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BioMed Central | Full text | A mosaic genetic screen for novel mutations affecting Drosophilaneuroblast divisions (7713 words) |
 | The apical complex has several important functions during neuroblast asymmetric division including the correct orientation of the mitotic spindle along the apical-basal axis of the cell, the displacement of the spindle towards the basal cortex [6,7] and the establishment of a difference in spindle length between its apical and basal halves at anaphase [6,8]. |
| Although larval neuroblasts do not have a clear apical-basal polarity with respect to the overlying epithelium, such as that defined in embryonic neuroblasts, known apical components localize in a cortical crescent opposite a crescent of known basal components, with the metaphase plate aligned in between (Figure 1C). |
| In particular, we have identified a mutation affecting metaphase spindle orientation in neuroblasts, a process which is critical to the correct segregation of cell fate determinants, and another which appears to perturb the size asymmetry of the neuroblast division and the correct establishment of different identities in daughter cells. |
| Neuroblastoma: Encyclopedia of Medicine (1547 words) |
| Current research holds that neuroblastomas develop when cells produced by the fetus (neuroblast cells) fail to mature into normal nerve or adrenal cells and keep growing and proliferating. |
| The first symptom of a neuroblastoma is usually an unusual growth or lump, found in most cases in the abdomen of the child, causing discomfort or a sensation of fullness and pain. |
| Neuroblast cells—Cells produced by the fetus which mature into nerve cells and adrenal medulla cells. |
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