular target neurons (nerve cells). It is perhaps the prototypical growth factor, in that it is one of the first to be described - that work by Rita Levi-Montalcini and Stanley Cohen was rewarded with a Nobel Prize. Image File history File links No higher resolution available. ...
Hugo is a masculine name. ...
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Short and long arms Chromosome. ...
Chromosome 1 is, by convention, the designation for the largest human chromosome. ...
A representation of the 3D structure of myoglobin, showing coloured alpha helices. ...
Neurons (also called nerve cells) are the primary cells of the nervous system. ...
Growth factor is a protein that acts as a signaling molecule between cells (like cytokines and hormones) that attaches to specific receptors on the surface of a target cell and promotes differentiation and maturation of these cells. ...
Rita Levi Montalcini. ...
Stanley Cohen can refer to: Stanley Cohen - neurologist, Nobel Prize winner Stanley Cohen - former MP for Leeds, South-East Stanley Cohen - sociologist Stanley Cohen - geneticist Stanley Cohen - author STANLEY COHEN and RITA LEVI-MONTALCINI for their discoveries of growth factors. ...
The Nobel Prizes (Swedish: ) are awards in physics, chemistry, literature, peace, and physiology or medicine. ...
Function
NGF is critical for the survival and maintenance of sympathetic and sensory neurons. The mechanism of the reflex arc Sensory neurons (or neurones) are nerve cells within the nervous system responsible for converting external stimuli from the organisms environment into internal [[electrical poop is responsible for it aright underlie motor reflex loops and several forms of involuntary behavior, including pain avoidance. ...
Drawing by Santiago Ramón y Cajal of neurons in the pigeon cerebellum. ...
NGF is released from the target cells, binds to and activates its high affinity receptor (TrkA), and is internalized into the responsive neuron. The NGF/TrkA complex is subsequently trafficked back to the cell body. This movement of NGF from axon tip to soma is thought to be involved in the long-distance signaling of neurons. Target cells are the sites where hormones act. ...
// TrkA is the high affinity receptor for the neurotrophin, Nerve Growth Factor, or NGF. As such, it mediates the multiple effects of NGF, which includes neuronal differentiation and survival. ...
The soma is the bulbous end of a neuron, containing the nucleus. ...
An axon or nerve fiber, is a long, slender projection of a nerve cell, or neuron, that conducts electrical impulses away from the neurons cell body or soma. ...
The soma is the bulbous end of a neuron, containing the nucleus. ...
Receptor binding mechanism NGF binds at least two receptors on the surface of cells which are capable of responding to this growth factor, TrkA (pronounced "Track A") and the LNGFR (for "low affinity nerve growth factor receptor"). // TrkA is the high affinity receptor for the neurotrophin, Nerve Growth Factor, or NGF. As such, it mediates the multiple effects of NGF, which includes neuronal differentiation and survival. ...
The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor-types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate. ...
The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor-types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate. ...
TrkA, B, and C receptors TrkA is a receptor tyrosine kinase (meaning it mediates its actions by causing the addition of phosphate molecules on certain tyrosines in the cell, activating cellular signaling). // TrkA is the high affinity receptor for the neurotrophin, Nerve Growth Factor, or NGF. As such, it mediates the multiple effects of NGF, which includes neuronal differentiation and survival. ...
The receptor tyrosine kinase (RTK) family of cell surface receptors shows a high affinity to numerous growth signals. ...
Above is a ball-and-stick model of the inorganic hydrogenphosphate anion (HPO42â). Colour coding: P (orange); O (red); H (white). ...
There are other related Trk receptors (TrkB and TrkC), and there are other neurotrophic factors structurally related to NGF (BDNF, NT-3, and NT-4) // Function TrkB is the high affinity receptor for several neurotrophins, which are small protein growth factors that induce the survival and differentiation of distinct cell populations. ...
// TrkC is the high affinity receptor for the neurotrophin NT-3 (neurotrophin-3). ...
Brain-derived neurotrophic factor (BDNF) is exactly as it states; a neurotrophic factor usually derived in the brain. ...
