Neurodegenerative disease is a condition which affects the brain function. Neurodegenerative diseases result from deterioration of neurons. They are divided into two groups: A disease is any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. ... In the anatomy of animals, the brain, or encephalon, is the supervisory center of the nervous system. ... Neurons (also spelled neurones or called nerve cells) are the primary cells of the nervous system. ...
conditions causing problems with movements
conditions affecting memory and conditions related to dementia
Memory is a function of the brain: the ability to retain information. ... Dementia (from Latin demens) is progressive decline in cognitive function due to damage or disease in the brain beyond what might be expected from normal aging. ...
Motor disorders are another promising field for the therapeutic application of cannabinoid-related compounds, since the control of movement is one of the more relevant physiological roles of the endocannabinoid transmission in the brain.
Huntington's disease (HD) is an autosomal-dominant neurodegenerativedisorder caused by a CAG trinucleotide repeat expansion in the HD gene.
These disorders seem to have defective oxidative phosphorylation as a common pathway in their pathogenesis and it may be that treatments designed to improve respiratory chain function may ameliorate the progression of these disorders.
Neurodegenerative complications of the urinary tract are present in about two-thirds of those with this disorder, and at least 60% have neurological symptoms such as ataxia (unbalanced walking) and startle myoclonus (an increased reaction to strong stimuli such as loud noises).
Seizure disorders are not uncommon (20%; median age 19 years), and may be caused by hypoglycemia (low blood sugar) or by the underlying neurodegeneration.
Although the physiologic mechanism of this disorder is still under investigation, symptoms are currently believed to occur through defects in nuclear and mitochondrial DNA that code for cell processes controlled by mitochondria, a cellular component responsible for many cell functions.