Neurotrophin-3, or NT-3 is a neurotrophic factor, in the NGF (Nerve Growth Factor)-family of neurotrophins. ...
NT-4 like (BDNF) is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase. ...
- TrkA mediates the effects of NGF
- TrkB binds and is activated by BDNF, NT-4, and NT-3
- TrkC binds and is activated only by NT-3
// TrkA is the high affinity receptor for the neurotrophin, Nerve Growth Factor, or NGF. As such, it mediates the multiple effects of NGF, which includes neuronal differentiation and survival. ...
// Function TrkB is the high affinity receptor for several neurotrophins, which are small protein growth factors that induce the survival and differentiation of distinct cell populations. ...
Brain-derived neurotrophic factor (BDNF) is exactly as it states; a neurotrophic factor usually derived in the brain. ...
NT-4 like (BDNF) is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase. ...
Neurotrophin-3, or NT-3 is a neurotrophic factor, in the NGF (Nerve Growth Factor)-family of neurotrophins. ...
// TrkC is the high affinity receptor for the neurotrophin NT-3 (neurotrophin-3). ...
Neurotrophin-3, or NT-3 is a neurotrophic factor, in the NGF (Nerve Growth Factor)-family of neurotrophins. ...
LNGFR receptor The other NGF receptor, the LNGFR, (for Low affinity nerve growth factor receptor, commonly known as "p75", plays a less clear role. The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor-types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate. ...
The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor-types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate. ...
LNGFR binds and serves as a "sink" for neurotrophins. Cells which express both the LNGFR and the Trk receptors might therefore have a greater activity - since they have a higher "microconcentration" of the neurotrophin. However, although NGF has been classically described as promoting neuron survival and differentiation, research performed in the early 2000's suggest that NGF with its prodomain attached (proNGF) can elicit apoptosis of cells that are positive for the LNGFR and negative for TrkA.[1] The Low Affinity Nerve Growth Factor Receptor (also called the LNGFR or p75 neurotrophin receptor) is one of the two receptor-types for the neurotrophins, a family of protein growth factors which stimulate neuronal cells to survive and differentiate. ...
// TrkA is the high affinity receptor for the neurotrophin, Nerve Growth Factor, or NGF. As such, it mediates the multiple effects of NGF, which includes neuronal differentiation and survival. ...
Secreted proNGF has been demonstrated in a variety of neuronal and non-neuronal cell populations. It has been proposed that secreted proNGF can elicit neuron death in a variety of neurodegenerative conditions, including Alzheimers disease, following the observation of an increase of proNGF in the nucleus basalis of postmortem Alzheimer's brains. Drawing by Santiago Ramón y Cajal of neurons in the pigeon cerebellum. ...
In neuroanatomy, a nucleus is a central nervous system structure that is composed mainly of gray matter, and which acts as a hub or transit point for electrical signals in a single neural subsystem. ...
History Stanley Cohen and Rita Levi-Montalcini won the 1986 Nobel Prize in Physiology or Medicine for their discovery of NGF and other growth factors.[2][3][4] Stanley Cohen (born November 17, 1922) is an American researcher and Nobel Prize Laureate in Physiology and Medicine (1986). ...
Rita Levi Montalcini. ...
List of Nobel Prize laureates in Physiology or Medicine from 1901 to the present day. ...
Cultural significance NGF has been tied to romantic love.[5][6][7] Love is any of a number of emotions and experiences related to a sense of strong affection or profound oneness. ...
It has also been tied to Alzheimer's disease.[8][9][10]
See also Protein targeting a. ...
The Human Nervous System The nervous system of an animal coordinates the activity of the muscles, monitors the organs, constructs and also stops input from the senses, and initiates actions. ...
References - ^ Ibáñez C (2002). "Jekyll-Hyde neurotrophins: the story of proNGF". Trends Neurosci 25 (6): 284-6. PMID 12086739.
- ^ The 1986 Nobel Prize in Physiology or Medicine for discoveries of growth factors
- ^ Presentation Speech by Professor Kerstin Hall The Nobel Prize in Physiology or Medicine 1986
- ^ Rita Levi-Montalcini – Nobel Lecture
- ^ Emanuele E, Politi P, Bianchi M, Minoretti P, Bertona M, Geroldi D (2006). "Raised plasma nerve growth factor levels associated with early-stage romantic love". Psychoneuroendocrinology 31 (3): 288-94. PMID 16289361. link
- ^ "NGF" gives passionate lovers just one year, Reuters, November 29, 2005.
- ^ John Harris Is love just a chemical?, Guardian, November 29, 2005.
- ^ Counts S, Mufson E (2005). "The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer disease". J Neuropathol Exp Neurol 64 (4): 263-72. PMID 15835262.
- ^ Hempstead B (2006). "Dissecting the diverse actions of pro- and mature neurotrophins". Curr Alzheimer Res 3 (1): 19-24. PMID 16472198.
- ^ Allen S, Dawbarn D (2006). "Clinical relevance of the neurotrophins and their receptors". Clin Sci (Lond) 110 (2): 175-91. PMID 16411894.
External links Peptide hormones, Steroid hormones Medical Subject Headings (MeSH) is a huge controlled vocabulary (or metadata system) for the purpose of indexing journal articles and books in the life sciences. ...
Major endocrine glands. ...
Norepinephrine A hormone (from Greek ÏÏμή - to set in motion) is a chemical messenger from one cell (or group of cells) to another. ...
An endocrine gland is one of a set of internal organs involved in the secretion of hormones into the blood. ...
Peptide hormones are a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. ...
Steroid hormones are steroids which act as hormones. ...
Hypothalamus: TRH, CRH , GnRH, GHRH, somatostatin, dopamine - Posterior pituitary: vasopressin, oxytocin, lipotropin - Anterior pituitary: α (FSH, LH, TSH), GH, prolactin, POMC (ACTH, MSH, endorphins, lipotropin) - Pineal gland: melatonin The hypothalamus (from Greek á½ÏÎ¿Î¸Î±Î»Î±Î¼Î¿Ï = under the thalamus) is a region of the mammalian brain located below the thalamus, forming the major portion of the ventral region of the diencephalon and functioning to regulate certain metabolic processes and other autonomic activities. ...
Thyrotropin-releasing hormone (TRH), also called thyrotropin-releasing factor (TRF) or protirelin, is a tripeptide hormone that stimulates the release of thyroid-stimulating hormone and prolactin by the anterior pituitary. ...
Corticotropin-releasing hormone (CRH), also called corticotropin-releasing factor (CRF) or corticoliberin, is a polypeptide hormone involved in the stress response. ...
Gonadotropin-releasing hormone 1 (GNRH1 also called LHRH) is a peptide hormone responsible for the release of FSH and LH from the anterior pituitary. ...
Growth hormone-releasing hormone (GHRH), also known as growth hormone-releasing factor (GRF or GHRF), is a 44-amino acid peptide hormone produced in the arcuate nucleus of the hypothalamus. ...
Somatostatin is a hormone. ...
Dopamine is a chemical naturally produced in the body. ...
The posterior pituitary (also called the neurohypophysis) comprises the posterior lobe of the pituitary gland and is part of the endocrine system. ...
Arginine vasopressin (AVP), also known as argipressin or antidiuretic hormone (ADH), is a human hormone that is mainly released when the body is low on water; it causes the kidneys to conserve water by concentrating the urine and reducing urine volume. ...
Oxytocin should not be confused with oxycodone hydrochloride whose trade name is OxyContin. ...
Lipotropin is a pituitary hormone It comes in two forms: gamma lipotropin (γ-LPH) beta lipotropin (β-LPH) It is derived from proopiomelanocortin. ...
The anterior pituitary (also called the adenohypophysis) comprises the anterior lobe of the pituitary gland and is part of the endocrine system. ...
The Alpha subunit of glycoprotein hormones is a peptide formed by gene found on chromosome 6. ...
Follicle stimulating hormone Follicle stimulating hormone (FSH) is a hormone synthesised and secreted by gonadotropes in the anterior pituitary gland. ...
Luteinizing hormone (LH) is a hormone synthesized and secreted by gonadotropes in the anterior lobe of the pituitary gland. ...
Thyroid-stimulating hormone (also known as TSH or thyrotropin) is a hormone synthesized and secreted by thyrotrope cells in the anterior pituitary gland which regulates the endocrine function of the thyroid gland. ...
Growth hormone (GH or somatotropin) is a 191-amino acid, single chain polypeptide hormone which is synthesised, stored and secreted by the somatotroph cells within the lateral wings of the anterior pituitary gland, which stimulates growth and cell reproduction in humans and other animals. ...
Prolactin is a peptide hormone synthesised and secreted by lactotrope cells in the adenohypophysis (anterior pituitary gland). ...
Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. ...
Adrenocorticotropic hormone (ACTH or corticotropin) is a polypeptide hormone synthesised (from POMC, pre-opiomelanocortin) and secreted from corticotropes in the anterior lobe of the pituitary gland in response to the hormone corticotropin-releasing hormone (CRH) released by the hypothalamus. ...
Melanocyte-stimulating hormone (MSH) is a peptide hormone produced by cells in the intermediate lobe of the pituitary gland. ...
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Lipotropin is a pituitary hormone It comes in two forms: gamma lipotropin (γ-LPH) beta lipotropin (β-LPH) It is derived from proopiomelanocortin. ...
The pineal gland (also called the pineal body or epiphysis) is a small endocrine gland in the brain. ...
Melatonin, 5-methoxy-N-acetyltryptamine, is a hormone found in all living creatures from algae[1] to humans, at levels that vary in a diurnal cycle. ...
Thyroid: thyroid hormone (T3 and T4) - calcitonin - Parathyroid: PTH - Adrenal medulla: epinephrine, norepinephrine - Adrenal cortex: aldosterone, cortisol, DHEA - Pancreas: glucagon- insulin, somatostatin The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are tyrosine-based hormones produced by the thyroid gland. ...
The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are tyrosine-based hormones produced by the thyroid gland. ...
The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are tyrosine-based hormones produced by the thyroid gland. ...
Calcitonin is a 32 amino acid polypeptide hormone that is produced in humans primarily by the C cells of the thyroid, and in many other animals in the ultimobranchial body. ...
Categories: Anatomy stubs | Endocrine system ...
Parathyroid hormone (PTH) is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. ...
In mammals, the adrenal gland (also known as suprarenal glands) are the triangle-shaped endocrine glands that sit atop the kidneys; their name indicates that position (ad, near or at + renes, kidneys). They are chiefly responsible for regulating the stress response through the synthesis of corticosteroids and catecholamines, including cortisol...
Adrenaline redirects here. ...
Norepinephrine (INN) or noradrenaline (BAN) is a catecholamine and a phenethylamine with chemical formula C8H11NO3. ...
In mammals, the adrenal gland (also known as suprarenal glands) are the triangle-shaped endocrine glands that sit atop the kidneys; their name indicates that position (ad, near or at + renes, kidneys). They are chiefly responsible for regulating the stress response through the synthesis of corticosteroids and catecholamines, including cortisol...
Aldosterone is a steroid hormone synthesized from cholesterol by the enzyme aldosterone synthase. ...
Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. ...
Dehydroepiandrosterone (DHEA), is a natural steroid hormone produced from cholesterol by the adrenal glands, the gonads, adipose tissue and the brain. ...
The pancreas is an organ in the digestive and endocrine system that serves two major functions: exocrine (producing pancreatic juice containing digestive enzymes) and endocrine (producing several important hormones, including insulin). ...
Glucagon ball and stick model A microscopic image stained for glucagon. ...
Insulin (from Latin insula, island, as it is produced in the Islets of Langerhans in the pancreas) is a polypeptide hormone that regulates carbohydrate metabolism. ...
Somatostatin is a hormone. ...
Kidney: renin, EPO, calcitriol, prostaglandin - Heart atrium: ANP - Stomach: gastrin, ghrelin - Duodenum: CCK, GIP, secretin, motilin, VIP - Ileum: enteroglucagon - Liver: IGF-1 - Adipose tissue: leptin, adiponectin It has been suggested that Renal anomalies and Renal plasma threshold be merged into this article or section. ...
Renin, also known as angiotensinogenase, is a circulating enzyme (EC 3. ...
Erythropoietin (IPA pronunciation: , alternative pronunciations: ) or EPO is a glycoprotein hormone that is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow. ...
Vitamin D is a fat soluble vitamin that contributes to the maintenance of normal levels of calcium and phosphorus in the bloodstream. ...
Chemical structure of prostaglandin E1 (PGE1). ...
In anatomy, the atrium (plural: atria) is the blood collection chamber of a heart. ...
Atrial natriuretic factor (ANF), atrial natriuretic peptide (ANP) or atriopeptin, is a polypeptide hormone involved in the homeostatic control of body water and sodium. ...
With the exception of the animal varients box, this article deals with the human stomach. ...
In humans, gastrin is a hormone that stimulates secretion of gastric acid by the stomach. ...
Ghrelin is a hormone that is produced by cells lining the stomach and stimulates the appetite. ...
In anatomy of the digestive system, the duodenum is a hollow jointed tube connecting the stomach to the jejunum. ...
Cholecystokinin (from Greek chole, bile; cysto, sac; kinin, move; hence, move the bile-sac (gall bladder)) is a peptide hormone of the gastrointestinal system responsible for stimulating the digestion of fat and protein. ...
Gastric inhibitory polypeptide (GIP) is a member of the secretin family of hormones. ...
Secretin is a peptide hormone produced in the S cells of the duodenum. ...
Motilin is a polypeptide hormone secreted by the small intestine that increases gastrointestinal motility and stimulates the production of pepsin. ...
VIP is a peptide hormone containing 28 amino acid residues. ...
Grays Fig. ...
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The liver is an organ in some animals, including vertebrates (and therefore humans). ...
Insulin-like growth factor 1 (IGF-1) is a polypeptide protein hormone similar in molecular structure to insulin. ...
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Leptin (from the Greek word leptos, meaning thin) is a 16 kDa protein hormone that plays a key role in regulating energy intake and energy expenditure, including the regulation of appetite and metabolism. ...
Adiponectin (also referred to as Acrp30, apM1) is a protein hormone that modulates a number of metabolic processes, including glucose regulation and fatty acid catabolism. ...
Testis: testosterone, AMH, inhibin - Ovary: estradiol, progesterone, inhibin/activin, relaxin (pregnancy) - Placenta: hCG, HPL, estrogen, progesterone Human male anatomy The testicles, known medically as testes (singular testis), are the male generative glands in animals. ...
Testosterone is a steroid hormone from the androgen group. ...
Anti-Müllerian hormone (AMH) is a dimeric glycoprotein that inhibits the development of the Müllerian ducts in a male embryo. ...
Inhibin is a peptide that is an inhibitor of FSH synthesis and secretion and participates in the regulation of the menstrual cycle. ...
For ovary as part of plants see ovary (plants) Ovaries are egg-producing reproductive organs found in female organisms. ...
Estradiol (17β-estradiol) (also oestradiol) is a sex hormone. ...
Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. ...
Inhibin is a peptide that is an inhibitor of FSH synthesis and secretion and participates in the regulation of the menstrual cycle. ...
Activin is a peptide that enhances FSH synthesis and secretion and participates in the regulation of the menstrual cycle. ...
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The placenta is an ephemeral (temporary) organ present only in female placental vertebrates during gestation (pregnancy). ...
Human chorionic gonadotropin (hCG) is a peptide hormone produced in pregnancy, that is made by the embryo soon after conception and later by the syncytiotrophoblast (part of the placenta). ...
Human placental lactogen (HPL), also called human chorionic somatomammotropin, is a polypeptide placental hormone. ...
Estriol. ...
Progesterone is a C-21 steroid hormone involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. ...
Target-derived NGF, BDNF, NT-3 Brain-derived neurotrophic factor (BDNF) is exactly as it states; a neurotrophic factor usually derived in the brain. ...
Neurotrophin-3, or NT-3 is a neurotrophic factor, in the NGF (Nerve Growth Factor)-family of neurotrophins. ...
Brain-derived neurotrophic factor - Ciliary neurotrophic factor - GDNF (Glial cell line-derived neurotrophic factor, Neurturin) - Glia maturation factor - Nerve growth factor - Neuregulin - NT-3 - NT-4 - Pituitary adenylate cyclase activating peptide Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. ...
Nervous tissue is the fourth major class of vertebrate tissue. ...
Neurotrophins are a family of molecules that encourage survival of nervous tissue. ...
Brain-derived neurotrophic factor (BDNF) is exactly as it states; a neurotrophic factor usually derived in the brain. ...
Ciliary neurotrophic factor is a nerve growth factor. ...
Glial cell line-Derived Neurotrophic Factor (GDNF) is a small protein that potently promotes the survival of many types of neurons. ...
Neurturin is a ligand used to bind to GFRA2 receptors. ...
Glia maturation factor is a nerve growth factor. ...
A protein of diverse functions in the development of the nervous system. ...
Neurotrophin-3, or NT-3 is a neurotrophic factor, in the NGF (Nerve Growth Factor)-family of neurotrophins. ...
NT-4 like (BDNF) is a neurotrophic factor that signals predominantly through the TrkB receptor tyrosine kinase. ...
Pituitary adenylate cyclase activating peptide is a peptide similar to vasoactive intestinal peptide. ...
Signaling proteins: Hedgehog - Integrin - JAK/STAT (JAK/STAT) - MAPK/ERK pathway (MAPK/ERK) - NF-kB - Notch - p53 - Wnt (Frzb) Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. ...
The hedgehog signaling pathway is one of the key regulators of animal development conserved from flies to humans. ...
An integrin, or integrin receptor, is an integral membrane protein in the plasma membrane of cells. ...
The JAK-STAT signaling pathway takes part in the regulation of cellular responses to cytokines and growth factors. ...
Janus kinase (JAK) is a family of intracellular tyrosine kinases, ranging from 120-140 kDa, that are involved in the JAK-STAT pathway. ...
The Signal Transducers and Activator of Transcription (STAT) protein regulates many aspects of cell growth, survival and differentiation. ...
Diagram showing key components of the MAPK/ERK pathway. ...
In cell biology, mitogen-activated protein kinases (MAPKs) are serine/threonine-specific protein kinases that respond to extracellular stimuli and regulate various cellular activities, such as gene expression, mitosis, differentiation, and cell survival/apoptosis. ...
Extracellular signal-regulated kinases (ERKs) are widely expressed and are involved in the regulation of meiosis, mitosis, and postmitotic functions in differentiated cells. ...
NF-κB, or Nuclear Factor kappa B, is a nuclear transcription factor found in all cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, and bacterial or viral antigens. ...
The Notch pathway is a gene regulatory pathway involved in multiple differentiation processes. ...
TP53 bound to a short DNA fragment. ...
The wnt signalling pathway is a network of proteins that has been implicated in embryogenesis and cancer. ...
Frzb (pronounced like the toy frisbee) is a Wnt-binding protein especially important in embryonic development. ...
Epidermal growth factor - Fibroblast growth factor (FGF2) - Nerve growth factor - Platelet-derived growth factor - Transforming growth factor (TGFα, TGFβ, TGFβ pathway) Epidermal Growth Factor or EGF is a 6045 Da protein with 53 amino acid residues and three intramolecular disulfide bonds. ...
Fibroblast growth factor, or FGF, is a family growth factors involved in wound healing. ...
Member of the Fibroblast Growth Factor family. ...
This article or section is in need of attention from an expert on the subject. ...
Transforming growth factor (TGF) is one of many characterized growth factors that exist in nature. ...
TGFα is upregulated in some human cancers. ...
Transforming Growth Factor beta (TGF beta) is a biological protein. ...
The Transforming growth factor (TGF) signaling pathway is involved in many cellular processes including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. ...
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